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The medRxiv preprint details study authorship across multiple academic medical centers, funding from NHLBI/NIH and related NIH institutes, and formal disclosures regarding consulting fees, royalties, equity, speaker fees, and research support. The work is explicitly not peer reviewed and is not intended to guide clinical practice.",{"@graph":69,"@context":126},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/age-and-sex-adjusted-myocardial-flow-reserve-percentiles-for-personalized-cardiovascular-risk-assessment/442876/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/age-and-sex-adjusted-myocardial-flow-reserve-percentiles-for-personalized-cardiovascular-risk-assessment/442876.png","ImageObject",300,407,{"name":92,"@type":93},"hdkawk","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-06","2026-09-29",true,{"@type":102,"interactionType":103,"userInteractionCount":44},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118,122],{"name":109,"@type":110,"acceptedAnswer":111},"What is the study’s main focus?","Question",{"text":112,"@type":113},"The preprint focuses on age-and sex–adjusted myocardial flow reserve percentiles intended for personalized cardiovascular risk assessment.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Is this medRxiv preprint peer reviewed?",{"text":117,"@type":113},"No. The document states it reports new research not certified by peer review and should not be used to guide clinical practice.",{"name":119,"@type":110,"acceptedAnswer":120},"What funding sources support the research?",{"text":121,"@type":113},"Funding is reported from NHLBI/NIH (grant R35HL161195), NIBIB/NIH (grant R01EB034586), and additional NIH support (grant T32 HL094301).",{"name":123,"@type":110,"acceptedAnswer":124},"What types of disclosures are included?",{"text":125,"@type":113},"Disclosures include consulting fees, software royalties, equity, speaker fees, and research grant support from multiple named organizations and institutions.","https://schema.org",{"og:url":83,"og:type":128,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":130,"canonical":83},"index,follow",{"doc_id":132,"site_id":62},442876,1791074573,{"code":4,"msg":5,"data":135},{"doc_id":132,"user_id":136,"nickname":92,"user_avatar":137,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":138,"file_id":139,"file_url":140,"file_type":141,"file_size":142,"view_count":44,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":143,"language":144,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":145,"faqs":146,"seo_title":147,"seo_description":67,"update_tm":148,"read_time":149,"preview_page_count":4},3985747859855,"https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c","medRxiv preprint doi: [https://doi.org/10.64898/2025.12.30.25343223](https://doi.org/10.64898/2025.12.30.25343223); this version posted December 31, 2025. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity.  \nIt is made available under a CC-BY-NC-ND 4.0 International license .  \nAge-and Sex-Adjusted Myocardial Flow Reserve Percentiles for Personalized  \nCardiovascular Risk Assessment  \nLee Joseph 1, 2, Ludovic Trinquart3, 4, Diana M. Lopez 1, 5, Simone Brandao 1, Jenifer M. Brown 1, 5, Sanjay Divakaran 1, 5, Daniel Huck 1, 5, Brittany Weber6, Leanne Barrett Goldstein 1, Jon Hainer 1, Sylvain Carre 1, Mark Lemley7, Giselle Ramirez7, Joanna X. Liang7, Ron Blankstein 1, 5, Sharmila Dorbala1, 5, Erick Alexanderson8, Isabel Carvajal-Juarez8, Wanda Acampa9, Rene R. S.  \nPackard 10,11, Viet T. Le 12, Steve Mason 12, Stacey Knight 12, Panithaya Chareonthaitawee 13,  \nSamuel Wopperer 13, Thomas L. Rosamond 14, Ronny R. Buechel 15, Andrew J. Einstein 16, Mouaz  \nH. Al-Mallah 17, Leandro Slipczuk18, Mark I. Travin 18, Daniel S. Berman7, Damini Dey7, Piotr J.  \nSlomka \\#7, Marcelo F. Di Carli \\#1, 5.  \nAffiliations:  \n1Cardiovascular Imaging Program, Brigham and Women's Hospital, Boston, MA 02115 , USA  \n2Harvard T.H. Chan School of Public Health, Boston, MA 02115, USA  \n3Tufts Clinical and Translational Science Institute, Tufts University, Boston, MA 02111, USA.  \n4 Institute for Clinical Research and Health Policy Studies, Tufts Medical Center, Boston, MA 02111, USA  \n5Harvard Medical School, Boston, MA, 02115 , USA  \n6UT Southwestern Medical Center, Dallas, TX 75390 , USA  \n7Cedars-Sinai Medical Center, Los Angeles, CA, 90048 , USA  \n8National Institute of Cardiology “Ignacio Chavez”, Mexico City, Mexico  \n9Federico II University Hospital, Napoli, Italy  \n10David Geffen School of Medicine, University of California, Los Angeles, CA 90095, USA  \n11West Los Angeles Veterans Affairs Medical Center, Los Angeles, CA, 90073, USA  \n12Intermountain Medical Center, Murray, UT 84107 , USA  \n13Mayo Clinic, Rochester, MN, 55905 , USA  \n14The University of Kansas Health System, Kansas City, KS, 66160, USA  \n15University Hospital Zurich, Zurich, Switzerland  \n16Columbia University/New York-Presbyterian Hospital, New York, 10032, USA  \n17Houston Methodist Academic Institute, Houston, TX, 77030, USA  \n18 Montefiore Health System/Albert Einstein College of Medicine, Bronx, NY, 10461, USA  \n\\#Contributed equally.  \nCorrespondence to: Marcelo F. Di Carli, MD | Brigham and Women’s Hospital, 75 Francis St, ASB-L1 037-C, Boston, [MA 02115 | e-mail:](MA 02115 | e-mail: mdicarli@bwh.harvard.edu | Tel:)[ ](MA 02115 | e-mail: mdicarli@bwh.harvard.edu | Tel:)[mdicarli@bwh.harvard.edu](MA 02115 | e-mail: mdicarli@bwh.harvard.edu | Tel:)[ | Tel:](MA 02115 | e-mail: mdicarli@bwh.harvard.edu | Tel:) 617-732-6290 |  \nFax: 617-582-6056  \nNOTE: This preprint reports new research that has not been certified by peer review and should not be used to guide clinical practice.  \nmedRxiv preprint doi: [https://doi.org/10.64898/2025.12.30.25343223](https://doi.org/10.64898/2025.12.30.25343223); this version posted December 31, 2025. The copyright holder for this preprint (which was not certified by peer review) is the author/funder, who has granted medRxiv a license to display the preprint in perpetuity.  \nIt is made available under a CC-BY-NC-ND 4.0 International license .  \nWord Count: 3773  \nFunding:  \nThis research was supported in part by grant R35HL161195 from the National Heart, Lung, and Blood Institute (NHLBI)/NIH, grant R01EB034586 from the National Institute of Biomedical Imaging and Bioengineering (NIBIB) and grant T32 HL094301 from the National Institutes of Health. The content is solely the responsibility of the authors and does not necessarily represent the official views of the NIH.  \nDisclosures:  \nDr. Jenifer M. Brown reports consulting fe","cbCaiptuGZPWROOP","https://ap.wps.com/l/cbCaiptuGZPWROOP","pdf",1317397,34,"English","# Age-and Sex-Adjusted Myocardial Flow Reserve Percentiles for Personalized Cardiovascular Risk Assessment\n## License and Preprint Status\n## Correspondence and Affiliations\n## Funding\n## Disclosures","[{\"question\":\"What is the study’s main focus?\",\"answer\":\"The preprint focuses on age-and sex–adjusted myocardial flow reserve percentiles intended for personalized cardiovascular risk assessment.\"},{\"question\":\"Is this medRxiv preprint peer reviewed?\",\"answer\":\"No. The document states it reports new research not certified by peer review and should not be used to guide clinical practice.\"},{\"question\":\"What funding sources support the research?\",\"answer\":\"Funding is reported from NHLBI/NIH (grant R35HL161195), NIBIB/NIH (grant R01EB034586), and additional NIH support (grant T32 HL094301).\"},{\"question\":\"What types of disclosures are included?\",\"answer\":\"Disclosures include consulting fees, software royalties, equity, speaker fees, and research grant support from multiple named organizations and institutions.\"}]","Age-and Sex-Adjusted Myocardial Flow Reserve Percentiles for Personalized Cardiovascular Risk Assessment | PDF",1790701932,86]