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This observational study quantified DNA methylation–based epigenetic age in survivors at least three months post-treatment and compared cancer treatment intensity with epigenetic age and aging pace versus similarly aged healthy comparators. Epigenetic age acceleration and faster aging pace were higher in survivors, especially with reduced muscle mass.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/accelerated-epigenetic-aging-and-myopenia-in-young-adult-cancer-survivors/383723/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/accelerated-epigenetic-aging-and-myopenia-in-young-adult-cancer-survivors/383723.png","ImageObject",300,407,{"name":92,"@type":93},"Rhys","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-09-27","2026-09-24",true,{"@type":102,"interactionType":103,"userInteractionCount":14},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is the main purpose of measuring epigenetic aging in young adult cancer survivors?","Question",{"text":112,"@type":113},"To identify survivors at higher risk by detecting accelerated biological aging before functional declines and morbidities appear, and to help clarify mechanisms behind accelerated aging.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How was epigenetic age measured and compared in the study?",{"text":117,"@type":113},"DNA methylation–based epigenetic age was measured cross-sectionally using epigenetic clocks in survivors and similarly aged healthy comparators, and results were compared with treatment and treatment intensity.",{"name":119,"@type":110,"acceptedAnswer":120},"What did the study find about epigenetic age and pace of aging in survivors?",{"text":121,"@type":113},"Compared with noncancer peers, survivors showed greater epigenetic age acceleration and a faster pace of aging, evident particularly in the early post-therapy period.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},383723,1790539247,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":14,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":41},687207024643,"https://ap-avatar.wpscdn.com/davatar_3d24733baf745e90a7e4bdd5f77d97b2","DOI: 10. 1002/cam4 .5908  \nRESEAR CH ARTICLE  \nAccelerated epigenetic aging and myopenia in young adult cancer survivors  \nStephanie C. Gehle1  | Daniel Kleissler2 | Hillary Heiling3 | Allison Deal2 |  \nZongli Xu4 | Vanessa L. Ayer Miller5 | Jack A. Taylor4 | Andrew B. Smitherman1,2   \n1Department of Pediatrics UNC School of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA  \n2Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA  \n3Department of Biostatistics at the Gillings School of Global Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA 4Epidemiology Branch, National Institute of Environmental Health Sciences, Durham, North Carolina, USA  \n5College of Pharmacy and Health Sciences, Campbell University, Buies Creek, North Carolina, USA  \nCorrespondence  \nAndrew B. Smitherman, Campus Box 7236, 170 Manning Drive, 1185APhysician's Office Building, Chapel Hill, NC 27599, USA.  \nEmail: andrew_smitherman@med. [unc.edu](unc.edu)  \nFunding information  \nHyundai Hope On Wheels; National Institute of Environmental Health Sciences, Grant/Award Number:  \nZ01ES04903 and Z01ES049032  \nAbstract  \nBackground: Young adult cancer survivors experience early aging-related morbidities and mortality. Biological aging biomarkers may identify at-risk survivorsand increase our understanding of mechanisms underlying this accelerated aging. Methods: Using an observational study design, we cross-sectionally measured DNA methylation-based epigenetic age in young adult cancer survivors at a tertiary, academic state cancer hospital. Participants were a convenience sample of consecutively enrolled survivors of childhood, adolescent, and young adult cancers treated with either an anthracycline or alkylating agent, and who were at least 3 months post-treatment. Similarly aged healthy comparators were consecutively enrolled. Cancer treatment and treatment intensity were compared to DNA methylation-based epigenetic age and pace of aging.  \nResults: Sixty survivors (58 completing assessments, mean age 20.5years, range 18–29) and 27 comparators (mean age 20 years, range 17–29) underwent DNA methylation measurement. Survivors were predominantly female (62%) and white (60%) and averaged nearly 6 years post-treatment (range 0.2–25years) . Both epigenetic age (AgeAccelGrim: 1.5 vs. −2.4, p\u003C0.0001; AgeAccelPheno 2.3 vs. −3.8, p = 0.0013) and pace of aging (DunedinPACE 0.99 vs. 0.83, p \u003C0.0001) were greater in survivors versus comparators. In case–case adjusted analysis, compared to survivors with normal muscle mass, myopenic survivors had higher AgeAccelGrim (2.2 years, 95% CI 0.02–4.33, p = 0.02), AgeAccelPheno (6.2 years, 2.36–10.09, p \u003C0.001), and DunedinPACE (0.11, 0.05–0.17, p \u003C0.001) . Conclusions: Epigenetic age is older and pace of aging is faster in young adult cancer survivors compared to noncancer peers, which is evident in the early posttherapy period. Survivors with physiological impairment demonstrate greater epigenetic age advancement. Measures of epigenetic age may identify young adult survivors at higher risk for poor functional and health outcomes.  \nKEYWORDS  \naging, cancer survivorship, DNA methylation, epigenetic age  \nThis is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.  \n© 2023 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.  \n1 | INTRODUCTION  \nAdvancements in cancer and supportive therapies have led to a growing population of young adult survivors1,2 with more than 700,000 survivors now living in the United States.3 The majority of young adult survivors experience significant impairments in health, quality of life, and lifespan with increased secondary cancers, cardiovascular disease, and endocrinopathies.4-15 The premature onset of agi","cbCaii5tkQ4PmLrt","https://ap.wps.com/l/cbCaii5tkQ4PmLrt","pdf",1342429,12,"English","# Introduction\n## Epigenetic age and biological aging biomarkers\n# Abstract\n## Background\n## Methods\n## Results\n## Conclusions","[{\"question\":\"What is the main purpose of measuring epigenetic aging in young adult cancer survivors?\",\"answer\":\"To identify survivors at higher risk by detecting accelerated biological aging before functional declines and morbidities appear, and to help clarify mechanisms behind accelerated aging.\"},{\"question\":\"How was epigenetic age measured and compared in the study?\",\"answer\":\"DNA methylation–based epigenetic age was measured cross-sectionally using epigenetic clocks in survivors and similarly aged healthy comparators, and results were compared with treatment and treatment intensity.\"},{\"question\":\"What did the study find about epigenetic age and pace of aging in survivors?\",\"answer\":\"Compared with noncancer peers, survivors showed greater epigenetic age acceleration and a faster pace of aging, evident particularly in the early post-therapy period.\"}]","Accelerated epigenetic aging and myopenia in young adult cancer survivors | PDF",1790258899]