[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-384936-105":59,"doc-detail-384936-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","active-ingredients-from-chinese-medicine-for-combination-cancer-therapy","Active Ingredients from Chinese Medicine for Combination Cancer Therapy","","Combination therapy against cancer increasingly targets multiple pathways to overcome the limited efficacy and side effects of single-agent treatment. Chinese medicine has been widely studied and shown to provide broad anticancer activity. This review summarizes recent progress of active ingredients from Chinese medicine (AIFCM) combined with chemotherapy, gene therapy, radiotherapy, phototherapy, and immunotherapy. It also explains mechanisms for synergistic effects and improved anticancer performance, and addresses challenges and future directions for clinical optimization.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/active-ingredients-from-chinese-medicine-for-combination-cancer-therapy/384936/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/active-ingredients-from-chinese-medicine-for-combination-cancer-therapy/384936.png","ImageObject",300,407,{"name":92,"@type":93},"Riley West","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-25","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":52},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"Why is combination therapy important in cancer treatment?","Question",{"text":112,"@type":113},"Combination therapy can target multiple pathways, improve therapeutic outcomes, enhance tumor growth inhibition, reduce adverse effects, resensitize drugs, and inhibit relapse and metastasis compared with single-modality therapy.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What role do active ingredients from Chinese medicine (AIFCM) play in combination therapy?",{"text":117,"@type":113},"AIFCM can induce tumor inhibition, increase tumor sensitivity to other therapies, improve immune function, and inhibit angiogenesis and metastasis, supporting synergistic anticancer efficacy.",{"name":119,"@type":110,"acceptedAnswer":120},"Which cancer therapeutic modalities are covered for AIFCM combination use?",{"text":121,"@type":113},"The review focuses on combinations with chemotherapy, gene therapy, radiotherapy, phototherapy, and immunotherapy.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},384936,1790618790,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":52,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145},1099523885074,"https://ap-avatar.wpscdn.com/davatar_9964176cb1d06d4a9deccf72a44ae3dc","Ivyspring  \nInternational Publisher  \nInternationalJournal of Biological Sciences  \n2023; 19(11): 3499-3525. doi: 10.7150/ijbs.77720  \nReview  \nActive Ingredients from Chinese Medicine for Combination Cancer Therapy  \nXuan Wang1†, Jing Li1†, Ruie Chen1, Ting Li2, Meiwan Chen1,3􀀍  \n1. State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, 999078, China.  \n2. State Key Laboratory of Quality Research in Chinese Medicines, Macau Institute for Applied Research in Medicine and Health, Macau University of Science and Technology, Macau, 999078, China.  \n3. MoE Frontiers Science Center for Precision Oncology, University of Macau, Macau, 999078, China.  \n†These authors contribute equally to this work.  \n􀀍 Corresponding author: Tel.: +853-8822-4675; E-[mail: mwchen@um.edu.mo](mail: mwchen@um.edu.mo) (M.W. Chen) .  \n© The author(s). This is an open access article distributed under the terms of the Creative Commons Attribution License ([https://creativecommons.org/licenses/by/4.0/](https://creativecommons.org/licenses/by/4.0/)). See [http://ivyspring.com/terms](http://ivyspring.com/terms) for full terms and conditions.  \nReceived: 2022.08.03; Accepted: 2023.03.26; Published: 2023.07.09  \nAbstract  \nCombination therapy against cancer has gained increasing attention because it can help to target multiple pathways to tackle oncologic progression and improve the limited antitumor effect of single-agent therapy. Chinese medicine has been studied extensively in cancer therapy and proven to be efficacious in many cases due to its wide spectrum of anticancer activities. In this review, we aim to summarize the recent progress of active ingredients from Chinese medicine (AIFCM) in combination with various cancer therapeutic modalities, including chemotherapy, gene therapy, radiotherapy, phototherapy and immunotherapy. In addition to highlighting the potential contribution of AIFCM in combination cancer therapy, we also elucidate the underlying mechanisms behind their synergistic effect and improved anticancer efficacy, thereby encouraging the inclusion of these AIFCM as part of effective armamentariumin fighting intractable cancers. Finally, we present the challenges and future perspectives of AIFCM combination therapy as a feasible and promising strategy for the optimization of cancer treatment and better clinical outcomes.  \nKeywords: Chinese medicine; Active ingredients; Combination cancer therapy; Nanomedicine  \n1. Introduction  \nCancer is still a major threat to public health and one of the leading causes of mortality worldwide [1] . Extensive efforts have been made to develop various cancer treatment modalities, including surgery, chemotherapy, gene therapy, radiotherapy, phototherapy, and immunotherapy. However, owing to the physiological heterogeneity of cancer and certain obstacles such as the drug resistance of therapeutic agents, limited tumoricidal penetration depth of phototherapy, radioresistance and immune tolerance, these monotherapies often exhibit limited therapeutic outcomes and have inevitable side effects or adverse reactions to cancer patients in clinical practice [2] . To address these challenges, a variety of anticancer strategies have been developed. Combination therapy, which makes use of different therapeutic modalities, is regarded as one of the most promising  \noptions among these treatments. It can inhibit cancer through complementary mechanisms and yield favorable therapeutic outcomes, such as enhanced tumor growth inhibition, reduced adverse effects, drug resensitization, lowered relapse rate and metastasis inhibition [3, 4] . Therefore, a better understanding of the mechanisms underlying of different combination therapy strategies would be meaningful for cancer treatment [5] .  \nChinese medicine, an important component of complementary and alternative medicine in the world, is supported by rich clinical experience gleaned over thousands of year","cbCaibFqaT9VMHgY","https://ap.wps.com/l/cbCaibFqaT9VMHgY","pdf",6328641,27,"English","# Abstract\n# Introduction\n## Cancer treatment challenges and rationale for combination therapy\n## Chinese medicine as a complementary approach\n# Progress of AIFCM in combination modalities\n## Mechanisms and synergistic anticancer effects\n## Nanocarrier-based delivery applications\n# Challenges and future perspectives","[{\"question\":\"Why is combination therapy important in cancer treatment?\",\"answer\":\"Combination therapy can target multiple pathways, improve therapeutic outcomes, enhance tumor growth inhibition, reduce adverse effects, resensitize drugs, and inhibit relapse and metastasis compared with single-modality therapy.\"},{\"question\":\"What role do active ingredients from Chinese medicine (AIFCM) play in combination therapy?\",\"answer\":\"AIFCM can induce tumor inhibition, increase tumor sensitivity to other therapies, improve immune function, and inhibit angiogenesis and metastasis, supporting synergistic anticancer efficacy.\"},{\"question\":\"Which cancer therapeutic modalities are covered for AIFCM combination use?\",\"answer\":\"The review focuses on combinations with chemotherapy, gene therapy, radiotherapy, phototherapy, and immunotherapy.\"}]","Active Ingredients from Chinese Medicine for Combination Cancer Therapy | PDF",1790266006,68]