[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-339384-105":3,"detail-sidebar-cat-0-en-105":81,"doc-detail-339384-en":130},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","adherence-to-the-mediterranean-diet-and-its-association-with-gastric-cancer-health-benefits-from-a-planeterranean-perspective","Adherence to the Mediterranean Diet and its association with gastric cancer - health benefits from a Planeterranean perspective","","The Mediterranean Diet (MD) is examined for its protective association with gastric cancer (GC), focusing on molecular and biological pathways. Antioxidant-rich and polyphenol-rich components are linked to modulation of gene expression, inhibition of tumor growth, and regulation of apoptosis. Evidence also highlights reduced inflammatory markers such as CRP, TNF-α, and IL-6, alongside anti-angiogenic effects from components including olive oil, red wine, fish, and tomatoes. The review further addresses intestinal microbiota changes that support immune homeostasis and lower systemic inflammation, while noting challenges in adherence scoring and the need for further gender- and region-specific studies.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/adherence-to-the-mediterranean-diet-and-its-association-with-gastric-cancer-health-benefits-from-a-planeterranean-perspective/339384/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/adherence-to-the-mediterranean-diet-and-its-association-with-gastric-cancer-health-benefits-from-a-planeterranean-perspective/339384.png","ImageObject",300,407,{"name":42,"@type":43},"Eliana","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-23","2026-09-21",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",9,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"How does the Mediterranean Diet relate to gastric cancer prevention?","Question",{"text":63,"@type":64},"The Mediterranean Diet is associated with gastric cancer risk reduction through anti-inflammatory, anti-angiogenic, and molecular mechanisms that may affect tumor development and survival.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"Which dietary components are highlighted for anti-angiogenic effects?",{"text":68,"@type":64},"Olive oil, red wine, fish, and tomatoes are emphasized as components with anti-angiogenic properties that may help reduce gastric cancer risk by inhibiting tumor angiogenesis.",{"name":70,"@type":61,"acceptedAnswer":71},"What challenges limit current evidence on diet adherence?",{"text":72,"@type":64},"Variability in dietary adherence scoring systems is noted, and further studies tailored to specific genders and geographic populations are required to strengthen conclusions.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},339384,1790122443,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,110,115,119,122,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":107,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":108,"slug":109},7,40,"healthcare",{"id":111,"doc_module":4,"doc_module_name":25,"category_name":112,"show_sort_weight":113,"slug":114},8,"Research & Report",30,"research-report",{"id":55,"doc_module":4,"doc_module_name":25,"category_name":116,"show_sort_weight":117,"slug":118},"Religion & Spirituality",20,"religion-spirituality",{"id":117,"doc_module":4,"doc_module_name":25,"category_name":120,"show_sort_weight":117,"slug":121},"World Cup","world-cup",{"id":123,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":123,"slug":125},10,"Lifestyle","lifestyle",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":97,"slug":129},19,"General","general",{"code":4,"msg":82,"data":131},{"doc_id":79,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":107,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":123,"language":139,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":12,"update_tm":143,"read_time":144},4398048949847,"https://ap-avatar.wpscdn.com/avatar/400002536579ef2da7f?