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This case report details a 2-month-old female who developed grade 3 SGS following intubation and mechanical ventilation for acute respiratory failure due to pertussis pneumonia. Flexible laryngoscopy and imaging confirmed severe stenosis, and treatment used a multimodal endoscopic strategy combining holmium laser ablation, balloon dilation, and cryotherapy. Post-procedure airway improvement allowed oxygen weaning by day 5, and follow-up at 1 month showed sustained patency without restenosis.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/acquired-subglottic-stenosis-in-a-2-month-old-infant-after-prolonged-intubation-associated-with-pertussis-pneumonia-case-report/416633/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/acquired-subglottic-stenosis-in-a-2-month-old-infant-after-prolonged-intubation-associated-with-pertussis-pneumonia-case-report/416633.png","ImageObject",300,407,{"name":92,"@type":93},"Blitz","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-01","2026-09-28",true,{"@type":102,"interactionType":103,"userInteractionCount":39},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What caused the subglottic stenosis in the 2-month-old infant?","Question",{"text":112,"@type":113},"The infant developed acquired subglottic stenosis after intubation and mechanical ventilation for acute respiratory failure caused by pertussis pneumonia.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How was the severity of SGS determined?",{"text":117,"@type":113},"Flexible laryngoscopy and diagnostic imaging confirmed grade 3 SGS using the Cotton-Myer classification.",{"name":119,"@type":110,"acceptedAnswer":120},"What treatment approach was used and what were the outcomes?",{"text":121,"@type":113},"A multimodal endoscopic approach was used: holmium laser ablation to remove fibrotic tissue, balloon dilation to expand the stenotic segment, and cryotherapy to reduce scar formation. Improvement was noted immediately after the procedure, oxygen was tapered by day 5, and follow-up at 1 month showed sustained airway patency without restenosis.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},416633,1790695985,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":39,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":24,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144,"preview_page_count":4},24464137899374,"https://us-avatar.wpscdn.com/davatar_3d24733baf745e90a7e4bdd5f77d97b2","e-ISSN 1941-5923  \n© Am J Case Rep, 2025; 26: e948709 DOI: 10. 12659/AJCR.948709  \nReceived: 2025.02.27  \nAccepted: 2025.10.01  \nAvailable online: 2025.11.05  \nPublished: 2025.12.14  \nAuthors’ Contribution: Study Design A  \nData Collection B Statistical Analysis C Data Interpretation D Manuscript Preparation E Literature Search F Funds Collection G  \nABCDEF  \nBCD  \nABF  \nBCD  \nABCD  \nBDFG  \nCorresponding Authors:  \nFinancial support: Conflict of interest:  \nAcquired Subglottic Stenosis in a 2-Month-Old Infant After Prolonged Intubation Associated With Pertussis Pneumonia: A Case Report  \nYun-Gai Cheng Xiao-Fen Tao Dan Xu  \nXue-Jing Li Lei Wu  \nXi-Ling Wu  \nDepartment of Pulmonology, The Children’s Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, Zhejiang, PR China  \nWu Lei, e-mail: [Zjuent@zju.edu.cn](Zjuent@zju.edu.cn), Wu Xi-Ling, [e-mail:](e-mail: wuxiling@zju.edu.cn)[ wuxiling@zju.edu.cn](e-mail: wuxiling@zju.edu.cn)  \nThis work was supported by the Zhejiang Provincial Natural Science Foundation (Grant/Award Number: LY21H010002) None declared  \nPatient: Female, 2-month-old  \nFinal Diagnosis: Severe acquired SGS (Grade 3)  \nSymptoms: Respiratory distress and stridor  \nClinical Procedure: —  \nSpecialty: Pulmonology  \nObjective: Rare disease  \nBackground: Subglottic stenosis (SGS) is a life-threatening airway narrowing often acquired after prolonged intubation in infants. Although severe cases have historically required open surgery, emerging endoscopic techniques such as laser therapy, balloon dilation, and cryotherapy provide less invasive alternatives with promising outcomes. This case report describes a 2-month-old female infant who developed subglottic stenosis after intubation and mechanical ventilation for acute respiratory failure due to pertussis pneumonia.  \nCase Report: A 2-month-old female infant with a history of pertussis pneumonia requiring 10 days of intubation presented with respiratory distress and stridor. Diagnostic imaging and flexible laryngoscopy confirmed grade 3 SGS (Cotton-Myer classification). She underwent a multimodal endoscopic approach, including holmium laser ablation (0.5-1.0 J/pulse) for fibrotic tissue removal, balloon dilation (6 mm, 14 atmospheres) to expand the stenotic segment, and cryotherapy (-70°C) to minimize scar formation. Immediate post-procedural improvement was observed, and oxygen was gradually tapered by day 5. Follow-up fiber laryngoscopy at 1 month demonstrated sustained airway patency without restenosis.  \nConclusions: This case supports the efficacy of combined endoscopic modalities for severe pediatric SGS, offering advantages over open surgery, including reduced morbidity and faster recovery. Long-term studies are needed to confirm durability, particularly for high-grade stenosis. Standardized protocols for laser settings, balloon sizing, and cryotherapy duration should be established to optimize outcomes.  \nKeywords: Subglottic Stenosis • Infant • Intubation • Intratracheal • Case Report  \nFull-text PDF: [https://www.amjcaserep.com/abstract/index/idArt/948709](https://www.amjcaserep.com/abstract/index/idArt/948709)  \n1628  —  3  23  \nPublisher’s note: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher  \nThis work is licensed under Creative Common AttributionNonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)  \ne948709-1  \nIndexed in: [PMC] [PubMed] [Emerging Sources Citation Index (ESCI)][Web of Science by Clarivate]  \n[Cheng Y.-G. et](Cheng Y.-G. et) al:  \nAcquired SGS in an infant after prolonged intubation © Am J Case Rep, 2025; 26: e948709  \nIntroduction  \nPertussis (whooping cough) remains a major glob","cbCaij0GfNAaxgkG","https://ap.wps.com/l/cbCaij0GfNAaxgkG","pdf",862031,"English","# Introduction\n# Case Report\n# Conclusions\n# Keywords","[{\"question\":\"What caused the subglottic stenosis in the 2-month-old infant?\",\"answer\":\"The infant developed acquired subglottic stenosis after intubation and mechanical ventilation for acute respiratory failure caused by pertussis pneumonia.\"},{\"question\":\"How was the severity of SGS determined?\",\"answer\":\"Flexible laryngoscopy and diagnostic imaging confirmed grade 3 SGS using the Cotton-Myer classification.\"},{\"question\":\"What treatment approach was used and what were the outcomes?\",\"answer\":\"A multimodal endoscopic approach was used: holmium laser ablation to remove fibrotic tissue, balloon dilation to expand the stenotic segment, and cryotherapy to reduce scar formation. Improvement was noted immediately after the procedure, oxygen was tapered by day 5, and follow-up at 1 month showed sustained airway patency without restenosis.\"}]","Acquired Subglottic Stenosis in a 2-Month-Old Infant After Prolonged Intubation Associated With Pertussis Pneumonia - Case Report | PDF",1790606114,13]