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In Finland, AUD patients started rhythm control less frequently, and adjustment for comorbidities and socioeconomic status did not remove the association. The disparity persisted across therapy modalities, was intensified in lower-income groups, and supports targeted interventions for equitable 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was the study objective regarding alcohol use disorder and atrial fibrillation treatment?","Question",{"text":63,"@type":64},"To determine whether alcohol use disorder is associated with disparities in the initiation of rhythm control therapies in atrial fibrillation patients using a nationwide registry.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"How were rhythm control therapies defined in this research?",{"text":68,"@type":64},"Rhythm control initiation included antiarrhythmic drugs, cardioversion, and catheter ablation.",{"name":70,"@type":61,"acceptedAnswer":71},"What did the results show about rhythm control use in patients with alcohol use disorder?",{"text":72,"@type":64},"Patients with AUD initiated rhythm control therapies less often than those without AUD, and the lower use remained after adjustment for comorbidities and socioeconomic status.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},443618,1790742741,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,100,105,109,114,119,122,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":55,"doc_module":4,"doc_module_name":25,"category_name":97,"show_sort_weight":98,"slug":99},"Comic",60,"comic",{"id":101,"doc_module":4,"doc_module_name":25,"category_name":102,"show_sort_weight":103,"slug":104},6,"Technology",50,"technology",{"id":106,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":107,"slug":108},7,40,"healthcare",{"id":110,"doc_module":4,"doc_module_name":25,"category_name":111,"show_sort_weight":112,"slug":113},8,"Research & Report",30,"research-report",{"id":115,"doc_module":4,"doc_module_name":25,"category_name":116,"show_sort_weight":117,"slug":118},9,"Religion & 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Cup","world-cup",{"id":123,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":123,"slug":125},10,"Lifestyle","lifestyle",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":55,"slug":129},19,"General","general",{"code":4,"msg":82,"data":131},{"doc_id":79,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":106,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":106,"language":139,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":12,"update_tm":143,"read_time":144,"preview_page_count":4},2336474466412,"https://ap-avatar.wpscdn.com/davatar_155a257f0dc6eb9ab79c44ca47cae57d","IJC Heart & Vasculature 62 (2026) 101854  \nContents lists available at ScienceDirect  \nIJC Heart & Vasculature  \njournal [homepage:](homepage: www.sciencedirect.com/journal/ijc-heart-and-vasculature)[ www.sciencedirect.com/journal/ijc-heart-and-vasculature](homepage: www.sciencedirect.com/journal/ijc-heart-and-vasculature)  \n| Alcohol use disorder and use of rhythm control therapies in patients with atrial fibrillation: A nationwide cohort study |  |  | |\n| --- | --- | --- | --- |\n| Miika Vanhanena,*, Jussi Jaakkolab, Juhani K.E. Airaksinenc, Olli Halminend, Jukka Putaalae, Pirjo Mustonenf, Jari Haukkag, Juha Hartikainenh, Alex Luojusg, Mikko Niemig,\u003Cbr>Miika Linnad,i, Mika Lehtod,i,j, Konsta Teppoc,k\u003Cbr>a Faculty of Medicine, University of Turku, Turku, Finland\u003Cbr>b Cardiac Unit, Department of Internal Medicine, Satasairaala, Pori, Finland c Heart Centre, Turku University Hospital and University of Turku, Turku, Finland d Aalto University, Espoo, Finland\u003Cbr>e Department of Neurology, Helsinki University Hospital and University of Helsinki, Helsinki, Finland\u003Cbr>f Turku University Hospital and University of Turku, Finland g University of Helsinki, Helsinki, Finland\u003Cbr>h Kuopio University Hospital and University of Eastern Finland, Finland i University of Eastern Finland, Kuopio, Finland\u003Cbr>j Jorvi Hospital, Department of Internal Medicine, HUS Helsinki University Hospital and University of Helsinki, Helsinki, Finland k Biotechnology Unit, Department of Life Technologies, University of Turku, Turku, Finland |  |  |  |\n| A R T I C L E I N F O |  | A B S T R A C T |  |\n| Keywords:\u003Cbr>Atrial fibrillation Alcohol use disorder Rhythm control Antiarrhythmic therapy Socioeconomic Factors Registries |  | Objective: Patients with alcohol use disorder (AUD) often receive inferior treatment for somatic comorbidities. We aimed to examine whether AUD is associated with disparities in the use of antiarrhythmic therapies (AAT) for rhythm control in atrial fibrillation (AF) patients, using a nationwide registry.\u003Cbr>Methods: The Finnish AntiCoagulation in Atrial Fibrillation (FinACAF) registry includes all 229,565 patients with incident AF diagnosed in Finland between 2007 and 2018, identified from comprehensive national healthcare registries. The primary outcome was initiation of rhythm control therapies, including antiarrhythmic drugs, cardioversion, and catheter ablation, in patients with and without AUD.\u003Cbr>Results: The mean age was 72.7 years, 50 % were female and 4.7 % had AUD. Rhythm control was initiated less often in patients with AUD compared to those without (13.6 % vs. 21.8 %, p \u003C 0.001). After adjustment for comorbidities and socioeconomic status, AUD remained associated with lower use of rhythm control therapies (HR 0.65; 95 % CI 0.62–0.69). This disparity was consistent across all modalities of rhythm control (antiarrhythmic drugs, cardioversion and catheter ablation). While no significant interaction was observed with sex or age, income modified the association (p \u003C 0.001), with the lowest income tertile showing the greatest disparity (HR 0.37; 95 % CI 0.32–0.42).\u003Cbr>Conclusions: AUD is independently associated with markedly lower use of rhythm control therapies in AF patients. These disparities are most pronounced among socioeconomically disadvantaged individuals, highlighting the need for targeted interventions to ensure equitable treatment access. |  |\n\n1. Introduction  \nAtrial fibrillation (AF) is the most prevalent arrhythmia, affecting up to 5.2 % of the adult population in developed countries [1]. Recent global estimates further highlight its increasing public health burden, with both the prevalence and incidence of AF rising steadily over the  \npast three decades. In 2021, more than 4.4 million new AF or atrial flutter cases and over 8 million disability-adjusted life years were reported worldwide [2]. Elevated systolic blood pressure and increased body mass index remain the leading modifiable risk factors driving this gl","cbCaidG0D0lQucie","https://ap.wps.com/l/cbCaidG0D0lQucie","pdf",1904069,"English","# Introduction\n# Objective\n# Methods\n## Primary outcome\n# Results\n## Use of rhythm control therapies\n## Effect modification by income\n# Conclusions","[{\"question\":\"What was the study objective regarding alcohol use disorder and atrial fibrillation treatment?\",\"answer\":\"To determine whether alcohol use disorder is associated with disparities in the initiation of rhythm control therapies in atrial fibrillation patients using a nationwide registry.\"},{\"question\":\"How were rhythm control therapies defined in this research?\",\"answer\":\"Rhythm control initiation included antiarrhythmic drugs, cardioversion, and catheter ablation.\"},{\"question\":\"What did the results show about rhythm control use in patients with alcohol use disorder?\",\"answer\":\"Patients with AUD initiated rhythm control therapies less often than those without AUD, and the lower use remained after adjustment for comorbidities and socioeconomic status.\"}]","Alcohol use disorder and use of rhythm control therapies in patients with atrial fibrillation - A nationwide cohort study | PDF",1790704656,18]