[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-427406-105":3,"detail-sidebar-cat-0-en-105":81,"doc-detail-427406-en":130},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","accelerated-molecular-aging-in-neighborhood-poverty-a-racialethnic-comparison","ACCELERATED MOLECULAR AGING IN NEIGHBORHOOD POVERTY - A RACIAL/ETHNIC COMPARISON","","In the US, racial/ethnic health disparities are undeniable and partially driven by residence in low socioeconomic status (SES) neighborhoods. This study tested whether neighborhood poverty is linked to accelerated epigenetic aging measured by the Horvath, Hannum, PhenoAge, and GrimAge clocks, and whether associations vary by race/ethnicity. Using 3,790 older adults from the 2016 Health and Retirement Study with census-tract poverty rates (2012–2016), results showed higher poverty predicted accelerated PhenoAge and GrimAge, but after smoking adjustment only GrimAge remained. Interaction analyses indicated stronger associations for non-Hispanic White participants, which disappeared after accounting for smoking, highlighting the role of economic investment and further research.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/research-report/","Research & 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does the study test about neighborhood poverty and aging?","Question",{"text":63,"@type":64},"It tests whether greater neighborhood poverty relates to accelerated epigenetic aging on multiple epigenetic clocks and whether these relationships differ by race/ethnicity.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"Which epigenetic clocks showed associations with neighborhood poverty?",{"text":68,"@type":64},"Higher-poverty neighborhoods were associated with accelerated PhenoAge and GrimAge, but after considering smoking status only the GrimAge association remained.",{"name":70,"@type":61,"acceptedAnswer":71},"How did race/ethnicity affect the poverty–aging relationship?",{"text":72,"@type":64},"Poverty showed a stronger association with accelerated GrimAge among non-Hispanic White participants, but that racial/ethnic difference was completely reduced after accounting for smoking.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},427406,1790795435,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,111,114,119,122,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & 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resilience to, or embody greater harmful and cumulative outcomes from, such neighborhoods. The present study tested the hypothesis that greater neighborhood poverty would relate to accelerated epigenetic aging on the Horvath, Hannum, PhenoAge, and GrimAge clocks, and that these associations would differ in strength by race/ethnicity. A national sample of  \n3,790 older non-Hispanic White, non-Hispanic Black, and Hispanic participants from the 2016 wave of the Health and Retirement Study and census tract poverty rates from the 2012-2016 American Community Survey were used to test these questions. Results of weighted linear regressions suggested that living in higher poverty neighborhoods was associated with accelerated PhenoAge and GrimAge (not Hannum or Horvath), adjusting for age, sex, and educational. After further considering smoking status, however, only the association with GrimAge remained. Investigating interactions with race/ethnicity suggested that poverty was more strongly associated with accelerated GrimAge among non-Hispanic White participants, but this racial/ethnic difference was completely reduced after considering smoking. These results further support the need for economic investment in low SES neighborhoods and encourage more research to determine the social and physical resources needed in such neighborhoods to attenuate accelerated epigenetic aging.  \nSESSION 7315 (POSTER)   \nBIOLOGY OF AGING II  \nAbstract citation ID: igaf122.2876  \nACCELERATED MOLECULAR AGING IN  \nNEIGHBORHOOD POVERTY: A RACIAL/ETHNIC  \nCOMPARISON  \nJennifer Robinette1, and Jennifer Smith2, 1. Chapman University, Orange, California, United States, 2. University of Michigan, Ann Arbor, Michigan, United States  \nIn the US, racial/ethnic health disparities are undeniable and partially stem from residing in low SES neighborhoods.  \nAssociations between neighborhood SES and health may have some underlying molecular mechanisms reflected in the epigenome. Yet, neighborhood characteristics are not always experienced the same way for all residents, and questions remain","cbCaicZyXlLLRHtD","https://ap.wps.com/l/cbCaicZyXlLLRHtD","pdf",767726,"English","# Accelerated molecular aging in neighborhood poverty: a racial/ethnic comparison\n## Study hypothesis and measures\n## Data and analytic approach\n## Main findings and smoking adjustment\n## Race/ethnicity interactions and implications","[{\"question\":\"What hypothesis does the study test about neighborhood poverty and aging?\",\"answer\":\"It tests whether greater neighborhood poverty relates to accelerated epigenetic aging on multiple epigenetic clocks and whether these relationships differ by race/ethnicity.\"},{\"question\":\"Which epigenetic clocks showed associations with neighborhood poverty?\",\"answer\":\"Higher-poverty neighborhoods were associated with accelerated PhenoAge and GrimAge, but after considering smoking status only the GrimAge association remained.\"},{\"question\":\"How did race/ethnicity affect the poverty–aging relationship?\",\"answer\":\"Poverty showed a stronger association with accelerated GrimAge among non-Hispanic White participants, but that racial/ethnic difference was completely reduced after accounting for smoking.\"}]","ACCELERATED MOLECULAR AGING IN NEIGHBORHOOD POVERTY - A RACIAL/ETHNIC COMPARISON | PDF",1790643757]