[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-458190-105":59,"doc-detail-458190-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","albuminuria-as-a-non-invasive-biomarker-of-endothelial-dysfunction-in-patients-with-copd","Albuminuria as a non-invasive biomarker of endothelial dysfunction in patients with COPD","","Endothelial dysfunction contributes to chronic obstructive pulmonary disease (COPD), yet evidence linking urinary albumin measures to endothelial dysfunction and COPD outcomes remains limited. A cross-sectional study enrolled 60 adult COPD patients and 40 non-COPD smokers, assessing UACR alongside anthropometrics, SpO2, spirometry, 6-minute walk, flow-mediated dilation, laboratory tests, and comorbidities. COPD patients showed higher UACR, with albuminuria linked to higher BMI, more exacerbations, lower SpO2 and FMD, and higher fasting glucose. UACR correlated negatively with FMD and SpO2 and positively with comorbidities and fasting glucose, suggesting routine UACR for ED assessment, especially with low oxygen saturation.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/albuminuria-as-a-non-invasive-biomarker-of-endothelial-dysfunction-in-patients-with-copd/458190/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/albuminuria-as-a-non-invasive-biomarker-of-endothelial-dysfunction-in-patients-with-copd/458190.png","ImageObject",300,407,{"name":92,"@type":93},"Valentina","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-30","2026-09-30",true,{"@type":102,"interactionType":103,"userInteractionCount":39},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What was the aim of the study on COPD patients?","Question",{"text":112,"@type":113},"To assess albuminuria in adult COPD patients and examine how it relates to clinical and physiological parameters.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How were albuminuria-related measures evaluated?",{"text":117,"@type":113},"Urinary albumin-to-creatinine ratio (UACR) was measured, alongside assessments of SpO2, spirometry, the 6-minute walk test, and flow-mediated dilation (FMD) of the brachial artery.",{"name":119,"@type":110,"acceptedAnswer":120},"What main factors predicted albuminuria in COPD patients?",{"text":121,"@type":113},"High BMI, low SpO2, and high fasting plasma glucose were identified as main predictors, while the only independent predictor was low SpO2.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},458190,1791070195,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":39,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145,"preview_page_count":4},13056703020460,"https://ap-avatar.wpscdn.com/avatar/be000253dac470eee5d?_k=1778207105932848923","[www. nature.com/scientificreports](www. nature.com/scientificreports)  \nOPEN  \nAlbuminuria as a non-invasive biomarker of endothelial dysfunction in patients with COPD  \nMarwa Moaaz1􀀍, Sahar Mourad2, Ayman Baess2 & Rania Sweed2  \nEndothelial dysfunction (ED) plays a significant role in the pathogenesis of chronic obstructive pulmonary disease (COPD). While albuminuria is currently recognized as a biomarker of generalized ED, data on the evaluation of albuminuria among COPD patients and its association with disease outcome measures are still limited. Thus, the aim of this study was to assess albuminuria among a group of COPD patients and investigate its relationship with clinical and physiological parameters. Sixty adult patients with COPD and forty non-COPD adult smokers were included in this cross-sectional study. All participants were assessed for anthropometric parameters, oxygen saturation (SpO2), spirometry test, 6-minute walk test, flow-mediated dilation (FMD) of the brachial artery, routine laboratory measurements, and urinary albumin-to-creatinine ratio (UACR) . Patients with COPD had higher levels of UACR (mg/g) and a greater prevalence of albuminuriathan non-COPD smokers. COPD patients with albuminuria had higher body mass index (BMI), more frequent exacerbations, lower SpO2, lower FMD, and higher fasting plasma glucose than patients without albuminuria. UACR in COPD patients was associated negatively with FMD and SpO2 and positively with the number ofcomorbidities and fasting plasma glucose. The main predictors of albuminuria in COPD patients were high BMI, low SpO2, and high fasting plasma glucose. The only independent predictor of albuminuria was the presence of low  \nSpO2. Given the significant association with FMD, the gold standard measure of ED, we suggest that the measurement of UACR could be routinely utilized for assessing ED in COPD patients, particularly those with low oxygen saturation.  \nKeywords Chronic obstructive pulmonary disease, Albuminuria, Endothelial dysfunction, Hypoxemia.  \nChronic obstructive pulmonary disease (COPD) is a worldwide health problem and a leading cause of mortality. It represents a heterogeneous spectrum of lung pathologies primarily induced by prolonged inhalational exposures. The four key pathologic processes in COPD include small airway disease, mucus hypersecretion, emphysema, and pulmonary vascular dysfunction1.  \nThe pulmonary vascular dysfunction in COPD, especially in the vascular phenotype, is a component of the generalized vascular endothelial dysfunction (ED) that develops in response to inhaled insults. ED plays a significant role in the natural history of COPD and contributes to the pathogenesis of many comorbidities, including cardiovascular disease (CVD), the most prevalent comorbidity in COPD patients that results in the worst disease outcomes2. This indicates the need for early and regular evaluation of endothelial function in COPD patients to ensure early detection and rapid intervention.  \nAssessing endothelial function is complex, and while numerous techniques have advanced research in this area, none have been accepted as diagnostic tools in routine clinical practice. This may result from their invasive nature or their requirement for patient preparation and cooperation, which may be demanding for some patients3. In clinical settings, the ultrasound-based assessment of flow-mediated dilation (FMD) of the brachial artery has been regarded as the reference procedure for evaluating endothelial function. Nevertheless, its use in daily clinical practice can be challenging considering the need for precise standardization, adherence to strict protocols, experienced operators, and a controlled environment4. In addition, evidence exists that ED in COPD patients occurs not only in the macrovasculature, assessed by FMD, but also in the microvasculature. This suggests that other methods capable of evaluating the microvascular function should be employed to assess ED i","cbCaihaddXykfMHx","https://ap.wps.com/l/cbCaihaddXykfMHx","pdf",1711585,11,"English","# Materials and methods\n## Study subjects","[{\"question\":\"What was the aim of the study on COPD patients?\",\"answer\":\"To assess albuminuria in adult COPD patients and examine how it relates to clinical and physiological parameters.\"},{\"question\":\"How were albuminuria-related measures evaluated?\",\"answer\":\"Urinary albumin-to-creatinine ratio (UACR) was measured, alongside assessments of SpO2, spirometry, the 6-minute walk test, and flow-mediated dilation (FMD) of the brachial artery.\"},{\"question\":\"What main factors predicted albuminuria in COPD patients?\",\"answer\":\"High BMI, low SpO2, and high fasting plasma glucose were identified as main predictors, while the only independent predictor was low SpO2.\"}]","Albuminuria as a non-invasive biomarker of endothelial dysfunction in patients with COPD | PDF",1790752015,28]