[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-458907-105":59,"doc-detail-458907-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","acral-speckled-lentiginous-nevus-open-access-case-report","Acral Speckled Lentiginous Nevus - open access case report","","Speckled lentiginous nevus (SLN), also called nevus spilus, is a common benign melanocytic lesion appearing as a small café-au-lait–colored speckled patch with many dark macules or papules. A unique case is reported: SLN on the sole of the right foot in a young woman, gradually enlarging since pregnancy. Shave biopsy removal and histopathology confirmed benign acral nevus spilus and excluded atypia. The mosaic RASopathy mechanism and clinical guidance are discussed, including low malignant risk and when to consider SLN syndrome.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/acral-speckled-lentiginous-nevus-open-access-case-report/458907/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/acral-speckled-lentiginous-nevus-open-access-case-report/458907.png","ImageObject",300,407,{"name":92,"@type":93},"Indoniesian Boy","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-31","2026-09-30",true,{"@type":102,"interactionType":103,"userInteractionCount":39},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is speckled lentiginous nevus (SLN) and how is it typically described?","Question",{"text":112,"@type":113},"SLN (nevus spilus) is a common benign melanocytic neoplasm that usually presents as a small café-au-lait–colored “speckled” patch with numerous darkly pigmented macules or papules.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How was the diagnosis confirmed in this patient?",{"text":117,"@type":113},"A shave biopsy was performed, and hematoxylin and eosin histopathology showed benign compound features with a lentiginous junctional component and minimal atypia; PRAME immunohistochemistry was negative.",{"name":119,"@type":110,"acceptedAnswer":120},"Why is acral SLN clinically notable?",{"text":121,"@type":113},"Acral SLN is extremely rare in the literature, making the reported occurrence on the sole of the foot novel. The case highlights diagnostic considerations for special-site lesions.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},458907,1790784091,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":39,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":24,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144,"preview_page_count":4},962090760608,"https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c","Open Access Case Report  \nAcral Speckled Lentiginous Nevus  \nReview began 11/17/2025  \nReview ended 12/04/2025  \nPublished 12/09/2025  \n© Copyright 2025  \nMaverakis Ramirez et al. This is an open access article distributed under the terms of the Creative Commons Attribution License CC-BY 4.0. , which permits unrestricted use , distribution , and reproduction in any medium , provided the original author and source are credited.  \nDOI: 10.7759/cureus.98813  \nNatalia Maverakis Ramirez 1, Zachary J. Jaeger 2, Hadas Skupsky 3, Anne Marie McNeill 4 , Antoanella Calame 3, 5  \n1. School of Medicine, San Juan Bautista School of Medicine, Caguas, USA 2. Dermatology, University of California San Diego, San Diego, USA 3. Dermatology/Dermatopathology, Compass Dermatopathology, San Diego, USA 4. Dermatology, Newport Beach Dermatology and Plastic Surgery, Newport Beach, USA 5. Dermatology, Scripps Memorial Hospital, San Diego, USA  \nCorresponding author: Natalia Maverakis Ramirez, [nkm263@nyu.edu](nkm263@nyu.edu)  \nAbstract  \nSpeckled lentiginous nevus (SLN), also referred to as nevus spilus, is a common benign melanocytic neoplasm typically occurring as a small, café-au-lait-colored “speckled” patch studded with numerous darkly pigmented macules or papules. Herein, we present a unique case of SLN arising on the sole of the right foot in a young woman, which was reported to be gradually enlarging since a pregnancy two years prior. The lesion was removed by shave biopsy, and histopathology confirmed the diagnosis and ruled out atypical features. While SLN is quite common, the occurrence on acral skin is extremely rare. SLN is considered a mosaic RASopathy due to its embryological development through a postzygotic activating HRAS genetic variant. Although small lesions usually remain isolated, underlying SLN syndrome should be considered in extensive cases with associated neurologic or musculoskeletal abnormalities. Secondary melanocytic neoplasms commonly arise within SLN, but overall, small lesions carry a low risk of malignant transformation, and prophylactic surgical treatment is not necessary. We briefly discuss SLN occurring in special sites and report this novel case with a review of the literature on SLN.  \nCategories: Genetics, Pathology, Dermatology  \nKeywords: acral nevus, compound nevus, congenital nevus, melanocytic nevus, melanoma, nevi spili, nevus spilus, special site nevus, speckled lentiginous nevus  \nIntroduction  \nSpeckled lentiginous nevus (SLN), also referred to as nevus spilus, is a common benign melanocytic  \nneoplasm typically occurring as a small, isolated patch studded with numerous darkly pigmented macules.  \nMacular SLN tends to have an evenly distributed checkerboard pattern of pigmented macules throughout thenevus [1] . The reported prevalence is around 1-3%, similar to that of congenital melanocytic nevi [1,2] . Here, we present a unique case of SLN arising on an acral surface and briefly discuss SLN occurring in special sites, as nevi on special sites have historically posed diagnostic challenges.  \nCase Presentation  \nA 28-year-old woman with a history of two basal cell carcinomas presented to the dermatology clinic for anasymptomatic birthmark on the sole of the right foot, gradually enlarging since a pregnancy two years ago (Figure 1) . A shave biopsy was performed to sample a portion of the lesion. On hematoxylin and eosin (H &E) staining, the lesion demonstrated a benign compound histomorphology, with congenital dermal features and a lentiginous junctional component containing scattered nests and minimal site-related cytologic atypia (Figures 2A-2D) . Regular columns of melanin peppered the stratum corneum. Preferentially expressed antigen in melanoma (PRAME) immunohistochemistry was negative. Therefore, the diagnosis of benign acral nevus spilus was rendered.  \nHow to cite this article  \nMaverakis Ramirez N , Jaeger Z J , Skupsky H , et al. (December 09 , 2025) Acral Speckled Lentiginous Nevus. Cureus 17(","cbCaitjIi035wxI2","https://ap.wps.com/l/cbCaitjIi035wxI2","pdf",2594987,"English","# Abstract\n# Introduction\n# Case Presentation\n# How to cite this article\n# Discussion","[{\"question\":\"What is speckled lentiginous nevus (SLN) and how is it typically described?\",\"answer\":\"SLN (nevus spilus) is a common benign melanocytic neoplasm that usually presents as a small café-au-lait–colored “speckled” patch with numerous darkly pigmented macules or papules.\"},{\"question\":\"How was the diagnosis confirmed in this patient?\",\"answer\":\"A shave biopsy was performed, and hematoxylin and eosin histopathology showed benign compound features with a lentiginous junctional component and minimal atypia; PRAME immunohistochemistry was negative.\"},{\"question\":\"Why is acral SLN clinically notable?\",\"answer\":\"Acral SLN is extremely rare in the literature, making the reported occurrence on the sole of the foot novel. The case highlights diagnostic considerations for special-site lesions.\"}]","Acral Speckled Lentiginous Nevus - open access case report | PDF",1790754732,13]