[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-331017-105":59,"doc-detail-331017-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","adjuvant-properties-of-caffeic-acid-in-cancer-treatment","Adjuvant Properties of Caffeic Acid in Cancer Treatment","","Caffeic acid (CA), a plant polyphenol of the phenylpropanoid family, is reviewed as a promising adjunct in cancer treatment. The review summarizes CA’s discovery and biosynthesis, then links its actions to antioxidant, anti-inflammatory, and anticancer effects mediated by pathway modulation, including suppression of NF-κB, STAT3, and ERK1/2 and activation of the Nrf2/ARE axis. Evidence further discusses reduced cancer risk, alleviation of chemotherapy/radiotherapy toxicity, and reversal of chemoresistance, with generally favorable safety.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/adjuvant-properties-of-caffeic-acid-in-cancer-treatment/331017/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/adjuvant-properties-of-caffeic-acid-in-cancer-treatment/331017.png","ImageObject",300,407,{"name":92,"@type":93},"Liam","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-30","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":34},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is caffeic acid and where is it commonly found?","Question",{"text":112,"@type":113},"Caffeic acid is a naturally occurring polyphenol found widely in plants, notably in beverages such as coffee and yerba mate. It belongs to the phenylpropanoid family.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How does caffeic acid exert antioxidant effects relevant to cancer?",{"text":117,"@type":113},"CA mitigates harmful reactive oxygen species that threaten DNA, proteins, and lipids, acting as a primary antioxidant. It also stimulates the Nrf2/ARE pathway to enhance intracellular antioxidant defenses.",{"name":119,"@type":110,"acceptedAnswer":120},"What cancer-treatment adjunct benefits does the review highlight?",{"text":121,"@type":113},"The review links CA consumption to reduced risk of certain cancers, mitigation of chemotherapy and radiotherapy-induced toxicity, and reversal of resistance to first-line chemotherapeutic agents. It also notes that CA is generally safe with limited adverse effects reported.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},331017,1790917626,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":34,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145,"preview_page_count":4},8796095461564,"https://ap-avatar.wpscdn.com/davatar_155a257f0dc6eb9ab79c44ca47cae57d","Review  \nAdjuvant Properties of Caffeic Acid in Cancer Treatment  \nNicole Cortez 1, Cecilia Villegas 1, Viviana Burgos 2, Jaime R. Cabrera-Pardo 3, Leandro Ortiz 4, Iván González-Chavarría 5, Vaderament-A. Nchiozem-Ngnitedem 6 and Cristian Paz 1, *  \nCitation: Cortez, N.; Villegas, C.; Burgos, V.; Cabrera-Pardo, J.R.; Ortiz, L.; González-Chavarría, I.;  \nNchiozem-Ngnitedem, V.-A.; Paz, C. Adjuvant Properties of Caffeic Acid in Cancer Treatment. Int. J. Mol. Sci. 2024, 25, 7631. [https://doi.org/](https://doi.org/)[ ](https://doi.org/)[10.3390/ijms25147631](10.3390/ijms25147631)  \nAcademic Editor: Diamanto Lazari  \nReceived: 27 May 2024  \nRevised: 4 July 2024  \nAccepted: 8 July 2024  \nPublished: 11 July 2024  \nCopyright: © 2024 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license ([https://](https://)[ ](https://)[creativecommons.org/licenses/by/](creativecommons.org/licenses/by/)[ ](creativecommons.org/licenses/by/)[4.0/](4.0/)) .  \n1 Laboratory of Natural Products & Drug Discovery, Center CEBIM, Department of Basic Sciences, Faculty of Medicine, Universidad de La Frontera, Temuco 4780000, Chile; [n.cortezsalvo01@gmail.com](n.cortezsalvo01@gmail.com) (N.C.); [c.villegas04@ufromail.cl](c.villegas04@ufromail.cl) (C.V.)  \n2 Departamento de Ciencias Biológicas y Químicas, Facultad de Recursos Naturales, Universidad Católica de Temuco, Rudecindo Ortega, Temuco 4780000, Chile; [vburgos@uct.cl](vburgos@uct.cl)  \n3 Laboratorio de Química Aplicada y Sustentable (LabQAS), Departamento de Química, Facultad de Ciencias, Universidad del Bío-Bío, Concepción 4081112, Chile; [jacabrera@ubiobio.cl](jacabrera@ubiobio.cl)  \n4 Instituto de Ciencias Químicas, Facultad de Ciencias, Universidad Austral de Chile, Valdivia 5110566, Chile; [leandro.ortiz@uach.cl](leandro.ortiz@uach.cl)  \n5 Departamento de Fisiopatología, Facultad de Ciencias Biológicas Universidad de Concepción, Concepción 4030000, Chile; [ivangonzalez@udec.cl](ivangonzalez@udec.cl)  \n6 Institut für Chemie, Universität Potsdam, D-14476 Potsdam, Germany; nchiozem-ngnitedem@uni-potsdam.de  \n* Correspondence: [cristian.paz@ufrontera.cl](cristian.paz@ufrontera.cl); Tel.: +56-(45)-2592825  \nAbstract: Caffeic acid (CA) is a polyphenol belonging to the phenylpropanoid family, commonly found in plants and vegetables. It was first identified by Hlasiwetz in 1867 as a breakdown product of caffetannic acid. CA is biosynthesized from the amino acids tyrosine or phenylalanine through specific enzyme-catalyzed reactions. Extensive research since its discovery has revealed various health benefits associated with CA, including its antioxidant, anti-inflammatory, and anticancer properties. These effects are attributed to its ability to modulate several pathways, such as inhibiting NFkB, STAT3, and ERK1/2, thereby reducing inflammatory responses, and activating the Nrf2/ARE pathway to enhance antioxidant cell defenses. The consumption of CA has been linked to a reduced risk of certain cancers, mitigation of chemotherapy and radiotherapy-induced toxicity, and reversal of resistance to first-line chemotherapeutic agents. This suggests that CA could serve as a useful adjunct in cancer treatment. Studies have shown CA to be generally safe, with few adverse effects (such as back pain and headaches) reported. This review collates the latest information from Google Scholar, PubMed, the Phenol-Explorer database, [and ClinicalTrials.gov](and ClinicalTrials.gov), incorporating a total of 154 articles, to underscore the potential of CA in cancer prevention and overcoming chemoresistance.  \nKeywords: caffeic acid; vegetal sources; metabolism; adjuvant cancer treatment  \n1. Introduction  \nCaffeic acid (CA) was first identified by Hlasiwetz in 1867 during the hydrolysis of caffetannic acid using caustic potash [1] . CA is a naturally occurring polyphenol found widely in the plant kingdom","cbCaidQ4UQNk0wgJ","https://ap.wps.com/l/cbCaidQ4UQNk0wgJ","pdf",3039905,26,"English","# Abstract\n# Keywords\n# 1. Introduction\n## Origins and occurrence of caffeic acid\n## Structural features and antioxidant/pro-oxidant roles\n## Cellular mechanisms via ROS control\n## Nrf2/ARE pathway and phase II enzymes","[{\"question\":\"What is caffeic acid and where is it commonly found?\",\"answer\":\"Caffeic acid is a naturally occurring polyphenol found widely in plants, notably in beverages such as coffee and yerba mate. It belongs to the phenylpropanoid family.\"},{\"question\":\"How does caffeic acid exert antioxidant effects relevant to cancer?\",\"answer\":\"CA mitigates harmful reactive oxygen species that threaten DNA, proteins, and lipids, acting as a primary antioxidant. It also stimulates the Nrf2/ARE pathway to enhance intracellular antioxidant defenses.\"},{\"question\":\"What cancer-treatment adjunct benefits does the review highlight?\",\"answer\":\"The review links CA consumption to reduced risk of certain cancers, mitigation of chemotherapy and radiotherapy-induced toxicity, and reversal of resistance to first-line chemotherapeutic agents. It also notes that CA is generally safe with limited adverse effects reported.\"}]","Adjuvant Properties of Caffeic Acid in Cancer Treatment | PDF",1789991102,66]