[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-452666-105":59,"doc-detail-452666-en":131},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":124,"head_meta":126,"extra_data":128,"updated_unix":130},105,"en","age-matters-unraveling-the-link-between-early-onset-hypertension-and-ckd-editorial","Age Matters - Unraveling the Link between Early-Onset Hypertension and CKD - Editorial","","Age of onset of hypertension is presented as a major public health concern with clear relevance to subsequent chronic kidney disease (CKD) risk. The text summarizes global burden estimates, evidence from population cohorts showing a graded increase in CKD and end-stage kidney disease when hypertension begins at younger ages, and attenuation with older onset. It also highlights longitudinal blood pressure trajectories from youth and provides editorial context for a UK Biobank analysis evaluating risk, supporting methods, and implications for early detection, lifestyle intervention, renal monitoring, and integrated hypertension–cardiovascular care.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/age-matters-unraveling-the-link-between-early-onset-hypertension-and-ckd-editorial/452666/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/age-matters-unraveling-the-link-between-early-onset-hypertension-and-ckd-editorial/452666.png","ImageObject",300,407,{"name":92,"@type":93},"hdkawk","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-30","2026-09-30",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",13,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"Why is the age of hypertension onset considered important for CKD risk?","Question",{"text":113,"@type":114},"The article explains that earlier onset is linked to higher subsequent CKD risk, including subclinical renal damage and progression to ESKD, making timing a critical factor for nephrology research and prevention.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"What does the evidence show about how CKD risk changes with age at hypertension diagnosis?",{"text":118,"@type":114},"Cohort data indicate a graded association: CKD, renal decline, and ESKD risks are highest when hypertension develops at younger ages and decline as onset age increases.",{"name":120,"@type":111,"acceptedAnswer":121},"What are the practical implications suggested for younger hypertensive populations?",{"text":122,"@type":114},"The text calls for targeted interventions such as early detection, lifestyle modification, and regular renal function monitoring, and it emphasizes integrated care addressing both hypertension and cardiovascular disease.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},452666,1790888984,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":14,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":24,"preview_page_count":4},3985747859855,"https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c","Editorial  \nAge Matters  \nUnraveling the Link between Early-Onset Hypertension and CKD  \nRodrigo O. Marao´n   \nKidney360 6: 1643–1644, 2025. doi: [https://doi.org/10.34067/KID.0000000928](https://doi.org/10.34067/KID.0000000928)  \nThe association between the age of onset of hypertension and the subsequent risk of CKD is both a pressing public health issue and a critical area of study in nephrology. According the World Health Organization, hypertension affects over 1.28 billion people worldwide, contributing significantly to the burden of cardiovascular diseases (CVDs) and CKDs.1 Epidemiologic studies have shown that CKD affects approximately 700 million individuals globally, accounting for roughly 9.4% of the population, and is responsible for 1.4 million annual deaths. Particularly, chronic hypertension is recognized as a principal risk factor for CKD, with estimates suggesting that up to 90% of CKD patients have a history of hypertension.2 This highlights the urgency of understanding how factors such as the timing of hypertension onset can influence the likelihood of developing CKD.  \nThe growing evidence demonstrates that earlier onset of hypertension is associated with a higher subsequent risk of CKD, including subclinical renal damage, proteinuria, and progression to ESKD. Large population-based cohort studies from diverse populations have shown that the relative risk of CKD, renal decline, and ESKD is highest when hypertension develops at a younger age, with the risk attenuating as the age of hypertension onset increases. For example, in a UK cohort, individuals with hypertension onset at 18–39 years had a hazard ratio (HR) for CKD of 3.69 (95% confidence interval, 3.53 to 3.86), compared with an HR of 2.01 (1.96 to 2.06) for those with onset at 80 years or older; the pattern was similar for ESKD, with HRs of 17.26 (14.34 to 20.77) for the youngest group versus 2.55 (2.12 to 3.07) for the oldest.3 This graded association is corroborated in Asian populationsand in patients with diabetes, where the effect of elevated BP on ESKD risk is most pronounced in those younger  \nthan 40 years, and diminishes with advancing age at hypertension onset.4,5  \nLongitudinal studies tracking BP trajectories from childhood into adulthood further support that persistently elevated or increasing BP from a young age is associated with higher urinary albumin-to-creatinine ratios and greater odds of subclinical renal disease in middle age, independent of other risk factors.6 Early-onset hypertension is also associated with albuminuria and other forms of hypertension-mediated organ damage by midlife, whereas hypertension onset at age 45 years or older isnot consistently linked to increased risk of renal endorgan damage.7,8  \nCross-sectional and longitudinal analyses confirm that the association between hypertension and CKD is strongest at younger ages, with prevalence ratios for stage 3 or 4 CKD and albuminuria associated with hypertension being highest in adults aged 20–49, and progressively lower in older age groups.5 New-onset hypertension, even over short follow-up periods, increases the risk of developing proteinuria, a key marker of CKD, particularly in men and in those with high-normal BP.9 In this issue of Kidney360, Lu et al.10 provide critical insights into this association, leveraging robust data from the UK Biobank. This study, encompassing 485,101 participants, reveals a compelling trend: the younger the age at hypertension onset, the higher the risk of developing CKD. Specifically, individuals diagnosed with hypertension younger than 45 years exhibited the highest HRs for CKD, underscoring the vulnerability of this subgroup. The findings are further strengthened using propensity score matching and Cox proportional hazards models, which ensure methodologic rigor and minimize confounding biases.  \nDepartment of Physiology, Area Morphophysiology, Faculty of Medicine, National University of Tucum´an, INSIBIO-CONICET, San Miguel de Tucum´an, A","cbCaisDZKhtMi0u4","https://ap.wps.com/l/cbCaisDZKhtMi0u4","pdf",152921,"English","# Editorial\n## Public health burden\n## Evidence for age-dependent CKD risk\n## Findings from cohort and longitudinal studies\n## Methods and insights from the UK Biobank study\n## Clinical and research implications","[{\"question\":\"Why is the age of hypertension onset considered important for CKD risk?\",\"answer\":\"The article explains that earlier onset is linked to higher subsequent CKD risk, including subclinical renal damage and progression to ESKD, making timing a critical factor for nephrology research and prevention.\"},{\"question\":\"What does the evidence show about how CKD risk changes with age at hypertension diagnosis?\",\"answer\":\"Cohort data indicate a graded association: CKD, renal decline, and ESKD risks are highest when hypertension develops at younger ages and decline as onset age increases.\"},{\"question\":\"What are the practical implications suggested for younger hypertensive populations?\",\"answer\":\"The text calls for targeted interventions such as early detection, lifestyle modification, and regular renal function monitoring, and it emphasizes integrated care addressing both hypertension and cardiovascular disease.\"}]","Age Matters - Unraveling the Link between Early-Onset Hypertension and CKD - Editorial | PDF",1790737546]