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Three years earlier, he had combined rhegmatogenous retinal detachment and vitreous hemorrhage treated with pars plana vitrectomy, 360° scleral buckling, and drainage retinotomy. On current examination, an orange-red subretinal mass connected to the prior scar was seen. Spectral-domain OCT showed severe subretinal fluid with type-2 CNV, and fundus fluorescein angiography confirmed active CNV. Monthly intravitreal aflibercept was given for four doses, leading to CNV regression with no recurrence at 20 months. Early diagnosis and intravitreal anti-VEGF therapy are essential for favorable outcomes and long-term remission.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/aflibercept-treatment-for-delayed-retinotomy-associated-choroidal-neovascularization-a-case-report-and-literature-review/456563/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/aflibercept-treatment-for-delayed-retinotomy-associated-choroidal-neovascularization-a-case-report-and-literature-review/456563.png","ImageObject",300,407,{"name":92,"@type":93},"dhado","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-30","2026-09-30",true,{"@type":102,"interactionType":103,"userInteractionCount":44},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What complication occurred after drainage retinotomy in this case?","Question",{"text":112,"@type":113},"The patient developed iatrogenic choroidal neovascularization (CNV) connected to the previous drainage retinotomy scar, manifesting years after the original surgery.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How was the diagnosis of CNV confirmed?",{"text":117,"@type":113},"Spectral-domain optical coherence tomography demonstrated severe subretinal fluid with type-2 CNV, and fundus fluorescein angiography showed active CNV.",{"name":119,"@type":110,"acceptedAnswer":120},"What treatment was used and what was the outcome?",{"text":121,"@type":113},"Monthly intravitreal aflibercept was administered. After four doses, the CNV regressed with no recurrence during 20 months of follow-up.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},456563,1790795147,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":44,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":19,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":52,"preview_page_count":4},5909893218464,"https://ap-avatar.wpscdn.com/davatar_085a072bc5b1113ac321206ff7593b45","| Access this article online |\n| --- |\n| Quick Response Code: |\n| |\n| Website:\u003Cbr>[http://journals.lww.com/TJOP](http://journals.lww.com/TJOP) |\n| DOI:\u003Cbr>10.4103/tjo.TJO-D-23-00072 |\n\n1Department of General Medicine, Shin Kong Wu Ho‑Su Memorial Hospital, Taipei, Taiwan, 2Department of Ophthalmology,  \nShin Kong Wu Ho‑Su Memorial Hospital, Taipei, Taiwan, 3Department of Ophthalmology, School of Medicine, National Taiwan University, Taipei, Taiwan, 4Department of Ophthalmology, School of Medicine, Fu Jen Catholic University, New Taipei, Taiwan  \n*Address for correspondence:  \nA/Prof. Cheng-Kuo Cheng, Department of Ophthalmology, Shin Kong Wu Ho-Su Memorial Hospital, No. 95, Wen Chang Road, Taipei, Taiwan.  \nE-mail: chengkuocheng.  \n[md@gmail.com](md@gmail.com)[ ](md@gmail.com)Submission: 25-05-2023  \nAccepted: 15-08-2023  \nPublished: 05-01-2024  \nCase Report  \nTaiwan J Ophthalmol 2025;15:655‑658  \nAflibercept treatment for delayed retinotomy‐associated choroidal neovascularization: A case report and literature review  \nCyuan‑Yi Yeh1, Yi‑Ting Liang2, Cheng‑Kuo Cheng2,3,4*  \nAbstract:  \nA 67‑year‑old male presented to our clinic with sudden onset of blurred vision and metamorphopsia of his left eye for 2 weeks. He had a history of combined rhegmatogenous retinal detachment and vitreous hemorrhage and underwent an uneventful pars plana vitrectomy, 360° scleral buckling, and drainage retinotomy for his left eye 3 years ago. The anatomic and visual outcomes after surgery were good, without complications. On examination during this visit, an orange–red subretinal mass connected to the previous drainage retinotomy scar was noted. Spectral‑domain optical coherence tomography revealed severe subretinal fluid with type‑2 choroidal neovascularization (CNV) mass at the superior nasal macular area in connection with the margin of the previous retinotomy scar. Fundus fluorescein angiography showed an active CNV. The patient underwent monthly intravitreal aflibercept in the left eye. After four doses of aflibercept, his CNV regressed with no recurrence on follow‑up at 20 months. In conclusion, iatrogenic CNV is a rare complication following uneventful vitreoretinal surgery and can develop years after the operation. It is crucial to early diagnose and treat it with intravitreal antivascular endothelial growth factor treatment for a favorable outcome and long‑term remission.  \nKeywords:  \nAflibercept, antivascular, case report, endothelial growth factor, iatrogenic choroidal neovascularization  \nIntroduction  \nChoroidal neovascularization (CNV)  \nrefers to the growth of abnormal blood vessels, which can be triggered by pathological conditions affecting the retinal pigment epithelium (RPE), Bruch’s membrane, and thechoriocapillaris. The most common condition associated with CNV is age‑related macular degeneration (AMD) .[1] Other recognized causes include pathologic myopia, presumed ocular histoplasmosis syndrome, angioid streaks, truama andidiopathic. [2‑5] Iatrogenic CNV, although less common at a rate of 0. 1%, can occur following various surgical procedures, such as cryotherapy, cataract extraction,  \nThis is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercialNoDerivatives 4.0 License (CC BY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.  \nFor reprints [contact:](contact: WKHLRPMedknow_reprints@wolterskluwer.com)[ WKHLRPMedknow_reprints@wolterskluwer.com](contact: WKHLRPMedknow_reprints@wolterskluwer.com)  \nepiretinal membrane peeling, drainage retinotomy, and extraretinal drainage of subretinal fluid (SRF) .[6] In this case report, we present a delayed development of subretinal CNV occurring 3 years after drainage retinotomy.  \nCase Presentation  \nA 67‑year‑old male presented to our clinic with sudden onset of blurred vision and metamorphopsia of his l","cbCaish6E58FnGaF","https://ap.wps.com/l/cbCaish6E58FnGaF","pdf",1122236,"English","# Case Report\n## Abstract\n## Keywords\n## Introduction\n## Choroidal neovascularization (CNV)\n## Case Presentation","[{\"question\":\"What complication occurred after drainage retinotomy in this case?\",\"answer\":\"The patient developed iatrogenic choroidal neovascularization (CNV) connected to the previous drainage retinotomy scar, manifesting years after the original surgery.\"},{\"question\":\"How was the diagnosis of CNV confirmed?\",\"answer\":\"Spectral-domain optical coherence tomography demonstrated severe subretinal fluid with type-2 CNV, and fundus fluorescein angiography showed active CNV.\"},{\"question\":\"What treatment was used and what was the outcome?\",\"answer\":\"Monthly intravitreal aflibercept was administered. After four doses, the CNV regressed with no recurrence during 20 months of follow-up.\"}]","Aflibercept treatment for delayed retinotomy-associated choroidal neovascularization - A case report and literature review | PDF",1790746387]