[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-330234-105":59,"doc-detail-330234-en":131},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":124,"head_meta":126,"extra_data":128,"updated_unix":130},105,"en","advanced-diagnostic-and-therapeutic-endoscopy-for-early-gastric-cancer","Advanced Diagnostic and Therapeutic Endoscopy for Early Gastric Cancer","","Endoscopy is essential for detecting early gastric cancer (EGC). For cost-effective screening, risk stratification combining serum pepsinogen levels and anti-Helicobacter pylori (H. pylori) IgG antibody values shows strong promise. After suspicious lesions are identified, magnifying endoscopy with band-limited light is needed to reveal cancer-specific irregular microsurface and microvascular patterns with demarcation lines. Endocytoscopy supports in vivo histological diagnosis, while absolute, expanded, and relative indications guide endoscopic resection and evaluate lymph node metastasis risk and en bloc feasibility.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/advanced-diagnostic-and-therapeutic-endoscopy-for-early-gastric-cancer/330234/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/advanced-diagnostic-and-therapeutic-endoscopy-for-early-gastric-cancer/330234.png","ImageObject",300,407,{"name":92,"@type":93},"Anda","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-29","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",12,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"Why is endoscopy mandatory in early gastric cancer detection?","Question",{"text":113,"@type":114},"Endoscopy is required to detect early gastric cancer. The article emphasizes that timely identification depends on endoscopic evaluation rather than relying solely on other screening approaches.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"How does the review propose to improve cost-effectiveness in EGC screening?",{"text":118,"@type":114},"It recommends risk stratification by combining serum pepsinogen values with anti-H. pylori IgG antibody values. This approach aims to better target individuals at higher risk.",{"name":120,"@type":111,"acceptedAnswer":121},"What endoscopic methods are highlighted for diagnosis and treatment decisions?",{"text":122,"@type":114},"Magnifying endoscopy with band-limited light (e.g., narrow-band imaging) is described for identifying suspicious cancer patterns, and endocytoscopy is mentioned for in vivo histological diagnosis. For treatment, endoscopic mucosal resection and endoscopic submucosal dissection are the main modalities, with indications divided into absolute, expanded, and relative categories.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},330234,1790062863,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":105,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":41},962075006959,"https://ap-avatar.wpscdn.com/avatar/e0002397efbe92a78e?_k=1776741047341049297","cancers   \nReview  \nAdvanced Diagnostic and Therapeutic Endoscopy for Early Gastric Cancer  \nMitsuhiro Fujishiro   \nCitation: Fujishiro, M. Advanced Diagnostic and Therapeutic Endoscopy for Early Gastric Cancer. Cancers 2024, 16, 1039. [https://](https://)[ ](https://)[doi.org/10.3390/cancers16051039](doi.org/10.3390/cancers16051039)  \nAcademic Editor: Alain P. Gobert  \nReceived: 8 February 2024  \nRevised: 1 March 2024  \nAccepted: 1 March 2024  \nPublished: 3 March 2024  \nCopyright: © 2024 by the author. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://](https://)[ ](https://)[creativecommons.org/licenses/by/](creativecommons.org/licenses/by/)[ ](creativecommons.org/licenses/by/)[4.0/](4.0/)) .  \nDepartment of Gastroenterology, Graduate School of Medicine, The University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo 113-8655, Japan; [mtfujish@gmail.com](mtfujish@gmail.com); Tel.: +81-3-3815-5411; Fax: +81-3-5800-8799  \nSimple Summary: Advances in gastric cancer screening and endoscopic technology have made it possible to detect and treat gastric cancer at an early stage. As a result, about 40% of all gastric cancers have now been resected via endoscopic treatment in Japan. In endoscopic diagnosis, magnifying endoscopic observation using band-limited light such as narrow-band imaging (NBI) has significantly improved the accuracy of gastric cancer diagnosis. At the same time, in endoscopic treatment, endoscopic submucosal dissection (ESD) has contributed to notably increasing the number of gastric cancers that can be resected endoscopically. In recent years, the construction of algorithms for endoscopic diagnosis and treatment with a view to personalized medicine has been explored, and the use of endoscopy for gastric cancer management is expected to develop further in the future.  \nAbstract: Endoscopy is mandatory to detect early gastric cancer (EGC) . When considering the costeffectiveness of the endoscopic screening of EGC, risk stratification by combining serum pepsinogen values and anti-H. pylori IgG antibody values is very promising. After the detection of suspicious lesions of EGC, a detailed observation using magnifying endoscopy with band-limited light is necessary, which reveals an irregular microsurface and/or an irregular microvascular pattern with demarcation lines in the case of cancerous lesions. Endocytoscopy enables us to make an in vivo histological diagnosis. In terms of the indications for endoscopic resection, the likelihood of lymph node metastasis and technical difficulties in en bloc resection is considered, and they are divided into absolute, expanded, and relative indications. Endoscopic mucosal resection and endoscopic submucosal dissection are the main treatment modalities nowadays. After endoscopic resection, curability is evaluated histologically as endoscopic curability (eCura) A, B, and C (C-1 and C-2) . Recent evidence suggests that the outcomes of endoscopic resection for many EGCs are comparable to those of gastrectomy and that endoscopic resection is the gold standard for node-negative early gastric cancers. Personalized medicine is also being developed to overcome the unmet needs in treatments of EGC, for example the further expansion of indications and newer resection techniques, such as full-thickness resection.  \nKeywords: early gastric cancer; gastric cancer screening; endoscopic diagnosis; endoscopic mucosal resection; endoscopic submucosal dissection  \n1. Introduction  \nAlthough the number of patients with gastric cancer is expected to decrease in the future due to the decline in the number of people infected with Helicobacter pylori (H. pylori) and the spread of H. pylori eradication therapy, the incidence of gastric cancer still ranks fifth among all cancer types (1,089,103), and it caused the fourth largest number of deaths (768,793) in 2020 in the world [1] . W","cbCaikUI2yYQpy4N","https://ap.wps.com/l/cbCaikUI2yYQpy4N","pdf",16987936,"English","# Simple Summary\n# Abstract\n# Keywords\n# 1. Introduction\n# 2. The Role of Endoscopy in Gastric Cancer Detection","[{\"question\":\"Why is endoscopy mandatory in early gastric cancer detection?\",\"answer\":\"Endoscopy is required to detect early gastric cancer. The article emphasizes that timely identification depends on endoscopic evaluation rather than relying solely on other screening approaches.\"},{\"question\":\"How does the review propose to improve cost-effectiveness in EGC screening?\",\"answer\":\"It recommends risk stratification by combining serum pepsinogen values with anti-H. pylori IgG antibody values. This approach aims to better target individuals at higher risk.\"},{\"question\":\"What endoscopic methods are highlighted for diagnosis and treatment decisions?\",\"answer\":\"Magnifying endoscopy with band-limited light (e.g., narrow-band imaging) is described for identifying suspicious cancer patterns, and endocytoscopy is mentioned for in vivo histological diagnosis. For treatment, endoscopic mucosal resection and endoscopic submucosal dissection are the main modalities, with indications divided into absolute, expanded, and relative categories.\"}]","Advanced Diagnostic and Therapeutic Endoscopy for Early Gastric Cancer | PDF",1789987831]