[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-426266-105":59,"doc-detail-426266-en":134},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":127,"head_meta":129,"extra_data":131,"updated_unix":133},105,"en","age-and-sex-differences-in-dehydroepiandrosterone-sulfate-among-people-with-dementia-and-caregivers","AGE AND SEX DIFFERENCES IN DEHYDROEPIANDROSTERONE SULFATE AMONG PEOPLE WITH DEMENTIA AND CAREGIVERS","","Dehydroepiandrosterone sulfate (DHEAS), a key adrenal hormone with neuroprotective and anti-glucocorticoid properties, is examined for its role in dementia and caregiving. The study compared basal DHEAS levels and awakening responses between people with dementia (PWD) and family caregivers, focusing on age- and sex-specific patterns. Salivary samples were collected at awakening and 30 minutes later. Results revealed sex- and age-stratified differences: higher basal DHEAS in older females with dementia, a male crossover pattern around age 75, and the largest awakening-response differences in younger males.",{"@graph":69,"@context":126},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/age-and-sex-differences-in-dehydroepiandrosterone-sulfate-among-people-with-dementia-and-caregivers/426266/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/age-and-sex-differences-in-dehydroepiandrosterone-sulfate-among-people-with-dementia-and-caregivers/426266.png","ImageObject",300,407,{"name":92,"@type":93},"Dipper","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-22","2026-09-29",true,{"@type":102,"interactionType":103,"userInteractionCount":29},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118,122],{"name":109,"@type":110,"acceptedAnswer":111},"What was the study trying to understand about DHEAS in dementia?","Question",{"text":112,"@type":113},"The study assessed whether salivary DHEAS levels and awakening responses differ between people with dementia and their family caregivers, considering age- and sex-specific patterns.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How were DHEAS measurements collected and analyzed?",{"text":117,"@type":113},"Salivary samples were collected at awakening and 30 minutes post-awakening, followed by independent group comparisons and sex- and age-stratified analyses (\u003C65, 65–75, >75), plus interaction modeling.",{"name":119,"@type":110,"acceptedAnswer":120},"What were the main findings regarding sex and age differences?",{"text":121,"@type":113},"Among females, PWD showed higher basal DHEAS than caregivers after age 65; among males, a crossover pattern emerged around age 75. Awakening-response differences were most pronounced in younger males, with lower responses in PWD versus caregivers.",{"name":123,"@type":110,"acceptedAnswer":124},"Why might DHEAS be important for dementia care?",{"text":125,"@type":113},"The findings suggest DHEAS profiles differ between PWD and caregivers and may function as a noninvasive biomarker of neuroendocrine function, informing stress regulation and potential intervention targets.","https://schema.org",{"og:url":83,"og:type":128,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":130,"canonical":83},"index,follow",{"doc_id":132,"site_id":62},426266,1790790812,{"code":4,"msg":5,"data":135},{"doc_id":132,"user_id":136,"nickname":92,"user_avatar":137,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":138,"file_id":139,"file_url":140,"file_type":141,"file_size":142,"view_count":29,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":8,"language":143,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":144,"faqs":145,"seo_title":146,"seo_description":67,"update_tm":147,"read_time":81},1374404997633,"https://ap-avatar.wpscdn.com/davatar_a8503ba1806abce46bf441b54a3ca4cd","1214 Innovation in Aging, 2025, Vol. 9, No. S2  \nAbstract citation ID: igaf122.4063  \nAGE AND SEX DIFFERENCES INDEHYDROEPIANDROSTERONE SULFATE AMONG PEOPLE WITH DEMENTIA AND CAREGIVERS  \nWanrui Wei1, Töres Theorell2, Gabriella Engstrom3, and Azita Emami1, 1. Yale University, Orange, Connecticut, United States, 2. Karolinska Institutet, Stockholm, Stockholms Lan, Sweden, 3. Florida Atlantic University, Boca Raton, Florida, United States  \nDehydroepiandrosterone sulfate (DHEAS) is a key adrenal hormone with neuroprotective and anti-glucocorticoid properties, yet little is known about its role in dementia and caregiving contexts. This study compared basal DHEAS levels and awakening responses between people with dementia (PWD) and their family caregivers, while examining age-and sex-specific patterns. Salivary samples were collected at awakening and 30 minutes post-awakening. Analyses included independent group comparisons, sex-and age-stratified analyses (\u003C 65, 65–75, >75 years), and interaction modeling. Results showed that among females, PWD exhibited significantly higher basal DHEAS than caregivers after age 65, while in males, a crossover pattern emerged: PWD demonstrated higher levels before age 75, whereas caregivers showed slightly higher levels thereafter. Awakening response differences were most pronounced in younger males, with PWD displaying markedly lower responses relative to caregivers. These findings highlight distinct age- and sex-specific trajectories of DHEAS regulation in dementia. In conclusion, salivary DHEAS profiles differ between PWD and caregivers, with sex- and age-related variations. DHEAS may serve as a noninvasive biomarker of neuroendocrine function, providing insights into stress regulation and potential intervention targets for dementia care.","cbCairvMxTTQSZw9","https://ap.wps.com/l/cbCairvMxTTQSZw9","pdf",1065997,"English","# Abstract\n## DHEAS role in dementia and caregiving\n## Study design and sampling\n## Age- and sex-stratified results\n## Awakening response findings\n## Conclusion and implications","[{\"question\":\"What was the study trying to understand about DHEAS in dementia?\",\"answer\":\"The study assessed whether salivary DHEAS levels and awakening responses differ between people with dementia and their family caregivers, considering age- and sex-specific patterns.\"},{\"question\":\"How were DHEAS measurements collected and analyzed?\",\"answer\":\"Salivary samples were collected at awakening and 30 minutes post-awakening, followed by independent group comparisons and sex- and age-stratified analyses (\\u003c65, 65–75, \\u003e75), plus interaction modeling.\"},{\"question\":\"What were the main findings regarding sex and age differences?\",\"answer\":\"Among females, PWD showed higher basal DHEAS than caregivers after age 65; among males, a crossover pattern emerged around age 75. Awakening-response differences were most pronounced in younger males, with lower responses in PWD versus caregivers.\"},{\"question\":\"Why might DHEAS be important for dementia care?\",\"answer\":\"The findings suggest DHEAS profiles differ between PWD and caregivers and may function as a noninvasive biomarker of neuroendocrine function, informing stress regulation and potential intervention targets.\"}]","AGE AND SEX DIFFERENCES IN DEHYDROEPIANDROSTERONE SULFATE AMONG PEOPLE WITH DEMENTIA AND CAREGIVERS | PDF",1790640020]