[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-420449-105":3,"detail-sidebar-cat-0-en-105":81,"doc-detail-420449-en":131},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","acralangioleiomyoma-with-tumoral-calcinosis-a-rare-case-report-and-literature-review","AcralAngioleiomyoma With Tumoral Calcinosis - A Rare Case Report and Literature Review","","Angioleiomyoma is a benign pericytic neoplasm that usually arises in the dermis or subcutis of the lower extremities, while extensive calcification is exceptionally rare. A case report describes an 80-year-old woman with a 20-year history of a slowly growing, painless mass at the left great toe; imaging showed a well-calcified, well-demarcated lesion without bone involvement. Excisional biopsy and histology demonstrated benign smooth muscle bundles with vascular channels and calcified deposits with epithelioid histiocytes and giant cells, with no local recurrence at latest follow-up.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/acralangioleiomyoma-with-tumoral-calcinosis-a-rare-case-report-and-literature-review/420449/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/acralangioleiomyoma-with-tumoral-calcinosis-a-rare-case-report-and-literature-review/420449.png","ImageObject",300,407,{"name":42,"@type":43},"anakgang17","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-30","2026-09-28",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",15,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What is acral calcified angioleiomyoma, and why is it rare?","Question",{"text":63,"@type":64},"Angioleiomyoma is a benign pericytic (perivascular) tumor. Extensive calcification is extremely uncommon in this condition, making “acral calcified angioleiomyoma” rare.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"How did the patient present clinically in this case report?",{"text":68,"@type":64},"An 80-year-old woman had a slowly growing, painless mass for 20 years on the dorsomedial aspect of the left great toe. Examination showed a 2.5-cm firm, mobile, non-tender mass.",{"name":70,"@type":61,"acceptedAnswer":71},"What imaging and histological findings supported the diagnosis?",{"text":72,"@type":64},"Radiographs and CT showed a densely calcified, well-demarcated lesion without bone involvement. MRI demonstrated characteristic signal patterns and intense enhancement in the non-calcified portion; histology showed bland smooth muscle bundles with slit-like vascular channels and calcium deposits surrounded by epithelioid histiocytes and multinucleated giant cells.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},420449,1790742787,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,110,115,120,123,127],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":107,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":108,"slug":109},7,40,"healthcare",{"id":111,"doc_module":4,"doc_module_name":25,"category_name":112,"show_sort_weight":113,"slug":114},8,"Research & Report",30,"research-report",{"id":116,"doc_module":4,"doc_module_name":25,"category_name":117,"show_sort_weight":118,"slug":119},9,"Religion & Spirituality",20,"religion-spirituality",{"id":118,"doc_module":4,"doc_module_name":25,"category_name":121,"show_sort_weight":118,"slug":122},"World Cup","world-cup",{"id":124,"doc_module":4,"doc_module_name":25,"category_name":125,"show_sort_weight":124,"slug":126},10,"Lifestyle","lifestyle",{"id":128,"doc_module":4,"doc_module_name":25,"category_name":129,"show_sort_weight":97,"slug":130},19,"General","general",{"code":4,"msg":82,"data":132},{"doc_id":79,"user_id":133,"nickname":42,"user_avatar":134,"doc_module":4,"category_id":107,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":107,"language":140,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":12,"update_tm":144,"read_time":145,"preview_page_count":4},962090883568,"https://ap-avatar.wpscdn.com/davatar_a8503ba1806abce46bf441b54a3ca4cd","doi: 10.21873/invivo.14218  \nAcralAngioleiomyoma With Tumoral Calcinosis: A Rare Case Report and Literature Review  \nYUKI SHINOHARA, YOSHIRO CHIJIIWA and JUN NISHIO  \nSection of Orthopaedic Surgery, Department of Medicine, Fukuoka Dental College, Fukuoka, Japan  \nAbstract  \nBackground/Aim: Angioleiomyoma is a benign, pericytic (perivascular) neoplasm that most frequently arises in the dermis or subcutis of the lower extremities. Extensive calcification is extremely uncommon in this condition.  \nCase Report: An 80-year-old woman presented with a 20-year history of a slowly growing, painless mass in the dorsomedial aspect of the left great toe. Physical examination revealed a 2.5-cm, firm, mobile, non-tender mass. Radiographs showed a well-demarcated, densely calcified mass. Computed tomography confirmed the presence of a calcified lesion without bone involvement. Magnetic resonance imaging (MRI) exhibited a well-defined mass with intermediate signal intensity on T1-weightwed sequences and high signal intensity on T2-weighted sequences. Peripheral low signal intensity areas correlating to the calcified portion of the mass were also observed on both T1-and T2-weighted sequences. Contrast-enhanced MRI demonstrated intense, relatively homogeneous enhancement in the non-calcified portion of the mass. The patient underwent an excisional biopsy of the lesion. Histologically, the lesion is composed of bundles of bland, well-differentiated smooth muscle cells with small slit-like vascular channels. In addition, calcium crystal deposits surrounded by aggregates of epithelioid histiocytes and multinucleated giant cells were observed. The patient had no evidence of local recurrence at the latest follow-up.  \nConclusion: This unique case provides valuable insights into the understanding and treatment of acral calcified angioleiomyoma. Knowledge of this peculiar neoplasm is important because it can mimic a variety of benign and malignant soft-tissue tumors.  \nKeywords: Angioleiomyoma, tumoral calcinosis, calcification, foot.  \nIntroduction  \nAngioleiomyoma, also known as vascular leiomyoma, is a distinctive benign soft-tissue tumor originating from the smooth muscle layer of blood vessels (1). According to the  \nlatest World Health Organization classification of softtissue tumors, it belongs to the group of pericytic (perivascular) tumors (2) . Angioleiomyoma comprises about 4.4% of all benign soft-tissue tumors and 0.2% of all tumors of the foot and ankle (3) . The etiology of this  \n✉ Jun Nishio, MD, PhD, Section of Orthopaedic Surgery, Department of Medicine, Fukuoka  \nSawara-ku, Fukuoka 814-0193, Japan. Tel: +81 928010411, Fax: +81 928010735, e-mail:  \nReceived September 17, 2025 | Revised October 7, 2025 | Accepted October 23, 2025  \nDental College, 2-15-1 Tamura, [nishio@fdcnet.ac.jp](nishio@fdcnet.ac.jp)  \nThis is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.  \n©2026 The Author(s) . Anticancer Research is published by the International Institute of Anticancer Research.  \nTable I. Main clinical features of patients with acral calcified angioleiomyoma.  \n\n| Case | Age (years)/sex | Site | Size (cm) | Treatment | Reference |\n| --- | --- | --- | --- | --- | --- |\n| 1 | 70/F | Left index finger | 3.0 × 2.0 | Excision | Kacerovska etal. (4) |\n| 2 | 72/F | Right sole | 5.0 | Excision | Kacerovska etal. (4) |\n| 3 | 57/F | Right heel | 2.5 × 2.0 | Excision | Kacerovska etal. (4) |\n| 4 | 75/F | Right sole | 2.0 × 2.0 | Excision | Sakai et al. (5) |\n| 5 | 52/F | Left foot | 0.5 | Excision | Gómez-Bernal et al. (6) |\n| 6 | 71/F | Right foot | 2.0 | Excision | Blalock et al. (7) |\n| 7 | 52/F | Foot | NA | NA | Díaz-Flores et al. (8) |\n| 8 | 63/F | Foot | NA | NA | Díaz-Flores et al. (8) |\n| 9 | 68/F | Left sole | 2.0 | Excision | Suárez-Peñaranda et al. (9) |\n| 10 | 69/M | Left heel | 1.6 | Excision | ","cbCaiekPUgJAqaha","https://ap.wps.com/l/cbCaiekPUgJAqaha","pdf",1436602,"English","# Abstract\n# Introduction\n# Case Report\n# Conclusion","[{\"question\":\"What is acral calcified angioleiomyoma, and why is it rare?\",\"answer\":\"Angioleiomyoma is a benign pericytic (perivascular) tumor. Extensive calcification is extremely uncommon in this condition, making “acral calcified angioleiomyoma” rare.\"},{\"question\":\"How did the patient present clinically in this case report?\",\"answer\":\"An 80-year-old woman had a slowly growing, painless mass for 20 years on the dorsomedial aspect of the left great toe. Examination showed a 2.5-cm firm, mobile, non-tender mass.\"},{\"question\":\"What imaging and histological findings supported the diagnosis?\",\"answer\":\"Radiographs and CT showed a densely calcified, well-demarcated lesion without bone involvement. MRI demonstrated characteristic signal patterns and intense enhancement in the non-calcified portion; histology showed bland smooth muscle bundles with slit-like vascular channels and calcium deposits surrounded by epithelioid histiocytes and multinucleated giant cells.\"}]","AcralAngioleiomyoma With Tumoral Calcinosis - A Rare Case Report and Literature Review | PDF",1790621045,18]