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The study examines whether systemic inflammation changes influence the surgical effects on OSA, using associations between anatomical, questionnaire, polysomnographic, and inflammatory biomarker changes. Seventy-four children with OSA showed post-surgery improvements in OSA-18, multiple sleep parameters, and most biomarkers, with IL-8 and CCL5 mediating relationships.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/adenotonsillectomy-related-changes-in-systemic-inflammation-among-children-with-obstructive-sleep-apnea/436626/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/adenotonsillectomy-related-changes-in-systemic-inflammation-among-children-with-obstructive-sleep-apnea/436626.png","ImageObject",300,407,{"name":92,"@type":93},"Riley West","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-30","2026-09-29",true,{"@type":102,"interactionType":103,"userInteractionCount":52},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What question does this study address about adenotonsillectomy and OSA?","Question",{"text":112,"@type":113},"It evaluates whether systemic inflammation changes influence how adenotonsillectomy affects OSA in children, and how these inflammatory pathways may mediate surgical effects.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"Which outcomes improved after adenotonsillectomy?",{"text":117,"@type":113},"After surgery, the OSA-18 score, eight of 11 polysomnographic parameters, and 20 of 27 inflammatory biomarkers significantly improved (all p \u003C 0.005).",{"name":119,"@type":110,"acceptedAnswer":120},"How are tonsil size and OSA severity linked mechanistically in the results?",{"text":121,"@type":113},"Changes in tonsil size were associated with percent changes in AHI, and IL-8 and CCL5 showed serial mediation between tonsil size change and AHI change.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},436626,1790719308,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":52,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":52,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144,"preview_page_count":4},1099523885074,"https://ap-avatar.wpscdn.com/davatar_9964176cb1d06d4a9deccf72a44ae3dc","J Chin MedAssoc  \nOriginal article  \nAdenotonsillectomy-related changes in systemic inflammation among children with obstructive sleep apnea  \nChung-Guei Huanga,b,c, Jen-Fu Hsud,e, Li-Pang Chuange,f,g, Hsueh-Yu Lie,f,h, Tuan-Jen Fange,f,h, Yu-Shu Huange,f,i, Albert C. Yangj,k, Guo-She Leel,m, Terry B.J. Kuok,n,o, Cheryl C.H. Yangk,o, Li-Ang Leee,f,h,k,p,*, Hai-Hua Chuange,p,q,r,*  \naDepartment of Laboratory Medicine, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan, ROC; bDepartment of Medical Biotechnology and Laboratory Science, College of Medicine, Chang Gung University, Taoyuan, Taiwan, ROC; cResearch Center for Emerging Viral Infections, College of Medicine, Chang Gung University, Taoyuan, Taiwan, ROC; dDepartment of Pediatrics, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan, ROC; eFaculty of Medicine, Graduate Institute of Clinical Medicine Sciences, College of Medicine, Chang Gung University, Taoyuan, Taiwan, ROC; fSleep Center, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan, ROC; gDepartment of Pulmonary and Critical Care Medicine, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan, ROC; hDepartment of Otorhinolaryngology—Head and Neck Surgery, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan, ROC; iDepartment of Child Psychiatry, Linkou Chang Gung Memorial Hospital, Taoyuan, Taiwan, ROC; jDepartment of Psychiatry, Taipei Veterans General Hospital, Taipei, Taiwan, ROC; kInstitute of Brain Science, National Yang Ming Chiao Tung University, Taipei, Taiwan, ROC; lFaculty of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan, ROC; mDepartment of Otolaryngology, Taipei City Hospital, Ren-Ai Branch, Taipei, Taiwan, ROC; nCenter for Mind and Brain Medicine, Tsaotun Psychiatric Center, Ministry of Health and Welfare, Nantou, Taiwan, ROC; oSleep Research Center, National Yang Ming Chiao Tung University, Taipei, Taiwan, ROC; pSchool of Medicine, College of Life Science and Medicine, National Tsing Hua University, Hsinchu, Taiwan, ROC; qDepartment of Family Medicine, Chang Gung Memorial Hospital, Taipei Branch and Linkou Main Branch, Taoyuan, Taiwan, ROC; rDepartment of Industrial Engineering and Management, National Taipei University of Technology, Taipei, Taiwan, ROC  \nAbstract  \nBackground: Adenotonsillar hypertrophy is the most common cause of pediatric obstructive sleep apnea (OSA) . Although adenotonsillectomy considerably reduces OSA and systemic inflammation, whether and how systemic inflammation influences the effects of adenotonsillectomy on OSA has yet to be determined.  \nMethods: This study investigated the associations between changes in anatomical variables,% changes in subjective OSA-18 questionnaire scores,% changes in 11 polysomnographic parameters, and % changes in 27 systemic inflammatory biomarkers in 74 children with OSA.  \nResults: Fifty-six (75 .6%) boys and 18 (24 .4%) girls with the mean age of 7.4 ± 2.2 years and apnea-hypopnea index (AHI) of 14.2 ± 15.9 events/h were included in the statistical analysis. The mean period between before and after adenotonsillectomy was 5.6 ± 2.6 months. After adenotonsillectomy, the OSA-18 score, eight of 11 polysomnographic parameters, and 20 of 27 inflammatory biomarkers significantly improved (all p \u003C 0 .005) . Notably, there were significant associations between change in tonsil size and % change in AHI (r = 0 .23), change in tonsil size and % changes in interleukin-8 (IL-8) (r = 0 .34), change in tonsil size and % change in and IL-10 (r = -0 .36),% change in IL-8 and % change in C-C chemokine ligand 5 (CCL5) (r = 0.30), and % change in CCL5 and % change in AHI (r = 0 .38) (all p \u003C 0 .005) . Interestingly,% change in IL-8 and % change in CCL5 serially mediated the relationship between change in tonsil size and % change in AHI (total effect: β = 16.672, standard error = 8.274, p = 0.048) .  \nConclusion: These preliminary findings suggest that systemic inflammation is not only a complication of OSA but also that it mediates the surg","cbCaiqgppMJTtbWG","https://ap.wps.com/l/cbCaiqgppMJTtbWG","pdf",1494646,"English","# Abstract\n## Background\n## Methods\n## Results\n## Conclusion\n# Introduction","[{\"question\":\"What question does this study address about adenotonsillectomy and OSA?\",\"answer\":\"It evaluates whether systemic inflammation changes influence how adenotonsillectomy affects OSA in children, and how these inflammatory pathways may mediate surgical effects.\"},{\"question\":\"Which outcomes improved after adenotonsillectomy?\",\"answer\":\"After surgery, the OSA-18 score, eight of 11 polysomnographic parameters, and 20 of 27 inflammatory biomarkers significantly improved (all p \\u003c 0.005).\"},{\"question\":\"How are tonsil size and OSA severity linked mechanistically in the results?\",\"answer\":\"Changes in tonsil size were associated with percent changes in AHI, and IL-8 and CCL5 showed serial mediation between tonsil size change and AHI change.\"}]","Adenotonsillectomy-related changes in systemic inflammation among children with obstructive sleep apnea | PDF",1790678594,25]