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It traces the post–ChatGPT shift in language models, highlights DeepSeek R1’s transparent and chain-of-thought reasoning, and surveys major companies’ “Deep Research” products. A demonstration using Grok 3’s DeepSearch shows iterative web/database querying, stepwise paper retrieval, synthesis, and report generation for a biomedical query about missed appointments.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/ais-deep-research-revolution-transforming-biomedical-literature-analysis-editorial/433703/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/ais-deep-research-revolution-transforming-biomedical-literature-analysis-editorial/433703.png","ImageObject",300,407,{"name":92,"@type":93},"Eliana","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-08","2026-09-29",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",12,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What is the key development emphasized in the editorial?","Question",{"text":113,"@type":114},"The editorial highlights advancement in reasoning shown through iterative processes: clarifying intent, formulating queries, searching sources, reading and summarizing content, then producing comprehensive reports with follow-up questions.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"Why is DeepSeek R1 presented as distinctive?",{"text":118,"@type":114},"DeepSeek R1 is noted for “Explainable Reasoning” and structured problem solving using chain-of-thought reasoning, along with higher cost effectiveness.",{"name":120,"@type":111,"acceptedAnswer":121},"How does the editorial demonstrate the new capability?",{"text":122,"@type":114},"It describes using Grok 3’s DeepSearch with a query about “papers about missed appointments since 2023,” then narrates how the system searches, retrieves articles from biomedical databases, and compiles summarized results with links.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},433703,1790874140,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":14,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":24,"preview_page_count":4},4398048949847,"https://ap-avatar.wpscdn.com/avatar/400002536579ef2da7f?_k=1778318612642679267","J Chin MedAssoc  \nEditorial  \nAI’s deep research revolution: Transforming biomedical literature analysis  \nYing-Mei Wanga,b,c, Tzeng-Ji Chend,e,f,*  \naDepartment of Medical Education and Research, Taipei Veterans General Hospital Hsinchu Branch, Hsinchu, Taiwan, ROC; bDepartment of Pharmacy, Taipei Veterans General Hospital Hsinchu Branch, Hsinchu, Taiwan, ROC; cSchool of Medicine, National Tsing Hua University, Hsinchu, Taiwan, ROC; dDepartment of Family Medicine, Taipei Veterans General Hospital Hsinchu Branch, Hsinchu County, Taiwan, ROC; eDepartment of Family Medicine, Taipei Veterans General Hospital, Taipei, Taiwan, ROC; fDepartment of Post-Baccalaureate Medicine, National Chung Hsing University, Taichung, Taiwan, ROC  \nTwo years ago, shortly after the release of ChatGPT in late November 2022, the Journal of the Chinese Medical Association (JCMA) published an editorial, highlighting the impact of ChatGPT and other artificial intelligence (AI) applications on scientific writing.1 Meanwhile, large language model (LLM) AI has drastically changed the world. The emergence of open source DeepSeek R1 in late January 2025 further shook up the world of AI.2,3  \nThe most important feature of the latest development is the advancement of reasoning, which is displayed throughout the iterative processes of thinking about the user’s intent, formulating the query, searching the Web or a specific database, reading and summarizing the content, and then responding with a comprehensive report and suggesting follow-up questions. Reasoning is not a unique feature of DeepSeek R1 and has been built into LLMs since their inception. However, a further refinement of the reasoning capability as a specialized AI agent appeared recently. DeepSeek R1 stands out for its transparency (“Explainable Reasoning”to articulate its reasoning process as it arrives at conclusions) and structured problem solving (“Chainof-Thought Reasoning” to break down complex problems into structured steps), in addition to higher cost effectiveness.4,5  \nThe major AI companies have responded quickly by either lowering the prices of existing products or launching similar products, such as Google’s Gemini Deep Research (launched on December 11, 2024),6 OpenAI’s Deep Research (February 4, 2025),7 Perplexity AI’s Deep Research (February 14, 2025),8 and Grok 3’s DeepSearch (February 20, 2025) .9 Currently, some of these products are free to try, so that researchers in academia can take advantage of the opportunity to test this new AI capability.  \nFor demonstration purposes, we have tried Grok 3’s DeepSearch with a simple query without any hint: “papers about missed appointments since 2023.”With this query, we wanted to find recent publications on the topic about which a paper had been published in the JCMA 6 years earlier.10  \n*Address correspondence. Dr. Tzeng-Ji Chen, Department of Family Medicine, Taipei Veterans General Hospital Hsinchu Branch, 81, Section 1, Zhongfeng Road, Zhudong, Hsinchu 310, Taiwan, ROC. E-mail address: [tjchen@vhct.gov.tw](tjchen@vhct.gov.tw)[ ](tjchen@vhct.gov.tw)(T.-J. Chen).  \nConflicts of interest: Dr. Tzeng-Ji Chen, an editorial board member at Journal of the Chinese Medical Association, had no role in the peer review process of or decision to publish this article. The authors declare that they have no conflicts of interest related to the subject matter or materials discussed in this article.  \nJournal of Chinese Medical Association. (2025) 88: 415-416.  \nReceived March 18, 2025; accepted March 19, 2025. doi: 10. 1097/JCMA.0000000000001231  \nCopyright © 2025, the Chinese Medical Association. This is an open access article under the CC BY-NC-ND license ([http://creativecommons.org/licenses/](http://creativecommons.org/licenses/)[ ](http://creativecommons.org/licenses/)[by-nc-nd/4.0/](by-nc-nd/4.0/))  \nInitially, Grok 3 displayed a reasoning framework with a structured eight-step process: thinking, clarifying the request, analyzing the search results,","cbCaiqzJXdiY49eW","https://ap.wps.com/l/cbCaiqzJXdiY49eW","pdf",412283,"English","# AI’s deep research revolution: Transforming biomedical literature analysis\n## From ChatGPT to advanced reasoning models\n## Transparency and chain-of-thought reasoning\n## Industry responses with “Deep Research” products\n## Demonstration with Grok 3 DeepSearch\n## Iterative search, selection, and synthesis workflow","[{\"question\":\"What is the key development emphasized in the editorial?\",\"answer\":\"The editorial highlights advancement in reasoning shown through iterative processes: clarifying intent, formulating queries, searching sources, reading and summarizing content, then producing comprehensive reports with follow-up questions.\"},{\"question\":\"Why is DeepSeek R1 presented as distinctive?\",\"answer\":\"DeepSeek R1 is noted for “Explainable Reasoning” and structured problem solving using chain-of-thought reasoning, along with higher cost effectiveness.\"},{\"question\":\"How does the editorial demonstrate the new capability?\",\"answer\":\"It describes using Grok 3’s DeepSearch with a query about “papers about missed appointments since 2023,” then narrates how the system searches, retrieves articles from biomedical databases, and compiles summarized results with links.\"}]","AI’s deep research revolution - Transforming biomedical literature analysis - Editorial | PDF",1790665180]