[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-428017-105":59,"doc-detail-428017-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","age-related-acute-subjective-behavioral-cognitive-and-cardiovascular-effects-of-tetrahydrocannabinol","Age-Related Acute Subjective, Behavioral, Cognitive and Cardiovascular Effects of Tetrahydrocannabinol","","Recreational and medical cannabis use in older adults is rising alongside legalization, yet the acute effects of cannabinoids in this population remain insufficiently studied. Older individuals may be more vulnerable to THC due to age-related changes in the endocannabinoid system, cognition, psychomotor function, postural stability, cardiovascular reserve, and drug metabolism. A controlled double-blind, placebo-controlled crossover study will present subjective, behavioral, cognitive, psychomotor, and cardiovascular responses, and examine THC pharmacokinetics across age groups.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/age-related-acute-subjective-behavioral-cognitive-and-cardiovascular-effects-of-tetrahydrocannabinol/428017/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/age-related-acute-subjective-behavioral-cognitive-and-cardiovascular-effects-of-tetrahydrocannabinol/428017.png","ImageObject",300,407,{"name":92,"@type":93},"Aditya","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-08","2026-09-29",true,{"@type":102,"interactionType":103,"userInteractionCount":34},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"Why is the study focused on older adults and THC acute effects?","Question",{"text":112,"@type":113},"Cannabis use is increasing in older adults, and there are higher odds of cannabis-related problems in those aged 55 and above. Despite many studies in younger populations, acute cannabinoid effects in older adults are not well-studied.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What mechanisms may make older adults more vulnerable to THC?",{"text":117,"@type":113},"Age-related changes may affect the endocannabinoid system (THC’s target), cognitive function, psychomotor function, postural stability, cardiovascular reserve, and drug metabolism, increasing vulnerability.",{"name":119,"@type":110,"acceptedAnswer":120},"What preliminary results are reported regarding memory and anxiety in older adults?",{"text":121,"@type":113},"Under THC relative to placebo, older individuals recalled fewer words than younger controls on both immediate and delayed recall, and they reported greater THC-induced anxiogenic (anxiety-producing) effects.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},428017,1790766988,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":34,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":8,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":81},962085564549,"https://ap-avatar.wpscdn.com/davatar_085a072bc5b1113ac321206ff7593b45","Innovation in Aging, 2025, Vol. 9, No. S2 575  \nAbstract citation ID: igaf122.1970  \nAGE-RELATED ACUTE SUBJECTIVE, BEHAVIORAL,  \nCOGNITIVE AND CARDIOVASCULAR EFFECTS OF  \nTETRAHYDROCANNABINOL  \nDeepak Cyril D’Souza, Yale University, New Haven, Connecticut, United States  \nThere has been a relatively recent increase in recreational and medical cannabis use in older adults compared to younger adults which is projected to further increase4 and is associated with legalization of cannabis. Further, there are higher odds of cannabis-related problems in those ≥55 years including a significant increase in emergency department visits for acute consequences of cannabis. However, although there is a wealth of studies of cannabis effects in younger populations, the acute effects of cannabinoids in older adults have not been well-studied.  \nLittle is known about their effects in older individuals despite growing use of cannabis in this demographic. Age-related changes in 1) the endocannabinoid system, the target of THC, 2) cognitive function, 3) psychomotor function, 4) postural stability, 5) cardiovascular reserve, and 6) drug metabolism may render older adults more vulnerable to THC and cannabis. Data from a controlled double-blind, placebo-controlled crossover study on the subjective, behavioral, cognitive, psychomotor and cardiovascular effects of THC in older vs. younger adults will be presented.  \nAge-related differences in the pharmacokinetics ofTHC will also be explored. On immediate recall, older individuals recalled fewer words vs. younger controls under the influence of THC relative to placebo both on immediate and delayed recall.  \nFurthermore, relative to younger individuals, older individuals reported greater THC-induced anxiogenic effects. These preliminary data support further research on the benefits and risks of cannabis an its principal active constituent THC, in the aging population.","cbCaihQQRzFShjzo","https://ap.wps.com/l/cbCaihQQRzFShjzo","pdf",533101,"English","# Abstract\n## Study focus and rationale\n## Expected age-related vulnerabilities\n## Study design and measured outcomes\n## Preliminary findings and implications","[{\"question\":\"Why is the study focused on older adults and THC acute effects?\",\"answer\":\"Cannabis use is increasing in older adults, and there are higher odds of cannabis-related problems in those aged 55 and above. Despite many studies in younger populations, acute cannabinoid effects in older adults are not well-studied.\"},{\"question\":\"What mechanisms may make older adults more vulnerable to THC?\",\"answer\":\"Age-related changes may affect the endocannabinoid system (THC’s target), cognitive function, psychomotor function, postural stability, cardiovascular reserve, and drug metabolism, increasing vulnerability.\"},{\"question\":\"What preliminary results are reported regarding memory and anxiety in older adults?\",\"answer\":\"Under THC relative to placebo, older individuals recalled fewer words than younger controls on both immediate and delayed recall, and they reported greater THC-induced anxiogenic (anxiety-producing) effects.\"}]","Age-Related Acute Subjective, Behavioral, Cognitive and Cardiovascular Effects of Tetrahydrocannabinol | PDF",1790645533]