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The review emphasizes the need for novel therapeutic compounds with improved clinical features and highlights a broad range of advanced modalities, including endocrine therapy, chemotherapy, radiation therapy, antimicrobial peptide-dependent approaches, liposome delivery, photothermal therapy, immunotherapy, and nano drug delivery systems. Silk sericin and sericin-conjugated nanoparticles are presented as promising anticancer biomedical agents with suitable biocompatible properties.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/advanced-treatment-strategies-in-breast-cancer-a-comprehensive-mechanistic-review/378135/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/advanced-treatment-strategies-in-breast-cancer-a-comprehensive-mechanistic-review/378135.png","ImageObject",300,407,{"name":92,"@type":93},"วิน","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-30","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":44},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"Why are advanced-stage breast cancers difficult to treat?","Question",{"text":112,"@type":113},"Advanced stages of breast cancer are challenging to manage even with multi-directional therapeutic strategies, leading to substantial healthcare burdens.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Which advanced treatment approaches are discussed in the review?",{"text":117,"@type":113},"The review covers endocrine therapy, chemotherapy, radiation therapy, antimicrobial peptide-dependent growth inhibitor strategies, liposome-based delivery, antibiotics as co-medication, photothermal therapy, immunotherapy, and nano drug delivery systems.",{"name":119,"@type":110,"acceptedAnswer":120},"What is the proposed role of silk sericin in nano drug delivery?",{"text":121,"@type":113},"Silk sericin and sericin-conjugated nanoparticles are described as biocompatible candidates with restricted breakdown properties, making them suitable for nanoscale drug-delivery systems and anticancer testing in pre-clinical settings.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},378135,1790371822,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":44,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},2336475104736,"https://ap-avatar.wpscdn.com/avatar/22000c4c5e0e5b17e70?x-image-process=image/resize,m_fixed,w_180,h_180&k=1786591360781797222","Review SCIENCE PROGRESS  \nAdvanced treatment strategies in breast cancer: A comprehensive mechanistic review  \nSamaira Mumtaz 1, Shaukat Ali 1 , Shumaila Mumtaz 1, Asim Pervaiz2, Hafiz M Tahir1, Muhammad A Farooq 1 and Tafail A Mughal 1  \n1 Medical Toxicology and Entomology Laboratory, Department of Zoology, Government College University, Lahore, Pakistan 2Biomedical and Allied Health Sciences, University of Health Sciences Lahore, Lahore, Pakistan  \nScience Progress 2023, Vol. 106(2) 1–32 © The Author(s) 2023 Article reuse guidelines:  \n[sagepub.com/journals-permissions](sagepub.com/journals-permissions)[ ](sagepub.com/journals-permissions)[DOI: 10.1177/00368504231175331](DOI: 10.1177/00368504231175331)[ ](DOI: 10.1177/00368504231175331)[journals.sagepub.com/home/sci](journals.sagepub.com/home/sci)  \nAbstract  \nBreast cancer is a destructive lump type that affects women globally. Despite the availability of multi-directional therapeutic strategies, advanced stages of breast cancer are difficult to treat and impose major healthcare burdens. This situation reinforces the need to identify new potential therapeutic compounds with better clinical features. In this context, different treatment methods were included such as Endocrine therapy, chemotherapy, Radiation therapy, antimicrobial peptidedependent growth inhibitor, liposome-based drug delivery, antibiotics used as a co-medication, photothermal, immunotherapy, and nano drug delivery systems such as Bombyx mori natural protein sericin and its mediated nanoparticles are promising biomedical agents. They have been tested as an anticancer agent against various malignancies in pre-clinical settings. The biocompatible and restricted breakdown properties of silk sericin and sericin-conjugated nanoparticles made them perfect contenders for a nanoscale drug-delivery system.  \nKeywords  \nBreast cancer, prognosis, molecular subtypes, sericin, breast malignancy growth pattern  \nCorresponding author:  \nShaukat Ali, Medical Toxicology and Entomology Laboratory, Department of Zoology, Government College University, Lahore, Pakistan.  \nEmail: [dr.shaukatali@gcu.edu.pk](dr.shaukatali@gcu.edu.pk)  \nCreative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative  \nCommons Attribution-NonCommercial 4.0 License ([https://creativecommons.org/licenses/by-nc/4.0/](https://creativecommons.org/licenses/by-nc/4.0/)) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access page ([https://us.sagepub.com/en-us/nam/open-access-at-sage](https://us.sagepub.com/en-us/nam/open-access-at-sage)).  \nIntroduction  \nWorldwide, cancer is the foremost source of human fatality and a chief community fitness apprehension. Generally, during various years, it can be defined as any part of the body having an unrestrained expansion and proliferation of the cells occurring due to genetic alterations and harmful environmental factors. In the case of cancer, during the transformation process, important genes like a tumor suppressor and oncogene deregulate and this imbalance leads to lethal cellular changes.1 Breast cancers (BCs) are widespread and destructive tumor types that affect the female population in the entire world.1  \nThis review is very important for every human being globally. Cancer, BC, and treatment strategies with a natural product are very significant. This review is intended for everyone.  \nTaxonomy of breast malignancy  \nBreast tumors physiology changes according to the stage, a grade of the patient-oriented characteristics.2,3 Breast tumors can be largely divided into two main kinds which include invasive (infiltrating) carcinoma and in situ ductal carcinoma.4 In situ breast carcinoma is additionally subdivided as either lobular cancer in situ or DC in situ. Lobular cancer in situ commences as of unusual lobular hyperplasia and ductal carcinoma in sit","cbCaibMLfGj8Bw8T","https://ap.wps.com/l/cbCaibMLfGj8Bw8T","pdf",2529650,32,"English","# Abstract\n# Introduction\n# Taxonomy of breast malignancy\n# Breast malignancy growth pattern","[{\"question\":\"Why are advanced-stage breast cancers difficult to treat?\",\"answer\":\"Advanced stages of breast cancer are challenging to manage even with multi-directional therapeutic strategies, leading to substantial healthcare burdens.\"},{\"question\":\"Which advanced treatment approaches are discussed in the review?\",\"answer\":\"The review covers endocrine therapy, chemotherapy, radiation therapy, antimicrobial peptide-dependent growth inhibitor strategies, liposome-based delivery, antibiotics as co-medication, photothermal therapy, immunotherapy, and nano drug delivery systems.\"},{\"question\":\"What is the proposed role of silk sericin in nano drug delivery?\",\"answer\":\"Silk sericin and sericin-conjugated nanoparticles are described as biocompatible candidates with restricted breakdown properties, making them suitable for nanoscale drug-delivery systems and anticancer testing in pre-clinical settings.\"}]","Advanced treatment strategies in breast cancer - A comprehensive mechanistic review | PDF",1790228618,81]