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Adult recipients undergo pre- and postoperative modified barium swallow studies with synchronized respiratory signal capture from videofluoroscopy. Outcomes quantify impairment using the Modified Barium Swallow Impairment Profile and airway invasion with the Penetration-Aspiration Scale. After transplantation, swallowing impairment and laryngeal penetration/aspiration worsen, linked to atypical respiratory-swallow patterning and reduced laryngeal elevation and airway protection.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/acute-impact-of-lung-transplantation-on-respiratory-swallow-coordination-a-prospective-cohort-study/411700/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/acute-impact-of-lung-transplantation-on-respiratory-swallow-coordination-a-prospective-cohort-study/411700.png","ImageObject",300,407,{"name":92,"@type":93},"Marglet","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-04","2026-09-28",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",11,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"How does lung transplantation affect swallowing impairment after surgery?","Question",{"text":113,"@type":114},"Swallowing impairment significantly worsens after lung transplantation, with post-transplant status associated with greater impairment across multiple physiologic swallowing components (p \u003C 0.05).","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"What is the study design and how are swallowing events analyzed?",{"text":118,"@type":114},"The study uses a prospective cohort design of adult lung transplant recipients undergoing pre- and postoperative modified barium swallow studies, with respiratory signals synchronously captured and linked to respiratory phase preceding swallowing events.",{"name":120,"@type":111,"acceptedAnswer":121},"Which respiratory-swallow patterns are associated with impaired airway protection?",{"text":122,"@type":114},"After lung transplantation, atypical respiratory-swallow patterning is significantly associated with impaired laryngeal elevation and laryngeal vestibular closure, and with increased airway invasion (reported with odds ratios and 95% CIs).","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},411700,1790816465,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":52,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145,"preview_page_count":4},2336477982702,"https://ap-avatar.wpscdn.com/davatar_9964176cb1d06d4a9deccf72a44ae3dc","[https://www.jhltopen.org/](https://www.jhltopen.org/)  \nAcute impact of lung transplantation on respiratory-swallow coordination, swallowing impairment, and airway invasion: A prospective cohort study  \nKahla Graham, PhD,a,⁎ Jungwha Julia Lee, PhD,b Rade Tomic, MD,c Ambalavanan Arunachalam, MD,d and Bonnie Martin-Harris, PhDa,e  \naRoxelyn and Richard Pepper Department of Communication Sciences and Disorders, School of Communication, Northwestern University, Evanston, IL  \nbDepartment of Preventive Medicine (Biostatistics), Feinberg School of Medicine, Northwestern University, Chicago, IL cSection of Pulmonary and Critical Care Medicine, UChicago Medicine, Biological Sciences Division, The University of Chicago, Chicago, IL  \ndDivision of Pulmonary and Critical Care Medicine, Northwestern Memorial Hospital, Feinberg School of Medicine, Northwestern University, Chicago, IL  \neDepartment of Otolaryngology-Head & Neck Surgery, Radiation Oncology, Feinberg School of Medicine, Northwestern University, Chicago, IL  \nKEYWORDS:  \nSwallowing; Aspiration; Oropharyngeal dysphagia;  \nDysphagia; Lung transplant  \nBACKGROUND: Lung transplant recipients possess premorbid risk factors for swallowing impairment and airway invasion, including potential alterations in respiratory-swallow coordination. Although aspiration is highly prevalent after lung transplantation, the impact of lung transplantation, its procedures, and postoperative pain management on respiration and swallowing are not understood. METHODS: A prospective cohort study of adult lung transplant recipients referred for pre- and postoperative modified barium swallow studies. Respiratory signals were synchronously captured with videofluoroscopic images and analyzed to determine the respiratory phase preceding swallowing events. Swallowing impairment and airway invasion were analyzed using the Modified Barium Swallow Impairment Profile and Penetration-Aspiration Scale (PAS) . Wilcoxon signed-rank tests, paired t-tests, and mixed effects models were conducted.  \nRESULTS: Twenty-eight patients were included. Sixty-nine percent of swallows were initiated during expiration before (173/252) and after (166/239) lung transplantation; however, individual variability was noted. Swallowing impairment significantly worsened after lung transplantation, and post-transplant status was associated with greater impairment in 10 physiologic swallowing components and laryngeal penetration/aspiration (p \u003C 0.05) . After lung transplantation, atypical respiratory-swallow patterning was significantly associated with impaired laryngeal elevation (OR [95% CI] = 2.13 [1.20, 3.76] p = 0.009), laryngeal vestibular closure (OR [95% CI] = 1.62 [1.12, 2.35] p = 0.010), and airway invasion (OR [95% CI] = 1.95 [1.18, 3.23] p = 0.009) .  \nAbbreviations: BMI, Body mass index; CI, Confidence interval; CLAD, Chronic lung allograft dysfunction; MBSImP, Modified barium swallow impairment profile; MBSS, Modified barium swallow study; OI, Overall impression; OR, Odds ratio; OT, Oral total; PAS, Penetration-aspiration scale; PES,  \nPharyngoesophageal segment; POD, Postoperative day; PT, Pharyngeal total; SD, Standard deviation ⁎Corresponding author: Kahla Graham, PhD, Northwestern University, 2240 Campus Drive, Evanston, IL 60208.  \nE-mail [address:](address: Kahla.graham@northwestern.edu)[ Kahla.graham@northwestern.edu](address: Kahla.graham@northwestern.edu).  \n2950-1334/© 2025 The Authors. Published by Elsevier Inc. on behalf of International Society for Heart and Lung Transplantation. This is an open access article under the CC BY-NC-ND license ([http://creativecommons.org/licenses/by-nc-nd/4.0/](http://creativecommons.org/licenses/by-nc-nd/4.0/)).  \n[https://doi.org/10.1016/j.jhlto.2025.100402](https://doi.org/10.1016/j.jhlto.2025.100402)  \nCONCLUSION: Swallowing impairment and airway invasion worsened after lung transplantation and were associated with atypical respiratory-swallow patterning. These findings suggest ac","cbCaimIaM2okUVpp","https://ap.wps.com/l/cbCaimIaM2okUVpp","pdf",1797136,"English","# Background\n# Methods\n# Results\n# Conclusion\n# References (as cited)","[{\"question\":\"How does lung transplantation affect swallowing impairment after surgery?\",\"answer\":\"Swallowing impairment significantly worsens after lung transplantation, with post-transplant status associated with greater impairment across multiple physiologic swallowing components (p \\u003c 0.05).\"},{\"question\":\"What is the study design and how are swallowing events analyzed?\",\"answer\":\"The study uses a prospective cohort design of adult lung transplant recipients undergoing pre- and postoperative modified barium swallow studies, with respiratory signals synchronously captured and linked to respiratory phase preceding swallowing events.\"},{\"question\":\"Which respiratory-swallow patterns are associated with impaired airway protection?\",\"answer\":\"After lung transplantation, atypical respiratory-swallow patterning is significantly associated with impaired laryngeal elevation and laryngeal vestibular closure, and with increased airway invasion (reported with odds ratios and 95% CIs).\"}]","Acute impact of lung transplantation on respiratory-swallow coordination - A prospective cohort study | PDF",1790589402,25]