[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-366168-105":59,"doc-detail-366168-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","advances-in-hybrid-hydrogel-design-for-biomedical-applications-innovations-in-drug-delivery-and-tissue-engineering-for-gynecological-cancers","Advances in hybrid hydrogel design for biomedical applications: innovations in drug delivery and tissue engineering for gynecological cancers","","Hybrid hydrogels function as multifunctional biomaterials that support targeted drug delivery and tissue engineering across gynecologic oncology. This review synthesizes recent design advances using hybrid combinations of polymer networks and nanomaterials to enable tunable stimuli-responsiveness, improved mechanical performance, and better biocompatibility. Preclinical examples include folate-conjugated liposomal doxorubicin and growth factor–loaded hydrogel scaffolds for ovarian and endometrial repair. It also examines optimization of loading, tumor-triggered spatiotemporal release, patient-specific scaffold architecture, and future integrated monitoring and chemo-immunotherapy strategies.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/advances-in-hybrid-hydrogel-design-for-biomedical-applications-innovations-in-drug-delivery-and-tissue-engineering-for-gynecological-cancers/366168/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/advances-in-hybrid-hydrogel-design-for-biomedical-applications-innovations-in-drug-delivery-and-tissue-engineering-for-gynecological-cancers/366168.png","ImageObject",300,407,{"name":92,"@type":93},"Nguyễn Văn Học","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-29","2026-09-23",true,{"@type":102,"interactionType":103,"userInteractionCount":56},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What problems in gynecological cancer treatment motivate hybrid hydrogel research?","Question",{"text":112,"@type":113},"Conventional surgery can leave microscopic residual disease, chemotherapy can cause systemic toxicity and drug resistance, and radiotherapy may damage surrounding healthy tissues. Tumor heterogeneity and complex microenvironments further limit existing options, motivating more effective and less toxic approaches.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How do hybrid hydrogels improve drug delivery in gynecological cancers?",{"text":117,"@type":113},"They combine polymer networks with nanomaterials to create tunable stimuli-responsive systems. Designs can optimize drug loading and control spatiotemporal release in response to tumor cues such as pH or enzyme activity, supporting localized exposure at tumor sites.",{"name":119,"@type":110,"acceptedAnswer":120},"What tissue engineering functions do these hydrogel scaffolds provide?",{"text":121,"@type":113},"Hydrogel scaffolds can be engineered to support regenerative repair after interventions, including providing cues that promote pelvic tissue regeneration. Growth factor–loaded scaffold strategies are discussed as supportive of endometrial repair in animal models.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},366168,1790380860,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":56,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},1374402739827,"https://ap-avatar.wpscdn.com/avatar/14000c97e7351f1a627?x-image-process=image/resize,m_fixed,w_180,h_180&k=1787885694763230660","Cell Biol Toxicol (2025) 41:115  \n[https://doi.org/10.1007/s10565-025-10064-0](https://doi.org/10.1007/s10565-025-10064-0)  \nAdvances in hybrid hydrogel design for biomedical applications: innovations in drug delivery and tissue engineering for gynecological cancers  \nHua Chang · Heng Wei · Yue Qi · Silu Ding · Hui Li · Si Si  \nReceived: 27 March 2025 / Accepted: 22 June 2025  \n© The Author(s) 2025  \nAbstract Hybrid hydrogels have emerged as multifunctional biomaterials for targeted drug delivery and tissue engineering in gynecologic oncology. In this review, we summarize recent advances in the design of hybrid hydrogels that combine polymer networks with nanomaterials to achieve tunable stimuliresponsiveness, enhanced mechanical strength, and improved biocompatibility. For example, preclinical studies of folate‐conjugated liposomal doxorubicin have demonstrated enhanced accumulation and antitumor efficacy in ovarian cancer models, while growth factor–loaded hydrogel scaffolds have supported endometrial repair in rodent models. We  \nHua Chang, Heng Wei, Yue Qi these authors contributed equally to this work.  \nH. Chang · H. Li (*)  \nDepartment Gynecology, The First Hospital of China Medical University, Shenyang, Liaoning, China  \ne-mail: [yidalihui@163.com](yidalihui@163.com)  \n[H. Wei](H. Wei) · Y. Qi  \nDepartment of Obstetrics and Gynecology, Shengjing Hospital of China Medical University, Liaoning, China  \nS. Ding (*)  \nDepartment of Radiation Oncology, The First Hospital of China Medical University, Shenyang, China  \ne-mail: [dsl1108@hotmail.com](dsl1108@hotmail.com)  \nS. Si (*)  \nDepartment of Obstetrics, The First Hospital of China Medical University, Shenyang, China  \ne-mail: [ss_cmu@yeah.net](ss_cmu@yeah.net)  \ndiscuss strategies for optimizing drug loading, controlling spatiotemporal release profiles in response to tumor‐specific cues (such as pH or enzyme activity), and customizing scaffold architecture for patient‐specific regenerative needs. Implementation challenges—including efficient encapsulation of multiple cargos, precise control over degradation rates, and scale‐up for clinical manufacturing—are critically examined. Finally, we outline future directions, including multifunctional platforms that integrate real‐time monitoring with combined chemo‐immunotherapy and approaches to address regulatory and translation hurdles. This evidence‐based analysis highlights how hybrid hydrogels can advance precision therapy and regenerative medicine for gynecologic cancers while there is a need for further validation in clinical settings.  \nHighlights (1) Hybrid hydrogels integrate polymer networks and nanomaterials for tunable, stimuli-responsive drug delivery in ovarian and cervical cancer.  \n(2) Localized implantation ensures sustained chemotherapeutic concentration at residual tumor sites, reducing systemic toxicity.  \n(3) Nanoparticle-reinforced scaffolds support pelvic tissue regeneration post-resection while providing immunomodulatory cues.  \n(4) Multifunctional platforms combine real-time imaging and chemo-immunotherapy for precision gynecologic oncology.  \nKeywords Hybrid hydrogels · Drug delivery · Tissue engineering · Gynecological cancers  \nIntroduction  \nGynecological cancers are malignant neoplasms of the female reproductive tract, including ovarian, cervical, endometrial (uterine), vulvar, and vaginal cancers. Among these, ovarian and cervical cancers are the most prevalent and pose significant health risks to women worldwide (Hollis 2023 ; Nebgen et al. 2019) . Ovarian cancer, often diagnosed at a late stage due to non-specific symptoms, remains the most lethal gynecological disease(Karnezis et al. 2017) . Cervical cancer patients usually contracted persistent highrisk human papillomavirus (HPV), which has seen a decline in incidence due to screening programs and HPV vaccination. However, cervical cancer still represents a major health burden in worldwide low-and middle-income countries (Burd 2003 ; Sharma et","cbCaigel55ePFRT1","https://ap.wps.com/l/cbCaigel55ePFRT1","pdf",2681767,31,"English","# Introduction\n## Overview of gynecological cancers and treatment challenges\n## Targeting and stimuli-responsive strategies in drug delivery\n# Advances in hybrid hydrogel design\n## Hybrid polymer–nanomaterial networks for tunable responses\n## Strategies for drug loading and controlled release\n# Tissue engineering applications\n## Scaffold architecture and regenerative support\n## Immunomodulatory cues and post-resection regeneration\n# Future directions\n## Multifunctional real-time monitoring platforms\n## Combined chemo-immunotherapy and translational hurdles","[{\"question\":\"What problems in gynecological cancer treatment motivate hybrid hydrogel research?\",\"answer\":\"Conventional surgery can leave microscopic residual disease, chemotherapy can cause systemic toxicity and drug resistance, and radiotherapy may damage surrounding healthy tissues. Tumor heterogeneity and complex microenvironments further limit existing options, motivating more effective and less toxic approaches.\"},{\"question\":\"How do hybrid hydrogels improve drug delivery in gynecological cancers?\",\"answer\":\"They combine polymer networks with nanomaterials to create tunable stimuli-responsive systems. Designs can optimize drug loading and control spatiotemporal release in response to tumor cues such as pH or enzyme activity, supporting localized exposure at tumor sites.\"},{\"question\":\"What tissue engineering functions do these hydrogel scaffolds provide?\",\"answer\":\"Hydrogel scaffolds can be engineered to support regenerative repair after interventions, including providing cues that promote pelvic tissue regeneration. Growth factor–loaded scaffold strategies are discussed as supportive of endometrial repair in animal models.\"}]","Advances in hybrid hydrogel design for biomedical applications: innovations in drug delivery and tissue engineering for gynecological cancers | PDF",1790164035,78]