_k=1778318612642679267","Reytor-González etal. Journal of Translational Medicine (2024) 22:483  \n[https://doi.org/10.1186/s12967-024-05176-w](https://doi.org/10.1186/s12967-024-05176-w)  \nJournal of Translational Medicine  \nREVIEW Open Access  \nAdherence to the Mediterranean Diet   and its association with gastric cancer: health benefits from a Planeterranean perspective  \nClaudia Reytor-González 1, Ana Karina Zambrano2, Martha Montalvan3,4, Evelyn Frias-Toral5, Alison Simancas-Racines6 and Daniel Simancas-Racines 1*  \nAbstract  \nThe Mediterranean Diet (MD) has garnered increasing attention for its potential protective effects against gastric cancer (GC) . The MD’s rich content of antioxidants, polyphenol s, and other bioactive compounds contributes to its ability to modulate gene expression, inhibit tumor growth, and regulate apoptosis. Studies have shown significant reductions in inflammatory markers such as C-reactive protein (CRP), tumor necrosis factor-alpha (TNF-α), and interleukin-6 (IL-6) among individuals adhering to the MD, suggesting its pivotal role in mitigating chronic inflammation-associated with cancer development. Furthermore, the MD’s anti-angiogenic properties, particularly in components like olive oil, red wine, fish, and tomatoes, offer promising avenues for reducing GC risk by inhibiting tumor angiogenesis. Additionally, the MD’s influence on intestinal microbiota composition underscores its potential in maintaining immune homeostasis and reducing systemic inflammation, factors crucial in GC prevention.  \nDespite challenges such as variability in dietary adherence scoring systems and the need for further gender and geographical-specific studies, evidence supports the MD as a cost-effective and holistic approach to GC prevention. Emphasizing the role of nutrition in public health is a promising strategy with broad implications for global health and cancer prevention initiatives. Therefore, this review explores the multifaceted impacts of the MD on GC prevention, delving into its anti-inflammatory, anti-angiogenic, and molecular mechanisms.  \nKeywords Gastric cancer, Mediterranean diet, Nutrition, Molecular mechanism, Planeterranean perspective  \n*Correspondence:  \nDaniel Simancas-Racines  \n[dsimancas@ute.edu.ec](dsimancas@ute.edu.ec)  \n1Centro de Investigación en Salud Pública y Epidemiología Clínica (CISPEC), Facultad de Ciencias de la Salud Eugenio Espejo, Universidad UTE, 170129 Quito, Ecuador  \n2Centro de Investigación Genética y Genómica, Facultad de Ciencias de la Salud Eugenio Espejo, Universidad UTE, Mariana de Jesús Ave, no number, 170129 Quito, Pichincha, Ecuador  \n3Universidad Católica Santiago de Guayaquil, . Pdte. Carlos Julio ArosemenaTola, 090615 Guayaquil, Ecuador  \n4School of Medicine, Universidad Católica Santiago de Guayaquil, Guayas, Guayaquil, Ecuador  \n5Escuela de Medicina, Universidad Espíritu Santo, 0901952 Samborondón, Ecuador  \n6Carrera de Medicina Veterinaria, Facultad de Ciencias Agropecuarias y Recursos Naturales, Universidad Técnica de Cotopaxi, 050108 Latacunga, Ecuador  \n© The Author(s) 2024. Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit [http://creativecommons.org/l](http://creativecommons.org/l)icenses/by/4.0/. The Creative Commons Public Domain Dedica","cbCaipdnDvb7xfJz","https://ap.wps.com/l/cbCaipdnDvb7xfJz","pdf",951719,"English","# Introduction\n# Mediterranean Diet and mechanisms relevant to gastric cancer\n## Anti-inflammatory pathways\n## Anti-angiogenic properties\n## Molecular mechanisms and gene regulation\n## Intestinal microbiota and immune homeostasis\n# Limitations and future research directions\n# Conclusion","[{\"question\":\"How does the Mediterranean Diet relate to gastric cancer prevention?\",\"answer\":\"The Mediterranean Diet is associated with gastric cancer risk reduction through anti-inflammatory, anti-angiogenic, and molecular mechanisms that may affect tumor development and survival.\"},{\"question\":\"Which dietary components are highlighted for anti-angiogenic effects?\",\"answer\":\"Olive oil, red wine, fish, and tomatoes are emphasized as components with anti-angiogenic properties that may help reduce gastric cancer risk by inhibiting tumor angiogenesis.\"},{\"question\":\"What challenges limit current evidence on diet adherence?\",\"answer\":\"Variability in dietary adherence scoring systems is noted, and further studies tailored to specific genders and geographic populations are required to strengthen conclusions.\"}]","Adherence to the Mediterranean Diet and its association with gastric cancer - health benefits from a Planeterranean perspective | PDF",1790029937,25]