[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-423259-105":59,"doc-detail-423259-en":131},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":124,"head_meta":126,"extra_data":128,"updated_unix":130},105,"en","accelerated-phenotypical-aging-in-midlife-is-associated-with-long-term-cognitive-decline","Accelerated Phenotypical Aging in Midlife is Associated with Long-Term Cognitive Decline","","PhenoAge, a multi-system biomarker derived from routine blood tests, was used to assess whether biological aging in midlife is advanced relative to chronological age. In a longitudinal cohort (N=2,630), accelerated PhenoAge predicted worse Trail-making Test B performance at baseline and a faster 10-year cognitive decline, overall and in men. Additional follow-up is needed to determine whether PhenoAge will predict later cognitive impairment and dementia for early identification and targeted interventions.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/accelerated-phenotypical-aging-in-midlife-is-associated-with-long-term-cognitive-decline/423259/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/accelerated-phenotypical-aging-in-midlife-is-associated-with-long-term-cognitive-decline/423259.png","ImageObject",300,407,{"name":92,"@type":93},"Emma Wilson","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-30","2026-09-28",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",11,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What biomarker was used to measure accelerated aging in midlife?","Question",{"text":113,"@type":114},"The study used PhenoAge, calculated from easily obtained common clinical blood tests, and focused on accelerated PhenoAge (PhenoAgeAccel) relative to chronological age.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"How did accelerated PhenoAge relate to cognitive performance over time?",{"text":118,"@type":114},"Higher PhenoAgeAccel was associated with worse Trail-making Test B performance at baseline and a faster decline in Trail-making Test B over 10 years.",{"name":120,"@type":111,"acceptedAnswer":121},"What follow-up is suggested for future research and practical use?",{"text":122,"@type":114},"Longer follow-up is needed to determine whether PhenoAge can predict later cognitive impairment; if confirmed, it could support early identification and inform targeted interventions.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},423259,1790795432,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":14,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":24,"preview_page_count":4},3848291630094,"https://eur-avatar.wpscdn.com/davatar_085a072bc5b1113ac321206ff7593b45","64 Innovation in Aging, 2025, Vol. 9, No. S2  \nAbstract citation ID: igaf122.212  \nACCELERATED PHENOTYPICAL AGING IN MIDLIFE IS ASSOCIATED WITH LONG-TERM  \nCOGNITIVE DECLINE  \nNatascha Merten1, Mary Ryan Baumann1, Richard Chappell1, Yanjun Chen1, Lindsay Clark1, Sterling Johnson1, James Pankow2, and Art Walaszek1, 1. University of WisconsinMadison, Madison, Wisconsin, United States, 2. University of Minnesota, Minneapolis, Minnesota, United States  \nPhenoAge, a multi-system biomarker uses easily-obtained common clinical blood tests and determines whether a person is younger or older on a biological and physiological level than expected by chronological age. Higher PhenoAge is associated with increased risk of disability, age-related morbidities and all-cause mortality. Its associations with early cognitive changes in midlife are less understood. The aim of this study was to determine whether accelerated PhenoAge in midlife was associated with 10-year cognitive changes in middle-aged to older adults. This longitudinal study is based on N =2,630 (54% women;mean age 50years) Beaver Dam Offspring Study participants. We measured baseline blood-based clinical markers necessary for calculation of accelerated PhenoAge (PhenoAgeAccel). We tested Trail-making Test B (TMT-B) performance at baseline, 5-year and 10-year follow-up.We used linear mixed-effects model with PhenoAgeAccelas predictor and TMT-B time as outcome, adjusting for random intercepts, education and sex. Models were repeated sex-stratified. With every additional year older in PhenoAge compared to chronological age at baseline, participants performed worse on the TMT-B at baseline [overall:0 .60 seconds slower, 95% Confidence Interval (0 .29,0 .91); women: 0.34(-0 .05,0 .72); men: 0.91(0.41,1.42)] and had a faster decline inTMT-B over 10-years [overall:0.94seconds slower (0.58,1.29); women: 0.51(0.08,0.95); men: 1.48(0.90,2.07)]. Accelerated PhenoAge in midlife was associated with 10-year cognitive decline, overall and in men. Longer follow-up will be needed to determine whether PhenoAge might be predictive of cognitive impairment later in life. If confirmed, PhenoAge could become a cost-effective marker of cognitive  \nInnovation in Aging, 2025, Vol. 9, No. S2 65  \ndecline and dementia and help identify at-risk individuals early and inform targeted interventions.","cbCaivHuPbryzqDp","https://ap.wps.com/l/cbCaivHuPbryzqDp","pdf",216901,"English","# Abstract\n## Study aim and design\n## Biomarker and measurements\n## Statistical analysis\n## Key findings\n## Implications","[{\"question\":\"What biomarker was used to measure accelerated aging in midlife?\",\"answer\":\"The study used PhenoAge, calculated from easily obtained common clinical blood tests, and focused on accelerated PhenoAge (PhenoAgeAccel) relative to chronological age.\"},{\"question\":\"How did accelerated PhenoAge relate to cognitive performance over time?\",\"answer\":\"Higher PhenoAgeAccel was associated with worse Trail-making Test B performance at baseline and a faster decline in Trail-making Test B over 10 years.\"},{\"question\":\"What follow-up is suggested for future research and practical use?\",\"answer\":\"Longer follow-up is needed to determine whether PhenoAge can predict later cognitive impairment; if confirmed, it could support early identification and inform targeted interventions.\"}]","Accelerated Phenotypical Aging in Midlife is Associated with Long-Term Cognitive Decline | PDF",1790630610]