[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-379044-105":59,"doc-detail-379044-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","advancing-cancer-research-current-knowledge-on-cutaneous-neoplasia","Advancing Cancer Research: Current Knowledge on Cutaneous Neoplasia","","Skin cancers require a multidisciplinary approach. Updated guidelines provide new insights for managing these diseases, emphasizing melanoma as a malignant melanocytic tumor with four major histological subtypes and ongoing lethality. The mortality–incidence ratio is higher in Eastern than Western Europe, highlighting the need for improved prevention and early detection. Basal cell and squamous cell carcinomas remain the leading skin cancers with rising incidence; diagnosis relies on biopsy. Sebaceous carcinoma is uncommon but aggressive, needs early treatment, and is managed primarily with surgery, including Mohs micrographic surgery.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/advancing-cancer-research-current-knowledge-on-cutaneous-neoplasia/379044/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/advancing-cancer-research-current-knowledge-on-cutaneous-neoplasia/379044.png","ImageObject",300,407,{"name":92,"@type":93},"WPS_1786070896","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-09-25","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":8},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"Why do skin cancers require a multidisciplinary approach?","Question",{"text":112,"@type":113},"The review emphasizes that optimal management across different skin cancer types depends on coordinated expertise, including dermatology, medical oncology, and radiation oncology.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How is melanoma diagnosis and staging approached?",{"text":117,"@type":113},"Suspicious pigmented lesions should be evaluated using clinical examination and dermoscopy, with diagnosis based on full-thickness excisional biopsy. Staging and risk assessment are defined by disease characteristics at diagnosis.",{"name":119,"@type":110,"acceptedAnswer":120},"What is the primary treatment strategy for sebaceous carcinoma?",{"text":121,"@type":113},"Sebaceous carcinoma is treated mainly with surgical methods, including Mohs micrographic surgery, which supports complete margin evaluation and low recurrence rates.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},379044,1790319075,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":8,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},549768072016,"https://ap-avatar.wpscdn.com/davatar_155a257f0dc6eb9ab79c44ca47cae57d","Review  \nAdvancing Cancer Research: Current Knowledge on Cutaneous Neoplasia  \nLaura St«tescu 1, Laura Mihaela Trandafir 2, Elena T, arc« 3, *, Mihaela Moscalu 4,  \nMaria Magdalena Leon Constantin 5, L«cr«mioara Ionela Butnariu 2, Mioara Florentina Trandafirescu 6, Mihaela Camelia Tîrnovanu 2,*, Rodica Heredea 7, Andrei Valentin P«tras, cu 6, Doru Botezat 4 and Elena Cojocaru 6  \nCitation: St˘atescu, L.; Trandafir, L.M.; T, arc˘a, E.; Moscalu, M.;  \nLeon Constantin, M.M.; Butnariu, L.I.; Trandafirescu, M.F.; Tîrnovanu, M.C.; Heredea, R.; P˘atras, cu, A.V.; et al. Advancing Cancer Research: Current Knowledge on Cutaneous Neoplasia. Int. J. Mol. Sci. 2023, 24, 11176 . [https://doi.org/10.3390/](https://doi.org/10.3390/)[ ](https://doi.org/10.3390/)ijms241311176  \nAcademic Editor: Takamichi Ito  \nReceived: 23 May 2023  \nRevised: 3 July 2023  \nAccepted: 4 July 2023  \nPublished: 6 July 2023  \nCopyright: © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://](https://)[ ](https://)[creativecommons.org/licenses/by/](creativecommons.org/licenses/by/)[ ](creativecommons.org/licenses/by/)[4.0/](4.0/)) .  \n1 Medical III Department, Faculty of Medicine,“Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, Romania; laura.statescu@umfi[asi.ro](asi.ro)  \n2 Department of Mother and Child, Faculty of Medicine,“Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, Romania; laura.trandafir@umfi[asi.ro](asi.ro) (L.M.T.); ionela.butnariu@umfi[asi.ro](asi.ro) (L.I.B.)  \n3 Department of Surgery II—Pediatric Surgery,“Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, Romania  \n4 Department of Preventive Medicine and Interdisciplinarity,“Grigore T. Popa” University of Medicine and Pharmacy, 16 University Street, 700115 Iasi, Romania; [moscalu.mihaela@gmail.com](moscalu.mihaela@gmail.com) (M.M.);  \ndoru.botezat@umfi[asi.ro](asi.ro) (D.B.)  \n5 Medical I Department, Faculty of Medicine,“Grigore T. Popa” University of Medicine and Pharmacy, 700115 Iasi, Romania; [leon_mariamagdalena@yahoo.com](leon_mariamagdalena@yahoo.com)  \n6 Department of Morphofunctional Sciences I–Pathology,“Grigore T. Popa” University of Medicine and Pharmacy, 700115 Ias, i, Romania; mioaratrandafi[rescu@yahoo.co.uk](rescu@yahoo.co.uk) (M.F.T.); [andrei-valentin-a-patrascu@email.um](andrei-valentin-a-patrascu@email.um)fi[asi.ro](asi.ro) (A.V.P.); elena2.cojocaru@umfi[asi.ro](asi.ro) (E.C.)  \n7 Department of Clinical Practical Skills,“Victor Babe¸s” University of Medicine and Pharmacy,  \n300041 Timisoara, Romania; elena-rodica.heredea@umft.ro  \n* Correspondence: elena.tuluc@umfi[asi.ro](asi.ro) (E.T, .); mihaela.tirnovanu@umfi[asi.ro](asi.ro) (M.C.T.)  \nAbstract: Skin cancers require a multidisciplinary approach. The updated guidelines introduce new insights into the management of these diseases. Melanoma (MM), the third most common skin cancer, a malignant melanocytic tumor, which is classified into four major histological subtypes, continues to have the potential to be a lethal disease. The mortality–incidence ratio is higher in Eastern European countries compared to Western European countries, which shows the need for better prevention and early detection in Eastern European countries. Basal cell carcinoma (BCC) and squamous cell carcinoma (cSCC) remain the top two skin cancers, and their incidence continues to grow. The gold standard in establishing the diagnosis and establishing the histopathological subtype in BCC and SCC is a skin biopsy. Sebaceous carcinoma (SeC) is an uncommon and potentially aggressive cutaneous malignancy showing sebaceous differentiation. It accounts for 0.7% of skin cancers and 3–6.7% of cancer-related deaths. Due to the rapid extension to the regional lymph nodes, SeC requires early treatment. The main treatment for sebaceous carcinoma is surgical treatment, including Mohs microgr","cbCaisnFpTjWyudO","https://ap.wps.com/l/cbCaisnFpTjWyudO","pdf",462660,27,"English","# Introduction\n## Melanoma and risk assessment\n## Non-melanoma skin cancers\n## Sebaceous carcinoma\n## Cutaneous T and B cell lymphomas\n## Multidisciplinary management","[{\"question\":\"Why do skin cancers require a multidisciplinary approach?\",\"answer\":\"The review emphasizes that optimal management across different skin cancer types depends on coordinated expertise, including dermatology, medical oncology, and radiation oncology.\"},{\"question\":\"How is melanoma diagnosis and staging approached?\",\"answer\":\"Suspicious pigmented lesions should be evaluated using clinical examination and dermoscopy, with diagnosis based on full-thickness excisional biopsy. Staging and risk assessment are defined by disease characteristics at diagnosis.\"},{\"question\":\"What is the primary treatment strategy for sebaceous carcinoma?\",\"answer\":\"Sebaceous carcinoma is treated mainly with surgical methods, including Mohs micrographic surgery, which supports complete margin evaluation and low recurrence rates.\"}]","Advancing Cancer Research: Current Knowledge on Cutaneous Neoplasia | PDF",1790233843,68]