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This review highlights phage display technology as a key enabling platform, using phage–peptide libraries to discover ligands that specifically recognize cancer cell markers. The approach supports precision-targeted immunodiagnostics and therapeutics, including targeted drug delivery systems, aiming to improve treatment accuracy and efficacy while reducing adverse effects. ",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/advancements-in-ovarian-cancer-immunodiagnostics-and-therapeutics-via-phage-display-technology-review/339503/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/advancements-in-ovarian-cancer-immunodiagnostics-and-therapeutics-via-phage-display-technology-review/339503.png","ImageObject",300,407,{"name":92,"@type":93},"Hazel","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-08","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":29},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"Why is early detection of ovarian cancer difficult?","Question",{"text":112,"@type":113},"Early detection is hampered by limitations of current screening methods, and many patients are diagnosed at late stages due to subtle, non-specific symptoms.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What role does phage display technology play in ovarian cancer management?",{"text":117,"@type":113},"Phage display technology uses phage–peptide libraries to identify ligands with specificity for cancer cell markers, enabling precision-targeted immunodiagnostic and therapeutic strategies.",{"name":119,"@type":110,"acceptedAnswer":120},"How can targeted approaches improve outcomes while reducing harm?",{"text":121,"@type":113},"By focusing on targeted drug delivery systems and precision-directed therapies, the review emphasizes improved treatment accuracy and efficacy while aiming to minimize adverse effects.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},339503,1790680997,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":29,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},137441390410,"https://ap-avatar.wpscdn.com/avatar/2000252f4ab5702993?_k=1776741390130283984","TYPE Review  \nPUBLISHED 28 May 2024  \nDOI 10.3389/fimmu.2024.1402862  \nOPEN ACCESS  \nEDITED BY  \nAnand Rotte,  \nArcellx Inc, United States  \nREVIEWED BY  \nFortunato Ferrara, Specifica Inc, United States Sherry Wu,  \nThe University of Queensland, Australia Rosendo Luria-Perez,  \nChildren ’s Hospital of Mexico Federico Gomez, Mexico  \n*CORRESPONDENCE Wei-hua Tong  \n [tongwh@jlu.edu.cn](tongwh@jlu.edu.cn)  \nRECEIVED 18 March 2024  \nACCEPTED 13 May 2024  \nPUBLISHED 28 May 2024  \nCITATION  \nLi Y, Li X-m, Yang K-d and Tong W-h (2024) Advancements in ovarian cancer immunodiagnostics and therapeutics via phage display technology.  \nFront. Immunol. 15:1402862 .  \ndoi: 10.3389/fimmu.2024.1402862  \nCOPYRIGHT  \n© 2024 Li, Li, Yang and Tong. This is an openaccess article distributed under the terms of the Creative Commons Attribution License (CC BY) . The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.  \nAdvancements in ovarian cancer  \nimmunodiagnostics and therapeutics via phage display technology  \nYang Li 1,2, Xiao-meng Li 2, Kai-di Yang 2 and Wei-hua Tong 1*  \n1Obstetrics and Gynecology Center, First Hospital of Jilin University, Changchun, Jilin, China, 2 Department of Rehabilitation, School of Nursing, Jilin University, Changchun, China  \nOvarian cancer, ranking as the seventh most prevalent malignancy among women globally, faces significant challenges in diagnosis and therapeutic intervention. The difficulties in early detection are amplified by the limitations and inefficacies inherent in current screening methodologies, highlighting a pressing need for more efficacious diagnostic and treatment strategies. Phage display technology emerges as a pivotal innovation in this context, utilizing extensive phage-peptide libraries to identify ligands with specificity for cancer cell markers, thus enabling precision-targeted therapeutic strategies. This technology promises a paradigm shift in ovarian cancer management, concentrating on targeted drug delivery systems to improve treatment accuracy and efficacy while minimizing adverse effects. Through a meticulous review, this paper evaluates the revolutionary potential of phage display in enhancing ovarian cancer therapy, representing a significant advancement in combating this challenging disease. Phage display technology is heralded as an essential instrument for developing effective immunodiagnostic and therapeutic approaches in ovarian cancer, facilitating early detection, precision-targeted medication, and the implementation of customized treatment plans.  \nKEYWORDS  \novarian cancer, phage display technology, targeted drug delivery, immunodiagnostics, personalized therapeutic strategies  \n1 Introduction  \nOvarian cancer is identified as the seventh most common malignancy affecting women across the globe (1) . Its significance is highlighted by GLOBOCAN estimates, which report that in 2020, approximately 314,000 women were diagnosed with ovarian cancer, leading to  \n207,000 fatalities. This positions ovarian cancer as the eighth leading cause of cancerrelated incidence and mortality among women internationally (2) . Forecasts for the year 2040, based on the assumption that incidence rates remain constant at the 2020 levels, predict around 428,000 new ovarian cancer cases and 307,000 fatalities annually. Achieving  \nFrontiers in Immunology 01 [frontiersin.org](frontiersin.org)  \na 30% reduction in these figures by 2040 necessitates an annual decrease of 2% in the global incidence and mortality rates of this disease (3) . The urgent need for the development of efficacious treatments for gynecological cancers, particularly ovarian cancer, which is known as the deadliest gynecological malignancy, continues to be a significant","cbCaiceQG4ZZ8YQ5","https://ap.wps.com/l/cbCaiceQG4ZZ8YQ5","pdf",5880705,14,"English","# Introduction\n## Ovarian cancer burden and unmet clinical needs\n## Screening limitations and urgency for novel therapies","[{\"question\":\"Why is early detection of ovarian cancer difficult?\",\"answer\":\"Early detection is hampered by limitations of current screening methods, and many patients are diagnosed at late stages due to subtle, non-specific symptoms.\"},{\"question\":\"What role does phage display technology play in ovarian cancer management?\",\"answer\":\"Phage display technology uses phage–peptide libraries to identify ligands with specificity for cancer cell markers, enabling precision-targeted immunodiagnostic and therapeutic strategies.\"},{\"question\":\"How can targeted approaches improve outcomes while reducing harm?\",\"answer\":\"By focusing on targeted drug delivery systems and precision-directed therapies, the review emphasizes improved treatment accuracy and efficacy while aiming to minimize adverse effects.\"}]","Advancements in ovarian cancer immunodiagnostics and therapeutics via phage display technology - Review | PDF",1790030638,35]