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This review consolidates current research applying WMH to PCa diagnosis and treatment, detailing clinical advantages and outlining future prospects. 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BMC Cancer (2024) 24:448 BMC Cancer  \n[https://doi.org/10.1186/s12885-024-12071-6](https://doi.org/10.1186/s12885-024-12071-6)  \nRESEARCH Open Access  \nAdvantage of whole-mount histopathology in prostate cancer: current applications and future prospects  \nLewei Duan 1,2,3†, Zheng Liu 1,2,3†, Fangning Wan 1,2,3* and Bo Dai 1,2,3*  \nAbstract  \nBackground Whole-mount histopathology (WMH) has been a powerful tool to investigate the characteristics of prostate cancer. However, the latest advancement ofWMH was yet under summarization. In this review, we offer a comprehensive exposition of current research utilizing WMH in diagnosing and treating prostate cancer (PCa), and summarize the clinical advantages of WMH and outlines potential on future prospects.  \nMethods An extensive PubMed search was conducted until February 26, 2023, with the search term “prostate”,“whole-mount”,“large format histology”, which was limited to the last 4 years. Publications included were restricted to those in English. Other papers were also cited to contribute a better understanding.  \nResults WMH exhibits an enhanced legibility for pathologists, which improved the efficacy of pathologic examination and provide educational value. It simplifies the histopathological registration with medical images, which serves as a convincing reference standard for imaging indicator investigation and medical image-based artificial intelligence (AI) . Additionally, WMH provides comprehensive histopathological information for tumor volume estimation, post-treatment evaluation, and provides direct pathological data for AI readers. It also offers complete spatial context for the location estimation of both intraprostatic and extraprostatic cancerous region.  \nConclusions WMH provides unique benefits in several aspects of clinical diagnosis and treatment of PCa. The utilization ofWMH technique facilitates the development and refinement of various clinical technologies. We believe that WMH will play an important role in future clinical applications.  \nKeywords Whole-mount histopathology, Prostate cancer, MRI, AI, Histopathology  \n†Lewei Duan and Zheng Liu contributed equally to this work.  \n*Correspondence: Fangning Wan [fnwan06@fudan.edu.cn](fnwan06@fudan.edu.cn)[ ](fnwan06@fudan.edu.cn)Bo Dai [bodai1978@126.com](bodai1978@126.com)  \n1Department of Urology, Fudan University Shanghai Cancer Center, 200032 Shanghai, China  \n2Department of Oncology, Shanghai Medical College, Fudan University, 200032 Shanghai, China  \n3Shanghai Genitourinary Cancer Institute, 200032 Shanghai, China  \n© The Author(s) 2024. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit [http://creativecommons.org/l](http://creativecommons.org/l)icenses/by/4.0/. The Creative Commons Public Domain Dedication waiver ([http://creativecommons.org/publicdomain/zero/1.0/](http://creativecommons.org/publicdomain/zero/1.0/)) applies to the data made available in this article, unless otherwise stated in a credit line to the data.  \nBackground  \nWhole-mount histopathology (WMH) is a histopathologic technique that enables the examination of the intact cross-section of prostatic specimen, which is not feasible with conventional histopathologic methods. WMH has been admit","cbCaiqCXjRASR6Jm","https://ap.wps.com/l/cbCaiqCXjRASR6Jm","pdf",3409229,13,"English","# Abstract\n# Background\n# Methods\n# Results\n# Conclusions","[{\"question\":\"What is whole-mount histopathology (WMH) and why is it important for prostate cancer research?\",\"answer\":\"WMH is a technique that examines the intact cross-section of the prostate specimen, which conventional methods cannot achieve. It enables a more comprehensive understanding of prostate cancer lesion morphology and spatial distribution, supporting classification and treatment planning.\"},{\"question\":\"How does the review describe the clinical advantages of WMH?\",\"answer\":\"The review highlights improved legibility for pathologists, more effective pathological examination, and simplified histopathological registration with medical images. It also supports tumor volume estimation, post-treatment evaluation, and spatial context for estimating intraprostatic and extraprostatic cancer regions.\"},{\"question\":\"What role does WMH have in future clinical applications, including AI?\",\"answer\":\"The review emphasizes that WMH provides direct pathological data suitable for AI readers and can serve as a reference standard for imaging-related indicator investigation. It concludes that WMH is expected to play an important role in future clinical applications.\"}]","Advantage of whole-mount histopathology in prostate cancer: current applications and future prospects | PDF",1789988759,33]