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The preface outlines the workshop aim to present new research on rare bradykinin-mediated angioedema disorders, including hereditary or acquired C1-inhibitor deficiency and HAE with normal C1-inhibitor. It highlights record numbers of oral and poster presentations, keynote lectures on mRNA vaccine development, ITIH4 regulation, antibody-based therapies, genetic diagnosis, and clinical considerations for preventive treatments, plus consensus-building and award recognition.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/abstracts-of-the-14th-c1-inhibitor-deficiency-and-angioedema-workshop-part-14-opening-and-keynote-highlights/422341/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/abstracts-of-the-14th-c1-inhibitor-deficiency-and-angioedema-workshop-part-14-opening-and-keynote-highlights/422341.png","ImageObject",300,407,{"name":92,"@type":93},"Alexandar","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-05","2026-09-28",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",13,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What is the main purpose of the 14th C1-inhibitor Deficiency and Angioedema Workshop?","Question",{"text":113,"@type":114},"To present new research findings related to rare bradykinin-mediated angioedema disorders, including hereditary and acquired C1-inhibitor deficiency and HAE with normal C1-inhibitor levels.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"How are HAE with normal C1-inhibitor levels diagnosed according to the preface?",{"text":118,"@type":114},"Diagnosis is confirmed by identifying a known pathogenic variant in one of the genes associated with the disease, and genetic results must be interpreted and applied accordingly.",{"name":120,"@type":111,"acceptedAnswer":121},"What are the key themes covered by invited lectures?",{"text":122,"@type":114},"Topics include mRNA vaccine development, ITIH4 and its potential regulation of plasma proteolytic systems, monoclonal antibody therapies, and clinical considerations for preventive therapies from trials.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},422341,1790801804,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":140,"language":141,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":142,"faqs":143,"seo_title":144,"seo_description":67,"update_tm":145,"read_time":146,"preview_page_count":4},962090768658,"https://ap-avatar.wpscdn.com/davatar_6f874abed73319feea01a86fa6f0fab8","Allergy, Asthma & Clinical Immunology (2025) 21:55 [https://doi.org/10.1186/s13223-025-00992-1](https://doi.org/10.1186/s13223-025-00992-1)  \nAllergy, Asthma & Clinical Immunology  \nMEETING ABSTRACTS Open Access  \nAbstracts of the 14th C1-inhibitor Deficiency and Angioedema Workshop  \nBudapest, Hungary. 29 May–1 June 2025  \nPreface  \nWe are pleased to welcome all participants to the 14th C1-inhibitor Deficiency & Angioedema Workshop.  \nThe aim of the Workshop is to present new research findings related to rare bradykinin-mediated angioedema disorders. These include conditions caused by hereditary or acquired C1-inhibitor deficiency, as well as those with a hereditary background but normal C1-inhibitor levels. This year, a record number of abstracts will be presented over the fourday program, including 49 oral and 58 poster presentations. In addition to previously unpublished findings, five outstanding keynote lectures will also be delivered.  \nOn the opening afternoon, Nobel Laureate Katalin Karikó will give a special lecture on the development of the mRNA vaccine, sharing all the insights gained from the long and persistent journey that led to the production of life-saving mRNA-based vaccines.  \nThe upcoming days of the program are also filled with a wealth of engaging topics. Of theoretical significance is the presentation by Stephen Thiel on ITIH4 (Inter-α-trypsin inhibitor heavy chain 4), a regulator of plasma proteolytic systems. ITIH4 may play a regulatory role in the complement-kallikrein system, especially under conditions where C1-inhibitor is absent or dysfunctional.  \nMonoclonal antibody-based therapies are increasingly used to prevent symptoms in angioedema disorders. However, the nature of these antibodies, including how they are dispersed, processed, and degraded within the body, is rarely discussed among prescribing specialists. László Cervenak will provide a comprehensive overview on this topic.  \nAs Anastasios Germenis will highlight, the diagnosis of specific types of HAE with normal C1-inhibitor (HAE-nC1-INH) can only be confirmed by identifying a known pathogenic variant in one of the genes associated with the disease. His presentation will offer guidance on how to interpret and apply genetic results.  \nBruce Zuraw will summarize key clinical considerations that practicing physicians must keep in mind when prescribing preventive therapies developed through clinical trials.  \nThe Workshop also serves as an ideal platform to develop international consensus documents or guidelines based on thoroughly prepared collaborative work. This year, we will engage participants in developing professional recommendations for the modern management of hereditary angioedema in children.  \nThe 14th C1-inhibitor Deficiency & Angioedema Workshop is also avenue for celebration. It is a tradition to honor a distinguished professional with the‘For HAE Patients’ Award, recognizing outstanding contributions to improving the lives of patients.  \nThis year’s honoree is Laurence Bouillet, Clinical Director of the Internal Medicine/Clinical Immunology Unit at the University of Grenoble  \nand Vice President of the French National Society of Internal Medicine. Throughout her career, she has gained international recognition not only for her research but also for leading France’s National Reference Center for Angioedema (CREAK) .  \nA posthumous ‘For HAE Patients’ Award is presented in memory of Marcus Maurer, who passed away unexpectedly in 2024. He was Professor of Dermatology and Allergy, and Executive Director of the Institute of Allergology at Charité – Universitätsmedizin Berlin. His pioneering work, though cut short, created a lasting legacy, and his colleagues and students continue his initiatives.  \nOn the final day of the Workshop, we will recognize outstanding young researchers. An independent jury chaired by Stephen Betschel will award the ‘Grant for Young Investigator’ and the accompanying financial prize to the four best oral a","cbCaieoSS8gxN9k7","https://ap.wps.com/l/cbCaieoSS8gxN9k7","pdf",2999420,37,"English","# Preface\n## Workshop aims and research focus\n## Program highlights and key topics\n## Awards, young investigator grant, and publication plans","[{\"question\":\"What is the main purpose of the 14th C1-inhibitor Deficiency and Angioedema Workshop?\",\"answer\":\"To present new research findings related to rare bradykinin-mediated angioedema disorders, including hereditary and acquired C1-inhibitor deficiency and HAE with normal C1-inhibitor levels.\"},{\"question\":\"How are HAE with normal C1-inhibitor levels diagnosed according to the preface?\",\"answer\":\"Diagnosis is confirmed by identifying a known pathogenic variant in one of the genes associated with the disease, and genetic results must be interpreted and applied accordingly.\"},{\"question\":\"What are the key themes covered by invited lectures?\",\"answer\":\"Topics include mRNA vaccine development, ITIH4 and its potential regulation of plasma proteolytic systems, monoclonal antibody therapies, and clinical considerations for preventive therapies from trials.\"}]","Abstracts of the 14th C1-inhibitor Deficiency and Angioedema Workshop - Part 14 - Opening and keynote highlights | PDF",1790626964,93]