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Endoscopy with histological confirmation remains the diagnostic gold standard, yet its cost, invasiveness, and need for specialized expertise limit population screening. New diagnostic approaches—including advanced imaging, liquid biopsy, and breath tests—are reshaping GC detection toward methods that are less invasive, more accessible, and clinically validated, with the goal of improving outcomes and quality of life.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/advancements-in-non-invasive-diagnosis-of-gastric-cancer/372944/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/advancements-in-non-invasive-diagnosis-of-gastric-cancer/372944.png","ImageObject",300,407,{"name":92,"@type":93},"Finn","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-03","2026-09-23",true,{"@type":102,"interactionType":103,"userInteractionCount":44},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"Why is endoscopy not ideal for widespread gastric cancer screening?","Question",{"text":112,"@type":113},"Endoscopy combined with histological examination is the gold standard, but it is costly, invasive, and requires specialized equipment and personnel, which restricts broad screening use.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What non-invasive techniques are highlighted for diagnosing gastric cancer?",{"text":117,"@type":113},"The document highlights advances in imaging, liquid biopsy, and breath tests as emerging options that can make diagnosis less invasive and more efficient.",{"name":119,"@type":110,"acceptedAnswer":120},"How does computed tomography support gastric cancer assessment?",{"text":121,"@type":113},"Computed tomography provides high spatial resolution and detailed cross-sectional images, supporting evaluation of tumor location, size, and depth of invasion.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},372944,1790897398,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":44,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":34,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144},34359740700684,"https://ap-avatar.wpscdn.com/avatar/1f400023980c374ae676?_k=1777273430885731487","| W | J | G | World Journal of\u003Cbr>Gastroenterology |\n| --- | --- | --- | --- |\n\nSubmit a Manuscript: [https://www.f6publishing.com](https://www.f6publishing.com) World J Gastroenterol 2025 February 14; 31(6): 101886  \nDOI: 10.3748/wjg.v31.i6.101886 ISSN 1007-9327 (print) ISSN 2219-2840 (online)  \n\n| Advancements in non-invasive diagnosis of gastric cancer\u003Cbr>Zhen Wang, Qi Wu | EDITORIAL |\n| --- | --- |\n\nSpecialty type: Gastroenterology and hepatology  \nProvenance and peer review:  \nInvited article; Externally peer reviewed.  \nPeer-review model: Single blind  \nPeer-review report’s classification Scientific Quality: Grade A, Grade A, Grade C, Grade C, Grade D Novelty: Grade A, Grade A, Grade C, Grade C, Grade C  \nCreativity or Innovation: Grade A, Grade A, Grade C, Grade C, Grade C  \nScientific Significance: Grade A, Grade A, Grade B, Grade C, Grade C  \nP-Reviewer: Kirkik D; Tang CL; Yakut A  \nReceived: September 29, 2024  \nRevised: December 8, 2024  \nAccepted: December 20, 2024  \nPublished online: February 14, 2025  \nProcessing time: 102 Days and 13.6 Hours  \nZhen Wang, Department of Ultrasound Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, Hubei Province, China  \nQi Wu, Department of Cardiovascular Surgery, Renmin Hospital of Wuhan University, Wuhan 430060, Hubei Province, China  \nCo-corresponding authors: Zhen Wang and Qi Wu.  \nCorresponding author: Zhen Wang, MD, PhD, Doctor, Department of Ultrasound Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, No. 1277 Jeifang Avenue, Jianghan District, Wuhan 430022, Hubei Province, China.  \n[wangzhen1993@hust.edu.cn](wangzhen1993@hust.edu.cn)  \nAbstract  \nGastric cancer (GC), a multifaceted and highly aggressive malignancy, represents challenging healthcare burdens globally, with a high incidence and mortality rate. Although endoscopy, combined with histological examination, is the gold standard for GC diagnosis, its high cost, invasiveness, and specialized requirements hinder widespread use for screening. With the emergence of innovative technologies such as advanced imaging, liquid biopsy, and breath tests, the landscape of GC diagnosis is poised for radical transformation, becoming more accessible, less invasive, and more efficient. As the non-invasive diagnostic techniques continue to advance and undergo rigorous clinical validation, they hold the promise of significantly impacting patient outcomes, ultimately leading to better treatment results and improved quality of life for patients with GC.  \nKey Words: Gastric cancer; Non-invasive; Diagnosis; Imaging; Prognosis  \n©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.  \nCore Tip: Non-invasive diagnostic methods for gastric cancer (GC) involve various techniques that minimize patient discomfort and potential complications. These approaches aim to detect early signs of the disease or identify individuals at risk for GC.  \nCitation: Wang Z, Wu Q. Advancements in non-invasive diagnosis of gastric cancer. World JGastroenterol 2025; 31(6): 101886  \nURL: [https://www.wjgnet.com/1007-9327/full/v31/i6/101886.htm](https://www.wjgnet.com/1007-9327/full/v31/i6/101886.htm)  \nDOI: [https://dx.doi.org/10.3748/wjg.v31.i6.101886](https://dx.doi.org/10.3748/wjg.v31.i6.101886)  \n WJG  [https://www.wjgnet.com](https://www.wjgnet.com) 1 February 14, 2025  Volume 31  Issue 6   \nWang Z et al. Non-invasive diagnosis of gastric cancer  \nINTRODUCTION  \nGastric cancer (GC) refers to the uncontrolled growth and proliferation of abnormal cells in the stomach lining, which can eventually invade adjacent tissues and disseminate to distant organs [1,2] . GC poses a significant global health burden, with a high incidence and mortality rate, especially in developing countries. In 2022, China reported approximately 358700 new GC cases, accounting for roughly 30%-40% of the total global incidence [3,4] . The high incide","cbCaipixNlKYsf3e","https://ap.wps.com/l/cbCaipixNlKYsf3e","pdf",407693,"English","# Introduction\n# Advanced imaging technologies\n## Computed tomography","[{\"question\":\"Why is endoscopy not ideal for widespread gastric cancer screening?\",\"answer\":\"Endoscopy combined with histological examination is the gold standard, but it is costly, invasive, and requires specialized equipment and personnel, which restricts broad screening use.\"},{\"question\":\"What non-invasive techniques are highlighted for diagnosing gastric cancer?\",\"answer\":\"The document highlights advances in imaging, liquid biopsy, and breath tests as emerging options that can make diagnosis less invasive and more efficient.\"},{\"question\":\"How does computed tomography support gastric cancer assessment?\",\"answer\":\"Computed tomography provides high spatial resolution and detailed cross-sectional images, supporting evaluation of tumor location, size, and depth of invasion.\"}]","Advancements in non-invasive diagnosis of gastric cancer | PDF",1790195923,18]