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Early detection of tumors paired with timely targeted therapy can slow deterioration, while nano-systems built on photodynamic materials have advanced both diagnosis and treatment. This review examines photosensitizer-based material design for integrating cancer diagnosis and anti-cancer therapy, covering organic and inorganic photosensitizers used in PDT, and dual-function photosensitive nanomaterials. It also summarizes optimization strategies to improve ROS release, imaging accuracy, therapeutic efficacy, and biosafety, supporting coordinated photosensitizer design and clinical translation.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/advancing-cancer-treatment-innovative-materials-in-pdt-and-diagnostic-integration/367537/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/advancing-cancer-treatment-innovative-materials-in-pdt-and-diagnostic-integration/367537.png","ImageObject",300,407,{"name":92,"@type":93},"Fahsai","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-28","2026-09-23",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",11,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"Why is integrated cancer diagnosis and therapy important?","Question",{"text":113,"@type":114},"Integrated approaches improve outcomes by enabling early detection and timely targeted treatment, helping impede rapid cancer deterioration.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"What materials does the review focus on for PDT-based theranostics?",{"text":118,"@type":114},"The review centers on photosensitizer-based materials, including organic and inorganic photosensitizers and photosensitive nanomaterials with dual diagnostic and therapeutic functions.",{"name":120,"@type":111,"acceptedAnswer":121},"How can nano-systems be optimized for better imaging and treatment?",{"text":122,"@type":114},"Strategies include enhancing tumor targeting, increasing accurate ROS release and imaging, and improving biosafety to align therapeutic efficacy with clinical translation.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},367537,1790263474,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":140,"language":141,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":142,"faqs":143,"seo_title":144,"seo_description":67,"update_tm":145,"read_time":26},549768702563,"https://ap-avatar.wpscdn.com/avatar/8000c4aa63b76e948b?x-image-process=image/resize,m_fixed,w_180,h_180&k=1786536092046926083","International Journal of Nanomedicine  \nOpen Access Full Text Article REVIEW  \nAdvancing Cancer Treatment: Innovative Materials in PDT and Diagnostic Integration  \nYanan Wang 1–3 , *, Chaohua Hu4 , *, Yangjia Li4 , Zhe-Sheng Chen 5 , Lei Zhang 2 , 3 , 6  \n1College of Life Sciences, Fujian Agriculture and Forestry University, Fuzhou, 350002, People’s Republic of China; 2State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, 350108, People’s Republic of China; 3Fujian College, University of Chinese Academy of Sciences, Fuzhou, 350108, People’s Republic of China; 4National Engineering Research Center for Sugarcane, Fujian Agriculture and Forestry University, Fuzhou, 350002, People’s Republic of China; 5Department of Pharmaceutical Sciences, College of Pharmacy and Health Sciences, St. John’s University, Queens, NY, 11439, USA; 6University of Chinese Academy of Sciences, Beijing, 100049, People’s Republic of China  \n*These authors contributed equally to this work  \nCorrespondence: Lei Zhang, State Key Laboratory of Structural Chemistry, Fujian Institute of Research on the Structure of Matter, Chinese Academy of Sciences, Fuzhou, 350108, People’s Republic of China, Email [zhangl@fjirsm.ac.cn](zhangl@fjirsm.ac.cn)  \nAbstract: The diagnosis and treatment of cancers have become a significant challenge in overcoming malignant diseases. Early detection of tumors and timely targeted therapy can greatly impede the rapid deterioration of cancers. In recent years, nano-systems based on photodynamic materials have shown great progress in tumor diagnosis and treatment applications. With the continuous exploration of tumor-specific targets and the development of photodynamic nanoparticles, the generation of new nanoparticles that are target-specific, highly sensitive, and biosafe for integrated diagnosis and therapy is realistic. This review introduces the rational basis for photosensitizer-based materials for integrating cancer diagnosis and anti-cancer therapy, types and characteristics of organic and inorganic photosensitizers currently used for PDT treatment, photosensitive nano-materials with dual detection and therapeutic properties the advancement in developing photo-dynamic nano-systems showing potential in integrated diagnosis and therapeutic applications. We also introduce current strategies for optimizing nano-systems with the properties for enhancing targeting ROS release and accurate imaging, combining therapeutic efficacy, as well as biosafety of the integrative materials for PDT application, providing references for the coordinated optimization of photosensitizer design and clinical translation.  \nPlain Language Summary: The integration of PDT with advanced diagnostic modalities represents a transformative approach in cancer theranostics, as evidenced by the comprehensive exploration of photosensitizer-based nanomaterials in this review. By leveraging the unique photophysical properties of organic and inorganic photosensitizers, researchers have developed innovative nano-systems capable of simultaneous tumor detection and targeted therapy. Key advancements include the rational design of aggregation-induced emission photosensitizers (AIE-PS) with redshifted absorption spectra, hypoxia-responsive nanomaterials for enhanced ROS generation, and multifunctional composites such as UCNP@MOF hybrids that address tumor microenvironment limitations. These systems demonstrate improved targeting precision, reduced off-target effects, and synergistic therapeutic outcomes when combined with chemotherapy or immunotherapy. Despite these strides, challenges persist in optimizing light penetration depth, mitigating photobleaching, and ensuring biosafety during clinical translation. The development of oxygen-independent Type III photosensitizers and stimuli-responsive delivery systems offers promising avenues to overcome hypoxia-related barriers. Furthermore, the ","cbCaid1ANdpyyuQP","https://ap.wps.com/l/cbCaid1ANdpyyuQP","pdf",12158717,24,"English","# Introduction\n# Abstract\n## Plain Language Summary\n# Keywords\n# Publication Information","[{\"question\":\"Why is integrated cancer diagnosis and therapy important?\",\"answer\":\"Integrated approaches improve outcomes by enabling early detection and timely targeted treatment, helping impede rapid cancer deterioration.\"},{\"question\":\"What materials does the review focus on for PDT-based theranostics?\",\"answer\":\"The review centers on photosensitizer-based materials, including organic and inorganic photosensitizers and photosensitive nanomaterials with dual diagnostic and therapeutic functions.\"},{\"question\":\"How can nano-systems be optimized for better imaging and treatment?\",\"answer\":\"Strategies include enhancing tumor targeting, increasing accurate ROS release and imaging, and improving biosafety to align therapeutic efficacy with clinical translation.\"}]","Advancing Cancer Treatment - Innovative Materials in PDT and Diagnostic Integration | PDF",1790171265]