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Chaperonin containing TCP-1 subunit 3 (CCT3) is a molecular chaperone subunit that supports protein folding and remodeling, maintaining protein homeostasis via substrates such as tubulin and actin.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/advances-in-the-study-of-cct3-in-malignant-tumors-a-review/370248/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/advances-in-the-study-of-cct3-in-malignant-tumors-a-review/370248.png","ImageObject",300,407,{"name":42,"@type":43},"Ivy","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-27","2026-09-23",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",10,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What is CCT3 and what role does it play in protein homeostasis?","Question",{"text":63,"@type":64},"CCT3 is a subunit of the chaperonin containing TCP-1 complex, a molecular chaperone involved in protein folding and remodeling. 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Tumorigenesis is a complex process involving multiple factors, genes, and pathways. Tumor cells are characterized by abnormal proliferation, infiltration, invasion, and metastasis. Improving tumor diagnosis rates and identifying novel molecular therapeutic targets are of great significance for the advancement of modern medicine. Chaperonin containing TCP-1 subunit 3 (CCT3) is oneof the subunits of the chaperonin containing TCP-1 complex, a molecular chaperone involved in protein folding and remodeling. CCT3 plays a crucial role in maintaining protein homeostasis, with key substrates including tubulin and actin. In recent years, CCT3 has been reported to be abnormally expressed in various cancers, correlating with prognosis and therapeutic outcomes. In this review, we summarize the basic structure and function of chaperonin containing TCP-1 complex and CCT3, and discuss the role of CCT3 in tumor development. Additionally, we explore its potential applications in cancer diagnosis and treatment. |\n| --- |\n| Abbreviations: CCT = TCP-1-containing chaperonin, CCT3 = chaperonin containing TCP-1 subunit 3 , CDC20 = cell division cycle protein 20, CRC = colorectal cancer, DBD = DNA-binding domain, HCC = hepatocellular carcinoma, HPV = human papillomavirus, HSPs = heat shock proteins, LUAD = lung adenocarcinoma, mTOR = mammalian target of rapamycin, MM = multiple myeloma, STAT3 = signal transducer and activator of transcription 3, VHL = Von Hippel–Lindau. |\n| Keywords: cancer, CCT, CCT3 , research progress, tumor marker |\n\n1. Introduction  \nThe protein homeostasis network refers to the balanced state achieved during the synthesis, folding, transport, aggregation, disaggregation, and degradation of proteins after their release from ribosomes. Molecular chaperones are critical mediatorsin protein homeostasis; they prevent adverse interactions that can arise during translation by shielding exposed hydrophobic amino acid residues. This prevents the formation of misfolded structures and enables the degradation or remodeling of incorrectly structured proteins, thus maintaining protein stability. Utilizing the energy derived from nucleotide binding and ATP hydrolysis, molecular chaperones enclose misfolded proteins within their central cavity, allowing them to fold correctly in isolation. [1] Newly synthesized polypeptides typically engage in nonspecific interactions, and in the absence of chaperonin containing TCP-1 complex (CCT), they are prone to aggregation, leading to toxicity. Importantly, molecular chaperones are not part of the final functional structure of the proteins they assist. Molecular chaperones are products of a highly conserved gene family and are ubiquitous across various organisms. They play vital roles not only in protein folding  \nbut also in DNA replication, transcription, cytoskeletal dynamics, and signal transduction. [2] The most significant of these is chaperonin, which exists as large complexes of approximately 1 MDa, primarily composed of 2 stacked oligomeric rings of 7 to 9 subunits, each featuring a central cavity structure. Each subunit consists of 3 domains: (1) the apical domain (A domain), responsible for substrate recognition and binding; (2) the equatorial domain (E domain), which binds ATP and forms inter-ring contacts; (3) the intermediate domain (I domain), which conveys conformational information between the first 2 domains. [3] The intermediate and equatorial domains have highly conserved sequences, with variation primarily occurring in the apical domain. Molecular chaperonins are commonly classified into type I and type II. Type I chaperonins, found in bacteri","cbCaitfZKnUaRqam","https://ap.wps.com/l/cbCaitfZKnUaRqam","pdf",583541,"English","# Abstract\n# Abbreviations\n# 1. Introduction\n# 2. Structure and function of CCT and CCT3","[{\"question\":\"What is CCT3 and what role does it play in protein homeostasis?\",\"answer\":\"CCT3 is a subunit of the chaperonin containing TCP-1 complex, a molecular chaperone involved in protein folding and remodeling. It maintains protein homeostasis with key substrates including tubulin and actin.\"},{\"question\":\"Why is studying CCT3 in malignant tumors important?\",\"answer\":\"CCT3 has been reported to be abnormally expressed in multiple cancers, correlating with prognosis and therapeutic outcomes. Understanding its role can support cancer diagnosis and treatment target discovery.\"},{\"question\":\"What are the key cellular features of tumor development described in the review?\",\"answer\":\"Tumor cells are characterized by abnormal proliferation, infiltration, invasion, and metastasis, reflecting a complex tumorigenesis process involving multiple factors, genes, and pathways.\"}]","Advances in the study of CCT3 in malignant tumors - A review | PDF",1790187604,23]