[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-380660-105":3,"detail-sidebar-cat-0-en-105":81,"doc-detail-380660-en":130},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","advancements-in-microwave-ablation-techniques-for-managing-pancreatic-lesions-review","Advancements in Microwave Ablation Techniques for Managing Pancreatic Lesions - Review","","Thermal ablation, including microwave ablation, is increasingly used to manage solid tumors, yet its adoption for pancreatic lesions has been slowed by concerns over potential adverse events. Earlier radiofrequency ablation (RFA) success in inoperable pancreatic cancers enabled use in pancreatic neuroendocrine tumors and pancreatic cystic neoplasms (PCLs). Over the last decade, microwave ablation has emerged as an alternative, using 900–2450 MHz microwaves to generate heat and achieve higher, more uniform intra-lesion temperatures. Evidence suggests promise, but limited comparative studies and concerns about peri-procedure complications support further research, especially for PCLs.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/advancements-in-microwave-ablation-techniques-for-managing-pancreatic-lesions-review/380660/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/advancements-in-microwave-ablation-techniques-for-managing-pancreatic-lesions-review/380660.png","ImageObject",300,407,{"name":42,"@type":43},"Aldword","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-11-01","2026-09-24",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",9,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"Why has microwave ablation adoption for pancreatic lesions been slower than for other solid tumors?","Question",{"text":63,"@type":64},"Concerns about potential adverse events, especially peri-procedure complications and risk of iatrogenic thermal injury to surrounding organs, delayed its use for pancreatic lesions.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"How does microwave ablation generate heat in tissue?",{"text":68,"@type":64},"Microwaves (900–2450 MHz) directed toward water molecules cause rapid oscillation, leading to frictional heat generation and resulting coagulation necrosis of the surrounding tissue.",{"name":70,"@type":61,"acceptedAnswer":71},"What advantages of microwave ablation are described compared with radiofrequency ablation (RFA)?",{"text":72,"@type":64},"Microwave ablation can reach higher intra-lesion temperatures, support more uniform heating, allow multiple antennas for broader and faster ablation, and may achieve deeper penetration due to its higher frequency.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},380660,1790273379,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,110,115,119,122,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":107,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":108,"slug":109},7,40,"healthcare",{"id":111,"doc_module":4,"doc_module_name":25,"category_name":112,"show_sort_weight":113,"slug":114},8,"Research & Report",30,"research-report",{"id":55,"doc_module":4,"doc_module_name":25,"category_name":116,"show_sort_weight":117,"slug":118},"Religion & Spirituality",20,"religion-spirituality",{"id":117,"doc_module":4,"doc_module_name":25,"category_name":120,"show_sort_weight":117,"slug":121},"World Cup","world-cup",{"id":123,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":123,"slug":125},10,"Lifestyle","lifestyle",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":97,"slug":129},19,"General","general",{"code":4,"msg":82,"data":131},{"doc_id":79,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":107,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":139,"language":140,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":12,"update_tm":144,"read_time":113},2336478940917,"https://ap-avatar.wpscdn.com/davatar_6f874abed73319feea01a86fa6f0fab8","life  \nReview  \nAdvancements in Microwave Ablation Techniques for Managing Pancreatic Lesions  \nDevarshi R. Ardeshna 1, Matthew Leupold 2, Zobeida Cruz-Monserrate 1,3, Timothy M. Pawlik 3,4, Jordan M. Cloyd 3,4, Aslam Ejaz 3,4, Hamza Shah 3, Jordan Burlen 3 and Somashekar G. Krishna 1,3, *  \nCitation: Ardeshna, D.R.; Leupold, M.; Cruz-Monserrate, Z.; Pawlik,  \nT.M.; Cloyd, J.M.; Ejaz, A.; Shah, H.; Burlen, J.; Krishna, S.G. Advancements in Microwave Ablation Techniques for Managing Pancreatic Lesions. Life 2023, 13, 2162 . [https://doi.org/10.3390/](https://doi.org/10.3390/)[ ](https://doi.org/10.3390/)life13112162  \nAcademic Editors: Doina Georgescu and Felix Bratosin  \nReceived: 27 September 2023  \nRevised: 26 October 2023  \nAccepted: 31 October 2023  \nPublished: 4 November 2023  \nCopyright: © 2023 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://](https://)[ ](https://)[creativecommons.org/licenses/by/](creativecommons.org/licenses/by/)[ ](creativecommons.org/licenses/by/)[4.0/](4.0/)) .  \n1 Division of Gastroenterology, Hepatology and Nutrition, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA  \n2 Department of Internal Medicine, Ohio State University Wexner Medical Center, Columbus, OH 43210, USA  \n3 The James Comprehensive Cancer Center, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA  \n4 Department of Surgery, The Ohio State University Wexner Medical Center, Columbus, OH 43210, USA  \n* Correspondence: [somashekar.krishna@osumc.edu](somashekar.krishna@osumc.edu)  \nAbstract: Thermal ablation, including microwave ablation, has become increasingly important in the management of many solid tumors, including primary and metastatic tumors of the liver, kidney, and lung. However, its adoption to treat pancreatic lesions has been slowed due to concerns about potential adverse events. The success of radiofrequency ablation (RFA) in inoperable pancreatic cancers paved the way for its use in pancreatic neuroendocrine tumors and pancreatic cystic neoplasms (PCLs) . In the last decade, other thermal ablation techniques, like microwave ablation, have emerged as alternatives to RFA. Microwaves, with frequencies ranging from 900 to 2450 MHz, generate heat by rapidly oscillating water molecules. Microwave ablation's advantage lies in its ability to achieve higher intra-lesion temperatures and uniform heating compared with RFA. Microwave ablation's application in pancreatic cancer and pancreatic neuroendocrine tumors has demonstrated promise with similar technical success to RFA. Yet, concern for peri-procedure complications, as well as adearth of studies comparing RFA and microwave ablation, emphasize the need for further research. No studies have evaluated microwave ablation in PCLs. We herein review thermal ablation's potential to treat pancreatic lesions.  \nKeywords: microwave ablation; thermal ablation; pancreatic cancer; neuroendocrine tumors; pancreatic cystic lesions; pancreas tumors  \n1. Introduction  \nThermal ablation is increasingly being utilized for the management of solid parenchymal tumors, such as hepatocellular cancer, renal tumors, thyroid nodules, and pulmonary tumors [1–5] . However, its application in the management of pancreas lesions was delayed due to fears of causing iatrogenic thermal injury to the surrounding organs [6] . The initial success of radiofrequency ablation (RFA) in inoperable pancreatic cancers led to its application in pancreatic neuroendocrine tumors and pancreatic cystic neoplasms (PCLs) [7–9] . Over the last decade, other techniques of thermal ablation, such as microwave ablation, high-intensity focused ultrasound, photodynamic therapy, and cryothermal ablation, have been introduced as alternatives to RFA. Amongst all modalities, microwave ablation is currently the second most common ablative technique af","cbCaihZdRrMyLERD","https://ap.wps.com/l/cbCaihZdRrMyLERD","pdf",1304277,12,"English","# Abstract\n# Introduction\n# Background","[{\"question\":\"Why has microwave ablation adoption for pancreatic lesions been slower than for other solid tumors?\",\"answer\":\"Concerns about potential adverse events, especially peri-procedure complications and risk of iatrogenic thermal injury to surrounding organs, delayed its use for pancreatic lesions.\"},{\"question\":\"How does microwave ablation generate heat in tissue?\",\"answer\":\"Microwaves (900–2450 MHz) directed toward water molecules cause rapid oscillation, leading to frictional heat generation and resulting coagulation necrosis of the surrounding tissue.\"},{\"question\":\"What advantages of microwave ablation are described compared with radiofrequency ablation (RFA)?\",\"answer\":\"Microwave ablation can reach higher intra-lesion temperatures, support more uniform heating, allow multiple antennas for broader and faster ablation, and may achieve deeper penetration due to its higher frequency.\"}]","Advancements in Microwave Ablation Techniques for Managing Pancreatic Lesions - Review | PDF",1790241193]