[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-353967-105":59,"doc-detail-353967-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","adolescent-renal-tumours-diagnostic-and-therapeutic-challenges-in-a-transitional-age-group-a-multidisciplinary-case-report-series-from-a-single-center","Adolescent Renal Tumours: Diagnostic and Therapeutic Challenges in a Transitional Age Group - A Multidisciplinary Case Report Series from a Single Center","","Management of renal neoplasms in adolescent patients presents distinctive clinical difficulties because this population transitions between paediatric and adult oncology care. The tumour spectrum shows broad histological heterogeneity, spanning typical paediatric entities, adult-like renal tumours, and rare subtypes that involve the kidney. Marked differences in paediatric and adult clinical protocols require rigorous multidisciplinary assessment to select diagnostic and therapeutic strategies. A single-centre series of four cases illustrates variability in imaging, pathology, outcomes, and the need for comprehensive integrated management.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/adolescent-renal-tumours-diagnostic-and-therapeutic-challenges-in-a-transitional-age-group-a-multidisciplinary-case-report-series-from-a-single-center/353967/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/adolescent-renal-tumours-diagnostic-and-therapeutic-challenges-in-a-transitional-age-group-a-multidisciplinary-case-report-series-from-a-single-center/353967.png","ImageObject",300,407,{"name":92,"@type":93},"WPS_1786070896","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-09-23","2026-09-22",true,{"@type":102,"interactionType":103,"userInteractionCount":8},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"Why are diagnostic and therapeutic decisions challenging for adolescent renal tumours?","Question",{"text":112,"@type":113},"Adolescents sit between paediatric and adult oncology, leading to marked differences in tumour histology and clinical protocols. Rigorous multidisciplinary evaluation is needed to choose optimal diagnostic and treatment strategies.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How does the document describe differences in tumour histology by age?",{"text":117,"@type":113},"European data show Wilms’ tumour predominates in younger children, while renal cell carcinoma becomes increasingly common by mid-adolescence, with different subtype distributions in adults.",{"name":119,"@type":110,"acceptedAnswer":120},"What imaging and diagnostic steps are highlighted for suspected renal neoplasia?",{"text":121,"@type":113},"Initial imaging is described as similar across age groups, using renal ultrasonography followed by abdominal MRI (or CT when MRI is unavailable), plus thoracic CT and reference chest radiography for metastatic assessment and follow-up comparisons.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},353967,1790143795,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":8,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":36},549768072016,"https://ap-avatar.wpscdn.com/davatar_155a257f0dc6eb9ab79c44ca47cae57d","Tech Science Press  \n| [https://doi. org/10.32604/or.2026.072807](https://doi. org/10.32604/or.2026.072807)\u003Cbr>CASE REPORT | \u003Cbr>|\n| --- | --- |\n| Adolescent Renal Tumours: Diagnostic and Therapeutic Challenges in a Transitional Age Group—A Multidisciplinary Case Report Series from a Single Center\u003Cbr>Antonio Ruggiero1,2, *, Fernando Fuccillo1, Valerio Di Paola3, Alberto Romano1, Palma Maurizi1,2, Dario Talloa1, Nazario Foschi4, Pierluigi Russo4, Marco Racioppi4, Stefano Mastrangelo1,2 and Giorgio Attinà1\u003Cbr>1 Pediatric Oncology Unit, Fondazione Policlinico Universitario Agostino Gemelli IRCCS, Rome, Italy\u003Cbr>2 Department of Woman and Child Health and Public Health, Università Cattolica del Sacro Cuore, Rome, Italy\u003Cbr>3 Department of Bioimaging, Radiation Oncology and Hematology, Fondazione Policlinico Universitario A. Gemelli IRCSS, Rome, Italy\u003Cbr>4 Department of Urology, Fondazione Policlinico Universitario Agostino Gemelli, Rome, Italy\u003Cbr>*Corresponding Author: Antonio Ruggiero. Email: [antonio.ruggiero@unicatt.it](antonio.ruggiero@unicatt.it)[ ](antonio.ruggiero@unicatt.it)[Received: 04 September 2025](Received: 04 September 2025); [Accepted: 20 January 2026](Accepted: 20 January 2026); [Published: 23 March 2026](Published: 23 March 2026)\u003Cbr>ABSTRACT: Background: The management of renal neoplasms in adolescent patients poses unique clinical challenges due to their transitional position between paediatric and adult populations. This age group exhibits marked heterogeneity in tumour histology, ranging from entities commonly observed in paediatric oncology to tumours typical of adult age, as well as rare histological subtypes that exceptionally affect the kidney. Given the substantial differences in clinical protocols between paediatric and adult populations, rigorous multidisciplinary evaluation is essential to determine optimal diagnostic and therapeutic strategies for adolescent patients. Case Description: We present four cases from our tertiary referral centre that illustrate the variability in radiological and histopathological presentations and clinical outcomes in this population, underscoring the critical importance of a multidisciplinary approach. Case 1 demonstrates the typical management of Wilms’ tumour in an older paediatric patient. Case 2 exemplifies the diagnostic challenge of distinguishing between Wilms’ tumour and renal cell carcinoma at the upper end of the adolescent spectrum. Case 3 revealed the unexpected diagnosis of renal Ewing sarcoma in a 13-year-old female. Case 4 highlights the potential for severe perioperative complications, including life-threatening thromboembolic events, in a patient with Wilms’ tumour. Conclusions: The variability in tumour types, biological behaviour, and potential for severe complications underscores the necessity of comprehensive multidisciplinary management in specialized hospital settings. An integrated approach ensures accurate diagnosis, individualized treatment planning, and effective management of complications, ultimately optimizing outcomes for adolescent patients with renal neoplasms.\u003Cbr>KEYWORDS: Paediatric oncology; adolescent oncology; renal tumours; Wilms’ tumour (WT); renal cell carcinoma (RCC); case report |  |\n\n1 Introduction  \nEpidemiological data from Europe indicate that renal tumours constitute approximately 7% of paediatric malignancies, with Wilms’ tumour (WT) representing the predominant histological subtype (90%) . The annual incidence of WT is approximately 1 in 100,000 children, with peak incidence at approximately 3 years of age. Less common paediatric renal tumour histological subtypes include clear cell sarcoma of  \nCopyright © 2026 The Authors. Published by Tech Science Press. This work is licensed under a Creative Commons Attribution 4.0 International License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.  \nthe kidney (CCSK), malignant rhabdoid tumour of the kidney ","cbCaieGgqfoOWLyn","https://ap.wps.com/l/cbCaieGgqfoOWLyn","pdf",12400203,16,"English","# Introduction\n## Epidemiology and age-related histology\n## Diagnostic workflow and imaging\n## Biopsy indications and uncertainty","[{\"question\":\"Why are diagnostic and therapeutic decisions challenging for adolescent renal tumours?\",\"answer\":\"Adolescents sit between paediatric and adult oncology, leading to marked differences in tumour histology and clinical protocols. Rigorous multidisciplinary evaluation is needed to choose optimal diagnostic and treatment strategies.\"},{\"question\":\"How does the document describe differences in tumour histology by age?\",\"answer\":\"European data show Wilms’ tumour predominates in younger children, while renal cell carcinoma becomes increasingly common by mid-adolescence, with different subtype distributions in adults.\"},{\"question\":\"What imaging and diagnostic steps are highlighted for suspected renal neoplasia?\",\"answer\":\"Initial imaging is described as similar across age groups, using renal ultrasonography followed by abdominal MRI (or CT when MRI is unavailable), plus thoracic CT and reference chest radiography for metastatic assessment and follow-up comparisons.\"}]","Adolescent Renal Tumours: Diagnostic and Therapeutic Challenges in a Transitional Age Group - A Multidisciplinary Case Report Series from a Single Center | PDF",1790108223]