[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-332894-105":59,"doc-detail-332894-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","advances-in-a-to-i-rna-editing-in-cancer","Advances in A-to-I RNA editing in cancer","","RNA modifications are widespread across the mammalian transcriptome and are central to controlling cellular processes. Multiple cancers are strongly associated with these modifications, particularly adenosine-to-inosine (A-to-I) editing driven by ADAR enzymes acting on double-stranded RNA. With improvements in RNA sequencing, A-to-I editing patterns in tumors are increasingly recognized, showing distinct site- and level-level alterations linked to tumor progression. Editing in coding and noncoding regions shapes cancer via amino-acid changes, dsRNA immunogenicity, miRNA–mRNA interactions, and circular RNA splicing and lncRNA function. A comprehensive view supports advances in diagnosis, therapy, and prognosis, and highlights regulatory mechanisms, clinical applications, current research, future directions, and therapeutic implications.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/advances-in-a-to-i-rna-editing-in-cancer/332894/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/advances-in-a-to-i-rna-editing-in-cancer/332894.png","ImageObject",300,407,{"name":92,"@type":93},"Genevieve","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-23","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":19},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is adenosine-to-inosine (A-to-I) RNA editing and what enzyme performs it?","Question",{"text":112,"@type":113},"A-to-I editing is a prevalent RNA modification in human cells where adenosine in double-stranded RNA is converted to inosine. This reaction is catalyzed by adenosine deaminases acting on RNA (ADAR) enzymes.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How does A-to-I editing relate to cancer progression?",{"text":117,"@type":113},"A-to-I editing levels and specific sites are altered in many malignant tumors. It can promote or suppress cancer by inducing amino-acid mutations, changing dsRNA immunogenicity, modulating miRNA–mRNA interactions, and affecting splicing and function of circular RNAs and long non-coding RNAs.",{"name":119,"@type":110,"acceptedAnswer":120},"Why is understanding A-to-I RNA editing important for clinical applications?",{"text":121,"@type":113},"The review argues that a comprehensive understanding helps advance diagnosis, treatment, and prognosis of human cancers. It also summarizes potential therapeutic implications and future research directions.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},332894,1790204086,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":19,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145,"preview_page_count":4},1374391974585,"https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c","Zhang et al. Molecular Cancer (2024) 23:280 [https://doi.org/10.1186/s12943-024-02194-6](https://doi.org/10.1186/s12943-024-02194-6)  \nMolecular Cancer  \nREVIEW Open Access  \nAdvances in A-to-I RNA editing in cancer  \nYi Zhang 1,2†, Lvyuan Li 1,2†, Juana Jessica Mendoza 1,2, Dan Wang 1,2, Qijia Yan3, Lei Shi4, Zhaojian Gong4, Zhaoyang Zeng 1,2,5, Pan Chen 1,2,5* and Wei Xiong 1,2,5*  \nAbstract  \nRNA modifications are widespread throughout the mammalian transcriptome and play pivotal roles in regulating various cellular processes. These modifications are strongly linked to the development of many cancers. One of the most prevalent forms of RNA modifications in humans is adenosine-to-inosine (A-to-I) editing, catalyzed by the enzyme adenosine deaminase acting on RNA (ADAR) in double-stranded RNA (dsRNA) . With advancementsin RNA sequencing technologies, the role of A-to-I modification in cancer has garnered increasing attention. Research indicates that the levels and specific sites of A-to-I editing are significantly altered in many malignant tumors, correlating closely with tumor progression. This editing occurs in both coding and noncoding regions of RNA, influencing signaling pathways involved in cancer development. These modifications can either promote or suppress cancer progression through several mechanisms, including inducing non-synonymous amino acid mutations, altering the immunogenicity of dsRNAs, modulating mRNA interactions with microRNAs (miRNAs), and affecting the splicing of circular RNAs (circRNAs) as well as the function of long non-coding RNAs (lncRNAs) . A comprehensive understanding of A-to-I RNA editing is crucial for advancing the diagnosis, treatment, and prognosis of human cancers. This review explores the regulatory mechanisms of A-to-I editing in cancers and examines their potential clinical applications. It also summarizes current research, identifies future directions, and highlights potential therapeutic implications.  \nKeywords RNA modification, A-to-I editing, Malignant tumor, ADAR, dsRNA  \n†Yi Zhang and Lvyuan Li contributed equally to this work.  \n*Correspondence: Pan Chen[chenpan08@csu.edu.cn](chenpan08@csu.edu.cn)[ ](chenpan08@csu.edu.cn)Wei Xiong [xiongwei@csu.edu.cn](xiongwei@csu.edu.cn)  \n1NHC Key Laboratory of Carcinogenesis and Hunan Key Laboratory of Cancer Metabolism, Hunan Cancer Hospital and the Affiliated Cancer Hospital of Xiangya School of Medicine, Central South University, Changsha, Hunan 410078, China  \n2Key Laboratory of Carcinogenesis and Cancer Invasion of the Chinese Ministry of Education, Cancer Research Institute, School of Basic Medicine Sciences, Central South University, Changsha, Hunan 410078, China 3Department of Pathology, Xiangya Hospital, Central South University, Changsha, Hunan 410008, China  \n4Department of Oral and Maxillofacial Surgery, The Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, China 5Furong Laboratory, Changsha, Hunan 410078, China  \nBackground  \nRNA modifications play a crucial role in regulating various aspects of RNA function, including splicing, stability, localization, translation, and interactions with other RNA molecules and proteins. These modifications serve as key regulators of cellular physiology, and their alterations are closely associated with the onset and progression of numerous diseases, particularly malignant tumors [1, 2]. Several types of RNA modifications have been implicated in cancer development [3], such as N6-methyladenosine (m6A), N1-methyladenosine (m1A), 5-methylcytidine (m5C), N7-methylguanosine (m7G), pseudouridine (Ψ), and adenosine-to-inosine (A-to-I) editing [3–5]. Among these, A-to-I editing is especially prevalent in human cells. Research indicates that changes in A-to-I editing in cancer cells may promote tumor growth and confer  \n© The Author(s) 2024. Open Access This article is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License, which pe","cbCaioGy1pQJFf5U","https://ap.wps.com/l/cbCaioGy1pQJFf5U","pdf",1568271,13,"English","# Background\n## Role of RNA modifications in disease and cancer\n## Overview of major RNA modification types\n# A-to-I RNA editing\n## ADAR enzymes and dsRNA substrates\n## ADAR isoforms and subcellular localization\n# Mechanistic links to cancer progression\n## Effects on splicing, stability, and RNA interactions\n## Consequences for immunogenicity and protein coding","[{\"question\":\"What is adenosine-to-inosine (A-to-I) RNA editing and what enzyme performs it?\",\"answer\":\"A-to-I editing is a prevalent RNA modification in human cells where adenosine in double-stranded RNA is converted to inosine. This reaction is catalyzed by adenosine deaminases acting on RNA (ADAR) enzymes.\"},{\"question\":\"How does A-to-I editing relate to cancer progression?\",\"answer\":\"A-to-I editing levels and specific sites are altered in many malignant tumors. It can promote or suppress cancer by inducing amino-acid mutations, changing dsRNA immunogenicity, modulating miRNA–mRNA interactions, and affecting splicing and function of circular RNAs and long non-coding RNAs.\"},{\"question\":\"Why is understanding A-to-I RNA editing important for clinical applications?\",\"answer\":\"The review argues that a comprehensive understanding helps advance diagnosis, treatment, and prognosis of human cancers. It also summarizes potential therapeutic implications and future research directions.\"}]","Advances in A-to-I RNA editing in cancer | PDF",1789999875,33]