[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-detail-31470":3,"doc-seo-31470":27},{"code":4,"msg":5,"data":6},0,"success",{"doc_id":7,"user_id":8,"nickname":9,"user_avatar":10,"doc_module":4,"category_id":11,"category_name":12,"doc_title":13,"doc_description":14,"file_id":15,"file_url":16,"file_type":17,"file_size":18,"view_count":4,"is_deleted":4,"is_public":19,"is_downloadable":19,"audit_status":19,"page_count":20,"language":21,"language_code":22,"table_of_contents":23,"faqs":24,"seo_title":13,"seo_description":14,"update_tm":25,"read_time":26},31470,962075006959,"Anda","https://ap-avatar.wpscdn.com/avatar/e0002397efbe92a78e?_k=1776741047341049297",7,"Healthcare","ACOG Practice Bulletin 53: Diagnosis and Treatment of Gestational Trophoblastic Disease","ACOG Practice Bulletin No. 53 provides clinical management guidelines for gestational trophoblastic disease, a spectrum of placental disorders that includes complete and partial hydatidiform moles, invasive moles, gestational choriocarcinomas, and placental site trophoblastic tumors. The bulletin summarizes current evidence for diagnosis, staging, and management, emphasizing how sensitive quantitative β-hCG assays and modern chemotherapy enable cure for most malignant cases while preserving reproductive function. It also details incidence estimates, typical presentation patterns, and the need for referral when initial therapy fails or when choriocarcinoma is diagnosed.","cbCaifxadeN33c7d","https://ap.wps.com/l/cbCaifxadeN33c7d","pdf",939229,1,13,"English","en","# Diagnosis and Treatment of Gestational Trophoblastic Disease\n## Background and Incidence\n## Hydatidiform Mole\n### Classification\n### Diagnosis","[{\"question\":\"What conditions are included in gestational trophoblastic disease?\",\"answer\":\"Gestational trophoblastic disease covers interrelated placental conditions, including complete and partial hydatidiform moles, invasive moles, gestational choriocarcinomas, and placental site trophoblastic tumors.\"},{\"question\":\"How have diagnostic and treatment advances changed outcomes?\",\"answer\":\"Sensitive quantitative assays for β-hCG and current chemotherapy approaches allow most women with malignant gestational trophoblastic disease to be cured while preserving reproductive function.\"},{\"question\":\"What clinical features suggest hydatidiform mole in the first trimester?\",\"answer\":\"Common signs include abnormal bleeding, uterine enlargement beyond expected gestational age, absent fetal heart tones, cystic ovarian enlargement, hyperemesis gravidarum, and an abnormally high hCG level for gestational age.\"}]",1779570042,33,{"code":4,"msg":28,"data":29},"ok",{"site_id":30,"language":22,"slug":31,"title":13,"keywords":32,"description":14,"schema_data":33,"social_meta":84,"head_meta":86,"extra_data":88,"updated_unix":25},105,"acog-practice-bulletin-53-diagnosis-and-treatment-of-gestational-trophoblastic-disease","",{"@graph":34,"@context":83},[35,52,66],{"@type":36,"itemListElement":37},"BreadcrumbList",[38,42,46,49],{"item":39,"name":40,"@type":41,"position":19},"https://docshare.wps.com","Home","ListItem",{"item":43,"name":44,"@type":41,"position":45},"https://docshare.wps.com/document/","Document",2,{"item":47,"name":12,"@type":41,"position":48},"https://docshare.wps.com/document/healthcare/",3,{"item":50,"name":13,"@type":41,"position":51},"https://docshare.wps.com/document/acog-practice-bulletin-53-diagnosis-and-treatment-of-gestational-trophoblastic-disease/31470/",4,{"url":50,"name":13,"@type":53,"author":54,"headline":13,"publisher":56,"fileFormat":59,"description":14,"dateModified":60,"datePublished":60,"encodingFormat":59,"isAccessibleForFree":61,"interactionStatistic":62},"DigitalDocument",{"name":9,"@type":55},"Person",{"url":39,"name":57,"@type":58},"DocShare","Organization","application/pdf","2026-05-23",true,{"@type":63,"interactionType":64,"userInteractionCount":4},"InteractionCounter",{"@type":65},"ViewAction",{"@type":67,"mainEntity":68},"FAQPage",[69,75,79],{"name":70,"@type":71,"acceptedAnswer":72},"What conditions are included in gestational trophoblastic disease?","Question",{"text":73,"@type":74},"Gestational trophoblastic disease covers interrelated placental conditions, including complete and partial hydatidiform moles, invasive moles, gestational choriocarcinomas, and placental site trophoblastic tumors.","Answer",{"name":76,"@type":71,"acceptedAnswer":77},"How have diagnostic and treatment advances changed outcomes?",{"text":78,"@type":74},"Sensitive quantitative assays for β-hCG and current chemotherapy approaches allow most women with malignant gestational trophoblastic disease to be cured while preserving reproductive function.",{"name":80,"@type":71,"acceptedAnswer":81},"What clinical features suggest hydatidiform mole in the first trimester?",{"text":82,"@type":74},"Common signs include abnormal bleeding, uterine enlargement beyond expected gestational age, absent fetal heart tones, cystic ovarian enlargement, hyperemesis gravidarum, and an abnormally high hCG level for gestational age.","https://schema.org",{"og:url":50,"og:type":85,"og:title":13,"og:site_name":57,"og:description":14},"article",{"robots":87,"canonical":50},"index,follow",{"doc_id":7,"site_id":30}]