[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-439924-105":3,"detail-sidebar-cat-0-en-105":81,"doc-detail-439924-en":130},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","addressing-rising-dengue-burden-in-pakistan-is-it-time-to-consider-dengue-vaccination","Addressing rising dengue burden in Pakistan - is it time to consider dengue vaccination?","","Short communication arguing for dengue vaccination consideration in Pakistan as dengue transmission expands across tropical and subtropical regions. It summarizes the virus’ clinical pattern and cites global and regional burden, including rising Pakistan case counts and provincial variation. It reviews current management as supportive care and vector control via integrated vector management, then frames vaccine development as a means to reduce transmission, morbidity, mortality, and healthcare-system strain. It also discusses vaccine-development challenges such as animal-model limits and immune interference.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/addressing-rising-dengue-burden-in-pakistan-is-it-time-to-consider-dengue-vaccination/439924/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/addressing-rising-dengue-burden-in-pakistan-is-it-time-to-consider-dengue-vaccination/439924.png","ImageObject",300,407,{"name":42,"@type":43},"McGucket","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-11-05","2026-09-29",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",8,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What evidence is provided about dengue trends in Pakistan?","Question",{"text":63,"@type":64},"The text reports a substantial increase in dengue cases in Pakistan over multiple years, including a sharp rise in June 2024. It also provides provincial and city-level case differences, highlighting Balochistan, Punjab, Khyber Pakhtunkhwa, Sindh, and urban centers such as Rawalpindi and Islamabad.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"How is dengue currently managed according to the article?",{"text":68,"@type":64},"There are no specific antiviral treatments described; clinical management is presented as supportive care. The approach focuses on attenuating inflammatory responses using analgesics, antipyretics, and intravenous fluids.",{"name":70,"@type":61,"acceptedAnswer":71},"Why does the article argue for considering dengue vaccination?",{"text":72,"@type":64},"It positions vaccines as a strategy to strengthen population immunity and complement vector control. The goal is to reduce disease incidence and severity, curb transmission, lower morbidity and mortality, and reduce economic and healthcare burdens in endemic settings.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},439924,1791090692,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,110,114,119,122,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":107,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":108,"slug":109},7,40,"healthcare",{"id":55,"doc_module":4,"doc_module_name":25,"category_name":111,"show_sort_weight":112,"slug":113},"Research & Report",30,"research-report",{"id":115,"doc_module":4,"doc_module_name":25,"category_name":116,"show_sort_weight":117,"slug":118},9,"Religion & Spirituality",20,"religion-spirituality",{"id":117,"doc_module":4,"doc_module_name":25,"category_name":120,"show_sort_weight":117,"slug":121},"World Cup","world-cup",{"id":123,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":123,"slug":125},10,"Lifestyle","lifestyle",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":97,"slug":129},19,"General","general",{"code":4,"msg":82,"data":131},{"doc_id":79,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":107,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":33,"language":139,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":12,"update_tm":143,"read_time":123,"preview_page_count":4},1236954412713,"https://us-avatar.wpscdn.com/davatar_29158cc5080c5b710cf443261637dec0","Short Communication  \n“Addressing rising dengue burden in Pakistan:is it time to consider dengue vaccination?”  \nMuhammad Momin Khan, MBBSa , Manaal Shakir, MBBSb , Sahir Bansari, MBBSc ,  \nBushra Azam Hashmi, MBBS, FCPSd , Farina Fatima Siddiqui, MBBSa , Muhammad Idrees, MBBSd ,Shahzad Hussain, MBBSd , Ajay Pandeya, MBBSe ,*  \nDear Editor,  \nIntroduction: background on dengue and its trendsin Pakistan  \nDengue virus (DENV 1–4), a member of the Flaviviridae family,is predominantly found in tropical and subtropical regions,including Southeast Asia, India, and Pakistan. Its transmissionis driven by outbreaks that are increasingly fueled by rapidurbanization, climate change, and expanding mosquito vectorpopulations [1] . It carries a significant burden worldwide with  \n13 million cases and 10 000 fatalities reported in 2024, thoughthe actual number is likely higher due to underreporting in low -and middle-income countries[2] . Usually, the disease presentswith sudden high-grade fever, headache, muscle and joint pain,rash, and nausea, which may progress to hemorrhage, multi -organ failure, and septic shock[2] . Inline with current best prac -tices for transparency and accountability in scientific reporting,this manuscript adheres to the TITAN guidelines for responsibledisclosure of AI assistance in research and writing[3] .  \nBurden analysis: national and regional statistics  \nRegionally, Bangladesh recorded 97 159 dengue cases and 532fatalities in 2024, while India reported 186 567 cases and 160deaths as of October 2024, with grim projections for 2025estimating up to 280 000 cases[4] . In contrast, Iran reportedfewer cases at 221, primarily attributed to imports from  \naDepartment of Internal Medicine, Liaquat University Hospital, Hyderabad, Sindh,Pakistan, bDepartment of Neurology, Punjab Institute of Neurosciences, Lahore,Punjab, Pakistan, cDepartment of Internal Medicine, Bilawal Medical College,Jamshoro, Sindh, Pakistan, dDepartment of Internal Medicine, Lahore GeneralHospital, Lahore, Punjab, Pakistan and eDepartment of Medicine, KIST MedicalCollege, Lalitpur, Nepal  \nSponsorships or competing interests that maybe relevant to content are disclosedatthe end of this article.  \n*Corresponding author. Address: KIST Medical College, Nepal.  \nTel: +9779847114074. E-mail: pandeyaajay100@gmail.com (A. Pandeya).Copyright © 2025 The Author(s). Published by Wolters Kluwer Health, Inc. This is anopen access article distributed under the Creative Commons Attribution License 4.0(CCBY), which permits unrestricted use, distribution, and reproduction in any medium,provided the original work is properly cited.  \nAnnals of Medicine & Surgery (2026) 88:1171–1174Received 23 May 2025; Accepted 29 September 2025  \nSupplemental Digital Content is available for this article. Direct URL citations areprovided in the HTML and PDF versions of this article on the journal’s website,www.lww.com/annals-of-medicine-and-surgery.  \nPublished online 7 November 2025  \nhttp://dx.doi.org/10.1097/MS9.0000000000004072  \nneighboring countries[5] . As of December 2024, Pakistan hasreported 20 000 dengue fever cases, including a sharp rise ofnearly 3000 cases in a single week in June[6] . With the regionalcalibration of dengue cases in Pakistan, the province ofBalochistan reported the highest case count at 6958, followedby Punjab (5405), Khyber Pakhtunkhwa (3649), and Sindh(1167) [6] . Rawalpindi emerged as the most affected urban centerin Pakistan, reporting 2143 cases, while the capital city,Islamabad, recorded 3754 cases[7] (Figure 1) . A significant risein the incidence of dengue has been experienced over the last 5years in Pakistan, as the country harbored 48 906 new denguecases and 183 deaths in 2021, followed by 41 746 cases and 62fatalities in 2022[8] . In the year 2023, the country encountered20 072 new cases [8] . Previously, 22 938 cases in 2017, over 3200in 2018, 24 547 in 2019, and 3442 cases in 2020 werereported[9] (Figure 2) . These fluctuating trends un","cbCaiilyku8S5RBq","https://ap.wps.com/l/cbCaiilyku8S5RBq","pdf",313261,"English","# Introduction\n# Burden analysis: national and regional statistics\n# Current control measures and limitations\n# Vaccine landscape: trials and mechanisms","[{\"question\":\"What evidence is provided about dengue trends in Pakistan?\",\"answer\":\"The text reports a substantial increase in dengue cases in Pakistan over multiple years, including a sharp rise in June 2024. It also provides provincial and city-level case differences, highlighting Balochistan, Punjab, Khyber Pakhtunkhwa, Sindh, and urban centers such as Rawalpindi and Islamabad.\"},{\"question\":\"How is dengue currently managed according to the article?\",\"answer\":\"There are no specific antiviral treatments described; clinical management is presented as supportive care. The approach focuses on attenuating inflammatory responses using analgesics, antipyretics, and intravenous fluids.\"},{\"question\":\"Why does the article argue for considering dengue vaccination?\",\"answer\":\"It positions vaccines as a strategy to strengthen population immunity and complement vector control. The goal is to reduce disease incidence and severity, curb transmission, lower morbidity and mortality, and reduce economic and healthcare burdens in endemic settings.\"}]","Addressing rising dengue burden in Pakistan - is it time to consider dengue vaccination? | PDF",1790690540]