[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-detail-32328":3,"doc-seo-32328":28},{"code":4,"msg":5,"data":6},0,"success",{"doc_id":7,"user_id":8,"nickname":9,"user_avatar":10,"doc_module":4,"category_id":11,"category_name":12,"doc_title":13,"doc_description":14,"file_id":15,"file_url":16,"file_type":17,"file_size":18,"view_count":19,"is_deleted":4,"is_public":20,"is_downloadable":20,"audit_status":20,"page_count":21,"language":22,"language_code":23,"table_of_contents":24,"faqs":25,"seo_title":13,"seo_description":14,"update_tm":26,"read_time":27},32328,16904993612988,"Olivia Brown","https://ap-avatar.wpscdn.com/davatar_a8503ba1806abce46bf441b54a3ca4cd",8,"Research & Report","Acute Heart Failure Syndrome: Pathophysiology and Management Needs","Acute heart failure (AHF) is defined by new onset or acute worsening of heart failure symptoms and signs, largely driven by systemic congestion. Underlying structural or functional cardiac dysfunction and precipitating factors create highly heterogeneous pathophysiology, where altered left ventricular diastolic or systolic function increases preload and afterload, causing pulmonary congestion and later systemic hypoperfusion-related organ dysfunction. Current care is mainly symptomatic decongestion with limited targeting of mechanisms, leaving high mortality and readmission rates and a need for individualized in-hospital and post-discharge management.","cbCaijOhdlyw1M7A","https://ap.wps.com/l/cbCaijOhdlyw1M7A","pdf",1671990,2,1,15,"English","en","# Overview of Acute Heart Failure\n## Definition and Clinical Features\n## Heterogeneous Pathophysiology\n## Current Treatment and Unmet Needs","[{\"question\":\"What defines acute heart failure (AHF)?\",\"answer\":\"AHF is defined as the new onset of heart failure or the acute worsening of pre-existing heart failure, typically associated with systemic congestion.\"},{\"question\":\"What mechanisms connect left ventricular dysfunction to organ dysfunction in AHF?\",\"answer\":\"Left ventricular diastolic or systolic impairment increases preload and afterload, leading to pulmonary congestion; fluid retention and redistribution then cause systemic congestion and organ dysfunction through hypoperfusion.\"},{\"question\":\"Why is current AHF treatment considered insufficient?\",\"answer\":\"Treatment is mostly symptomatic and decongestive, often tailored mainly to initial hemodynamics rather than underlying pathophysiology, resulting in persistent high mortality and hospital readmission rates.\"}]",1781126598,38,{"code":4,"msg":29,"data":30},"ok",{"site_id":31,"language":23,"slug":32,"title":13,"keywords":33,"description":14,"schema_data":34,"social_meta":85,"head_meta":87,"extra_data":89,"updated_unix":26},105,"acute-heart-failure-syndrome-pathophysiology-and-management-needs","",{"@graph":35,"@context":84},[36,52,67],{"@type":37,"itemListElement":38},"BreadcrumbList",[39,43,46,49],{"item":40,"name":41,"@type":42,"position":20},"https://docshare.wps.com","Home","ListItem",{"item":44,"name":45,"@type":42,"position":19},"https://docshare.wps.com/document/","Document",{"item":47,"name":12,"@type":42,"position":48},"https://docshare.wps.com/document/research-report/",3,{"item":50,"name":13,"@type":42,"position":51},"https://docshare.wps.com/document/acute-heart-failure-syndrome-pathophysiology-and-management-needs/32328/",4,{"url":50,"name":13,"@type":53,"author":54,"headline":13,"publisher":56,"fileFormat":59,"description":14,"dateModified":60,"datePublished":61,"encodingFormat":59,"isAccessibleForFree":62,"interactionStatistic":63},"DigitalDocument",{"name":9,"@type":55},"Person",{"url":40,"name":57,"@type":58},"DocShare","Organization","application/pdf","2026-06-12","2026-06-10",true,{"@type":64,"interactionType":65,"userInteractionCount":19},"InteractionCounter",{"@type":66},"ViewAction",{"@type":68,"mainEntity":69},"FAQPage",[70,76,80],{"name":71,"@type":72,"acceptedAnswer":73},"What defines acute heart failure (AHF)?","Question",{"text":74,"@type":75},"AHF is defined as the new onset of heart failure or the acute worsening of pre-existing heart failure, typically associated with systemic congestion.","Answer",{"name":77,"@type":72,"acceptedAnswer":78},"What mechanisms connect left ventricular dysfunction to organ dysfunction in AHF?",{"text":79,"@type":75},"Left ventricular diastolic or systolic impairment increases preload and afterload, leading to pulmonary congestion; fluid retention and redistribution then cause systemic congestion and organ dysfunction through hypoperfusion.",{"name":81,"@type":72,"acceptedAnswer":82},"Why is current AHF treatment considered insufficient?",{"text":83,"@type":75},"Treatment is mostly symptomatic and decongestive, often tailored mainly to initial hemodynamics rather than underlying pathophysiology, resulting in persistent high mortality and hospital readmission rates.","https://schema.org",{"og:url":50,"og:type":86,"og:title":13,"og:site_name":57,"og:description":14},"article",{"robots":88,"canonical":50},"index,follow",{"doc_id":7,"site_id":31}]