[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-430368-105":3,"detail-sidebar-cat-0-en-105":81,"doc-detail-430368-en":131},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","acquired-gray-platelet-syndrome-as-a-rare-hematologic-complication-in-a-case-of-jak2-positive-post-polycythemia-vera-myelofibrosis-case-report","Acquired Gray platelet syndrome as a rare hematologic complication in a case of JAK2-positive post polycythemia Vera myelofibrosis - Case report","","Case report on a 70-year-old male with a history of JAK2 mutation-positive post-polycythemia vera myelofibrosis and an acquired bleeding disorder. Platelet studies showed platelet dysfunction, and platelet electron microscopy confirmed acquired gray platelet syndrome due to an abnormality in platelet alpha-granules. Treatment with desmopressin (DDAVP) improved platelet function. The patient underwent central venous catheter placement and a hematopoietic stem cell transplant without bleeding complications, with follow-up demonstrating normalized platelet function testing and resolution of the acquired GPS.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/acquired-gray-platelet-syndrome-as-a-rare-hematologic-complication-in-a-case-of-jak2-positive-post-polycythemia-vera-myelofibrosis-case-report/430368/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/acquired-gray-platelet-syndrome-as-a-rare-hematologic-complication-in-a-case-of-jak2-positive-post-polycythemia-vera-myelofibrosis-case-report/430368.png","ImageObject",300,407,{"name":42,"@type":43},"Margaret","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-11-06","2026-09-29",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",11,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What underlying condition did the patient have before developing the bleeding disorder?","Question",{"text":63,"@type":64},"The patient had JAK2 mutation-positive post-polycythemia vera myelofibrosis and then developed an acquired bleeding disorder related to platelet dysfunction.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"How was acquired gray platelet syndrome confirmed in the case?",{"text":68,"@type":64},"Platelet dysfunction testing was abnormal, and platelet electron microscopy demonstrated acquired gray platelet syndrome.",{"name":70,"@type":61,"acceptedAnswer":71},"What treatments improved platelet function and what was the transplant outcome?",{"text":72,"@type":64},"Platelet function improved after desmopressin administration. The patient successfully underwent central venous catheter placement and a hematopoietic stem cell transplant without bleeding complications, with follow-up showing normalization and resolution of the acquired GPS.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},430368,1790816885,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,110,115,120,123,127],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":107,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":108,"slug":109},7,40,"healthcare",{"id":111,"doc_module":4,"doc_module_name":25,"category_name":112,"show_sort_weight":113,"slug":114},8,"Research & Report",30,"research-report",{"id":116,"doc_module":4,"doc_module_name":25,"category_name":117,"show_sort_weight":118,"slug":119},9,"Religion & Spirituality",20,"religion-spirituality",{"id":118,"doc_module":4,"doc_module_name":25,"category_name":121,"show_sort_weight":118,"slug":122},"World Cup","world-cup",{"id":124,"doc_module":4,"doc_module_name":25,"category_name":125,"show_sort_weight":124,"slug":126},10,"Lifestyle","lifestyle",{"id":128,"doc_module":4,"doc_module_name":25,"category_name":129,"show_sort_weight":97,"slug":130},19,"General","general",{"code":4,"msg":82,"data":132},{"doc_id":79,"user_id":133,"nickname":42,"user_avatar":134,"doc_module":4,"category_id":107,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":33,"language":140,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":12,"update_tm":144,"read_time":124,"preview_page_count":4},137451207643,"https://ap-avatar.wpscdn.com/davatar_3d24733baf745e90a7e4bdd5f77d97b2","Annals of Hematology (2025) 104:6447–6450  \n[https://doi.org/10.1007/s00277-025-06587-5](https://doi.org/10.1007/s00277-025-06587-5)  \nCASE REPORT  \nAcquired Gray platelet syndrome as a rare hematologic complication in a case of JAK2-positive post polycythemia Vera myelofibrosis  \nAishwarya Pradeep1 · Ayo S. Falade2 · Juliana Perez Botero3 · Dong C. Chen3 · Rajiv K. Pruthi2,3 · Aasiya Matin2  \nReceived: 25 June 2025 / Accepted: 16 August 2025 / Published online: 2 October 2025 © The Author(s) 2025  \nAbstract  \nWe report the case of a 70-year-old male with a history of JAK2 mutation-positive post-polycythemia vera myelofibrosis and an acquired bleeding disorder. Investigations revealed platelet dysfunction, and platelet electron microscopy demonstrated an acquired gray platelet syndrome. His platelet function improved with desmopressin administration, and he successfully underwent a central venous catheter placement and hematopoietic stem cell transplant with no bleeding complications. Follow up testing demonstrated normalization of platelet function testing and resolution of his acquired gray platelet syndrome.  \nKeywords Acquired gray platelet syndrome · Case report · Bleeding disorder · Hematopoietic stem cell transplant · Platelet dysfunction  \nIntroduction  \nInherited plasmatic bleeding disorders, in general, are considered rare bleeding disorders [1] and inherited platelet disorders (IPD) are considered ultra-rare bleeding disorders [2] . IPDs can be classified based on platelet number, function, size, and abnormalities in platelet granule content [2]. Gray platelet syndrome (GPS), an IPD, is characterized by a variable bleeding phenotype, large platelets, and an absence or severe deficiency of platelet al.pha granules [3] . Inheritance is typically autosomal recessive, but cohorts of autosomal dominant transmission have been described [3] . Clinical management of bleeding includes platelet transfusion or intravenous desmopressin (DDAVP) [3] .  \nAcquired platelet function defects are likely more common than IPD and have a wide variety of underlying etiologies [4] . Acquired GPS is extremely rare with only two  \n􀀍 Aishwarya Pradeep MD [pradeep.aishwarya@mayo.edu](pradeep.aishwarya@mayo.edu)  \n1 Department of Internal Medicine, Mayo Clinic, 200 First St SW, Rochester, MN, USA  \n2 Division of Hematology, Department of Internal Medicine, Mayo Clinic, Rochester, MN, USA  \n3 Division of Hematopathology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA  \nreports in the literature, both associated with an underlying myeloproliferative neoplasm (MPN) [5, 6] . In the first report, the patient presented with recurrent post-operative bleeding, investigation of which led to the diagnosis of MPN and acquired GPS. Allogeneic hematopoietic stem cell transplant (allo-HSCT) led to resolution of his platelet defect [5] . In the second report, a patient with known MPN experienced hemorrhage after paracentesis, further investigation of which led to the diagnosis of acquired GPS. He did not survive allo-HSCT. In both cases, long-term outcomes are not available [6] . Herein, we report long term outcomes ofa case of JAK2 mutation-positive polycythemia vera (JAK2-PV), hemostatic management of central venous access device placement and management and long-term outcomes ofallo-HSCT.  \nCase presentation  \nA 70-year-old white male with a past medical history of JAK2-PV progressing to myelofibrosis was referred for evaluation of abnormal bleeding, prior to placement of a central venous access device for an allo-HSCT. The patient had no prior personal or family history of abnormal bleeding in childhood or as an adult and had undergone right total hip arthroplasty, inguinal hernia repair, open splenectomy and right total knee arthroplasty with no excessive bleeding  \nepisodes. Written informed consent was obtained by the patient for publication. The patient was diagnosed with JAK2-PV 12 years prior when his hematocrit was","cbCaitKrDjfmdxe1","https://ap.wps.com/l/cbCaitKrDjfmdxe1","pdf",1008728,"English","# Abstract\n# Introduction\n# Case presentation","[{\"question\":\"What underlying condition did the patient have before developing the bleeding disorder?\",\"answer\":\"The patient had JAK2 mutation-positive post-polycythemia vera myelofibrosis and then developed an acquired bleeding disorder related to platelet dysfunction.\"},{\"question\":\"How was acquired gray platelet syndrome confirmed in the case?\",\"answer\":\"Platelet dysfunction testing was abnormal, and platelet electron microscopy demonstrated acquired gray platelet syndrome.\"},{\"question\":\"What treatments improved platelet function and what was the transplant outcome?\",\"answer\":\"Platelet function improved after desmopressin administration. The patient successfully underwent central venous catheter placement and a hematopoietic stem cell transplant without bleeding complications, with follow-up showing normalization and resolution of the acquired GPS.\"}]","Acquired Gray platelet syndrome as a rare hematologic complication in a case of JAK2-positive post polycythemia Vera myelofibrosis - Case report | PDF",1790652624]