[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-detail-124666-en":3,"doc-seo-124666-105":30,"detail-sidebar-cat-0-en-105":91},{"code":4,"msg":5,"data":6},0,"success",{"doc_id":7,"user_id":8,"nickname":9,"user_avatar":10,"doc_module":4,"category_id":11,"category_name":12,"doc_title":13,"doc_description":14,"doc_content":15,"file_id":16,"file_url":17,"file_type":18,"file_size":19,"view_count":4,"is_deleted":4,"is_public":20,"is_downloadable":20,"audit_status":20,"page_count":21,"language":22,"language_code":23,"site_id":24,"html_lang":23,"table_of_contents":25,"faqs":26,"seo_title":27,"seo_description":14,"update_tm":28,"read_time":29},124666,962075006959,"Anda","https://ap-avatar.wpscdn.com/avatar/e0002397efbe92a78e?_k=1776741047341049297",8,"Research & Report","Advancements in Hemodynamic Measurement - Arterial Resonance, Ultrasound, and Machine Learning","This thesis presents two distinct research projects that use ultrasound to measure blood pressure through different approaches. The first project develops and validates a noninvasive, continuous, calibration-free method based on arterial resonance, including a first-principles physical model, in vitro validation, and in vivo testing on 60 subjects. Results show robust resonance detection and accurate blood pressure calculation for most participants. The second project applies machine learning to estimate right atrial pressure from cardiologists’ assessments, with evaluation against invasive catheter gold-standard measurements.","Advancements in Hemodynamic Measurement: Arterial Resonance, Ultrasound, and Machine Learning  \nThesis by  \nDominic Yurk  \nIn Partial Fulfillment of the Requirements for the Degree of  \nDoctor of Philosophy  \nCALIFORNIA INSTITUTE OF TECHNOLOGY Pasadena, California  \n2023  \nDefended May 31, 2023  \nii  \n© 2023  \nDominic Yurk ORCID: 0000-0002-2276-4189  \nAll rights reserved  \niii  \nACKNOWLEDGEMENTS  \nThroughout my education I have been fortunate to receive education, mentorship, and support from a long line of people who have helped me reach where I am today. Beginning in middle and high school, teachers such as Richard Bouton, Ron Boley, Andrew Brinker, Gary Hicks, Dr. Brett Stewart, and Dr. Chuck Riedel built up my scientific curiosity and helped me push beyond standard curricula to explore new areas. While I had plans to be a physics major I was encouraged to spread my studies to many other topics, most importantly math, biology, and computer science. When I began my undergraduate education at Caltech I was selected for the Ph 11 research program by Dr. Tom Tombrello, and while I didn’t realize it at the time this largely ended up setting the course of my scientific career. Tom was a big proponent of cross-disciplinary thinking, and he encouraged me to think laterally in my research as well. Through Ph 11 I was paired for a summer research project with Dr. Aditya Rajagopal, who was using information theory and physics to improve PCR diagnostics. That project started me on the path of biomedical research from nontraditional angles; I’ve continued to follow that path through my thesis and intend to continue following it for my career.  \nMy thesis research relied on help from many people, beginning with Aditya and my faculty advisor Dr. Yaser Abu-Mostafa. Between them they guided and supported my research efforts in ultrasound and blood pressure by providing advice, securing funding, and connecting me with a range of essential collaborators. In my first project I relied on help from the team at Esperto Medical, in particular Raymond Jimenez, who constructed all of the hardware necessary to test CARDI-BP, and Dr. Alaina Rajagopal, who provided medical guidance and was the driving force behind the clinical study. Further collaboration with Steven Dell, Dr. Bill Dempsey, Austin Rutledge, and Dr. Matt Fu helped to round out the project and got the CARDI-BP concept from an idea on paper to a successful clinical test at a rapid pace. This project was supported at various stages by funding from Charlie Trimble, the Carver Mead Innovation Fund, the Grubstake Grant, and Maverick Capital, and scientific illustrations were created by Laura Gleason. The second project could not have happened at all without the UCSF collaboration, initially facilitated by Dr. Dan Schwartz. In addition to providing me with data, Drs. Arun Padmanabhan and Geoff Tison from UCSF Cardiology both contributed significant time to helping me understand the physiology and medical implications of right atrial pressure and the  \niv  \nsniff test. Dr. Joshua Barrios also provided significant help with orienting me to the dataset and showing me how to interact with and manipulate it, saving me countless hours of muddling through it myself. This project was supported by the Merkin Institute for Translational research through an Innovation Seed Grant.  \nI am also happy to be able to thank all of my personal supporters who have helped carry me through this journey. My parents have always been an incredible support system, consistently advocating for me and always finding new opportunities to broaden my horizons for both education and the fun parts of life outside of it. My sister Emily has a scientific mind as well but also an incredible artistic ability, and she helps me keep my mind on the world beyond science. The many friends I’ve made during my time in grad school also made sure that I remembered to have fun and get outside of the Caltech bubble. By far my biggest support","cbCaikjweCkDdZuT","https://ap.wps.com/l/cbCaikjweCkDdZuT","pdf",16002622,1,162,"English","en",105,"# Acknowledgements\n# Abstract\n# Thesis Overview\n## Project 1: Arterial Resonance-Based Continuous Measurement\n## Project 2: Machine Learning for Right Atrial Pressure","[{\"question\":\"What two ultrasound-based blood pressure measurement projects does the thesis cover?\",\"answer\":\"The thesis covers one approach using arterial resonance to estimate continuous arterial blood pressure and a second approach using machine learning to model right atrial pressure assessments.\"},{\"question\":\"How does the first project achieve continuous, calibration-free measurement?\",\"answer\":\"It derives a resonance-based physical model and validates it in vitro, then tests it in vivo to enable continuous blood pressure calculation without calibration.\"},{\"question\":\"How is the second project evaluated and benchmarked?\",\"answer\":\"Model predictions for right atrial pressure are compared against invasive catheter measurements, described as gold standard, to assess statistical similarity.\"}]","Advancements in Hemodynamic Measurement - Arterial Resonance, Ultrasound, and Machine Learning | PDF",1785893752,408,{"code":4,"msg":31,"data":32},"ok",{"site_id":24,"language":23,"slug":33,"title":13,"keywords":34,"description":14,"schema_data":35,"social_meta":86,"head_meta":88,"extra_data":90,"updated_unix":28},"advancements-in-hemodynamic-measurement-arterial-resonance-ultrasound-and-machine-learning","",{"@graph":36,"@context":85},[37,54,68],{"@type":38,"itemListElement":39},"BreadcrumbList",[40,44,48,51],{"item":41,"name":42,"@type":43,"position":20},"https://docshare.wps.com","Home","ListItem",{"item":45,"name":46,"@type":43,"position":47},"https://docshare.wps.com/document/","Document",2,{"item":49,"name":12,"@type":43,"position":50},"https://docshare.wps.com/document/research-report/",3,{"item":52,"name":13,"@type":43,"position":53},"https://docshare.wps.com/document/advancements-in-hemodynamic-measurement-arterial-resonance-ultrasound-and-machine-learning/124666/",4,{"url":52,"name":13,"@type":55,"author":56,"headline":13,"publisher":58,"fileFormat":61,"inLanguage":23,"description":14,"dateModified":62,"datePublished":62,"encodingFormat":61,"isAccessibleForFree":63,"interactionStatistic":64},"DigitalDocument",{"name":9,"@type":57},"Person",{"url":41,"name":59,"@type":60},"DocShare","Organization","application/pdf","2026-08-05",true,{"@type":65,"interactionType":66,"userInteractionCount":4},"InteractionCounter",{"@type":67},"ViewAction",{"@type":69,"mainEntity":70},"FAQPage",[71,77,81],{"name":72,"@type":73,"acceptedAnswer":74},"What two ultrasound-based blood pressure measurement projects does the thesis cover?","Question",{"text":75,"@type":76},"The thesis covers one approach using arterial resonance to estimate continuous arterial blood pressure and a second approach using machine learning to model right atrial pressure assessments.","Answer",{"name":78,"@type":73,"acceptedAnswer":79},"How does the first project achieve continuous, calibration-free measurement?",{"text":80,"@type":76},"It derives a resonance-based physical model and validates it in vitro, then tests it in vivo to enable continuous blood pressure calculation without calibration.",{"name":82,"@type":73,"acceptedAnswer":83},"How is the second project evaluated and benchmarked?",{"text":84,"@type":76},"Model predictions for right atrial pressure are compared against invasive catheter measurements, described as gold standard, to assess statistical similarity.","https://schema.org",{"og:url":52,"og:type":87,"og:title":13,"og:site_name":59,"og:description":14},"article",{"robots":89,"canonical":52},"index,follow",{"doc_id":7,"site_id":24},{"code":4,"msg":5,"data":92},[93,97,101,105,110,115,120,123,128,131,135],{"id":20,"doc_module":4,"doc_module_name":46,"category_name":94,"show_sort_weight":95,"slug":96},"Story & Novel",90,"story-novel",{"id":47,"doc_module":4,"doc_module_name":46,"category_name":98,"show_sort_weight":99,"slug":100},"Literature",80,"literature",{"id":53,"doc_module":4,"doc_module_name":46,"category_name":102,"show_sort_weight":103,"slug":104},"Exam",70,"exam",{"id":106,"doc_module":4,"doc_module_name":46,"category_name":107,"show_sort_weight":108,"slug":109},5,"Comic",60,"comic",{"id":111,"doc_module":4,"doc_module_name":46,"category_name":112,"show_sort_weight":113,"slug":114},6,"Technology",50,"technology",{"id":116,"doc_module":4,"doc_module_name":46,"category_name":117,"show_sort_weight":118,"slug":119},7,"Healthcare",40,"healthcare",{"id":11,"doc_module":4,"doc_module_name":46,"category_name":12,"show_sort_weight":121,"slug":122},30,"research-report",{"id":124,"doc_module":4,"doc_module_name":46,"category_name":125,"show_sort_weight":126,"slug":127},9,"Religion & Spirituality",20,"religion-spirituality",{"id":126,"doc_module":4,"doc_module_name":46,"category_name":129,"show_sort_weight":126,"slug":130},"World Cup","world-cup",{"id":132,"doc_module":4,"doc_module_name":46,"category_name":133,"show_sort_weight":132,"slug":134},10,"Lifestyle","lifestyle",{"id":136,"doc_module":4,"doc_module_name":46,"category_name":137,"show_sort_weight":106,"slug":138},19,"General","general"]