[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-331741-105":59,"doc-detail-331741-en":131},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":124,"head_meta":126,"extra_data":128,"updated_unix":130},105,"en","agent-orange-and-head-and-neck-cancer-a-systematic-review-and-meta-analysis","Agent Orange and head and neck cancer: A systematic review and meta-analysis","","Objective: assess the incidence of head and neck cancer in patients exposed to Agent Orange and related dioxins. Methods: studies were identified via CINAHL, PubMed, and Scopus (through April 2023) and included reports of incidence and/or deaths from head and neck cancer in exposed participants. Meta-analysis of proportions estimated incidence and mortality by primary site, with comparisons between exposed and control groups using differences in proportions. Results: 13 studies were included; oral cavity and larynx were common, and exposed patients showed higher overall incidence than unexposed controls, with increased risk of death. Conclusions: findings suggest increased head and neck cancer occurrence and mortality after exposure, warranting further subsite-specific evaluation.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/agent-orange-and-head-and-neck-cancer-a-systematic-review-and-meta-analysis/331741/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/agent-orange-and-head-and-neck-cancer-a-systematic-review-and-meta-analysis/331741.png","ImageObject",300,407,{"name":92,"@type":93},"Ophelia","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-27","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",11,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What was the objective of the systematic review and meta-analysis?","Question",{"text":113,"@type":114},"To assess the incidence of head and neck cancer in patients exposed to Agent Orange and related dioxins, including incidence and deaths due to head and neck cancer.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"Which databases were used to identify studies, and what was the cutoff date?",{"text":118,"@type":114},"Studies were identified through CINAHL, PubMed, and Scopus, with primary study identification through April 2023.",{"name":120,"@type":111,"acceptedAnswer":121},"What were the main findings regarding cancer incidence and mortality?",{"text":122,"@type":114},"Exposed patients had a higher incidence of head and neck cancer than unexposed controls, and individuals exposed to Agent Orange were more likely to die from head and neck cancer. The most common subsite among exposed patients with reported subsites included oral cavity and larynx.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},331741,1790787766,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":44,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145,"preview_page_count":4},7971461741311,"https://ap-avatar.wpscdn.com/avatar/74000253aff267980c6?x-image-process=image/resize,m_fixed,w_180,h_180&k=1779345379180704826","DOI: 10.1002/wjo2.198  \nREV I EW ART I CLE  \nAgent Orange and head and neck cancer: A systematic review and meta‐analysis  \nNeil P. Monaghan1,2  | Kelsey A. Duckett1,2 | Shaun A. Nguyen1 | Jason G. Newman1 | Alexandra E. Kejner1 | W. Greer Albergotti1  \n1Department of Otolaryngology—Head and Neck Surgery, Medical University of South Carolina, Charleston, South Carolina, USA 2College of Medicine, Medical University of South Carolina, Charleston, South Carolina, USA  \nCorrespondence  \nShaun A. Nguyen, Department of Otolaryngology—Head and Neck Surgery, Medical University of South Carolina, 135 Rutledge Ave., MSC 550, Charleston, SC 29425, USA.  \nEmail: [nguyensh@musc.edu](nguyensh@musc.edu)  \nFunding information None  \nAbstract  \nObjective: To assess the incidence of head and neck cancer in patients exposed to Agent Orange and related dioxins.  \nMethods: Studies were identified through CINAHL, PubMed, and Scopus. Primary studies were identified through April 2023 . Articles were included reporting incidence of head and neck cancer and/or deaths due to head and neck cancer in participants exposed to Agent Orange. Meta‐analysis of proportions was conducted to calculate incidence and mortality by primary site in those who were exposed to Agent Orange and for control groups. A comparison of proportions was used to compare rates in exposed and control groups.  \nResults: Of 1530 unique abstracts screened, 13 studies were included in the systematic review. Of the exposed patients with reported subsites, oral cavity (31 .2%), and larynx (14%) were the most common. Of the exposed patients with reported deaths and subsites, oropharynx (0.25%) was the most common primary site in patients who died. The most common subsites of those who were not exposed, oropharynx (0 . 13%), and larynx (0 . 16%) . Head and neck cancer of all subsites was more common in those exposed to Agent Orange than in unexposed controls (difference 0 .061%; 95% confidence interval: 0 .04%–0 .08%, p \u003C 0 .0001) . Conclusions: Our findings suggest that head and neck cancer is more common in those who were exposed to Agent Orange than those who were not. Additionally, individuals exposed to Agent Orange were more likely to die from head and neck cancer. Further investigation is warranted to evaluate subsite‐specific outcomes given the limitations of our study design.  \nKEYWO R DS  \nAgent Orange, head and neck cancer, Vietnam Conflict, Vietnam War  \nThis is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.  \n© 2024 The Author(s) . World Journal of Otorhinolaryngology ‐ Head and Neck Surgery published by John Wiley & Sons Ltd on behalf of Chinese Medical Association.  \n[138](138 | wileyonlinelibrary.com/journal/wjo2)[ |](138 | wileyonlinelibrary.com/journal/wjo2)[ wileyonlinelibrary.com/journal/wjo2](138 | wileyonlinelibrary.com/journal/wjo2) World J Otorhinolaryngol Head Neck Surg. 2025;11:138–146.  \nINTRODUCTION  \nThe Vietnam War spanned two decades and resulted in millions of Americans being stationed in southeast Asia. According to the United States Department of Veterans Affairs (VA), over 6,000,000 of those veterans are still living and now reside in the United States. Herbicides were widely used in Vietnam to eliminate underbrush and destroy crops used by theVietnamese forces.1 Agent Orange, the most frequently used herbicide in the Vietnam War,2,3 has been a hot topic of medical investigation for more than 45 years.4–7 Agent Orange contains a mixture of chemicals, but in Vietnam, it was highly contaminated with 2,3,7,8‐tetrachlorodibenzo‐p‐dioxin (TCDD), the most dangerous dioxin to humans.2  \nWhile the mechanism is not well understood, Agent Orange has been linked to several cancers, including genitourinary cancers, thyroid cancer, and multiple ","cbCaiu57TaxJYYnj","https://ap.wps.com/l/cbCaiu57TaxJYYnj","pdf",727032,"English","# Introduction\n# Methods\n# Results\n# Conclusions","[{\"question\":\"What was the objective of the systematic review and meta-analysis?\",\"answer\":\"To assess the incidence of head and neck cancer in patients exposed to Agent Orange and related dioxins, including incidence and deaths due to head and neck cancer.\"},{\"question\":\"Which databases were used to identify studies, and what was the cutoff date?\",\"answer\":\"Studies were identified through CINAHL, PubMed, and Scopus, with primary study identification through April 2023.\"},{\"question\":\"What were the main findings regarding cancer incidence and mortality?\",\"answer\":\"Exposed patients had a higher incidence of head and neck cancer than unexposed controls, and individuals exposed to Agent Orange were more likely to die from head and neck cancer. The most common subsite among exposed patients with reported subsites included oral cavity and larynx.\"}]","Agent Orange and head and neck cancer: A systematic review and meta-analysis | PDF",1789994955,23]