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Women treated at MacKay Memorial Hospital between January 2019 and December 2022 were included, and immunohistochemistry was used to detect abnormal p53. Among 115 patients, 26 showed pathologically confirmed abnormal p53. Recurrence, mortality, and progression-free survival were significantly worse in the p53 abnormal group, with an overall survival trend toward poorer outcomes. Results support abnormal p53 as an indicator of poor prognosis and suggest consideration of more intensive adjuvant therapy.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":40,"@type":76,"position":81},"https://docshare.wps.com/document/research-report/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/abnormal-p53-expression-is-associated-with-poor-outcomes-in-grade-i-or-ii-stage-i-endometrioid-carcinoma-a-retrospective-single-institute-study/329332/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/abnormal-p53-expression-is-associated-with-poor-outcomes-in-grade-i-or-ii-stage-i-endometrioid-carcinoma-a-retrospective-single-institute-study/329332.png","ImageObject",300,407,{"name":92,"@type":93},"Eden","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-23","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",11,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What patient population was analyzed in the study?","Question",{"text":113,"@type":114},"Women with stage I, grade 1 or 2 endometrial endometrioid carcinoma who received comprehensive staging and adjuvant therapy between January 2019 and December 2022 were included.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"How was p53 abnormality determined?",{"text":118,"@type":114},"Pathologists interpreted immunohistochemistry staining of cancerous tissues to detect p53 abnormality.",{"name":120,"@type":111,"acceptedAnswer":121},"What outcomes differed between p53 abnormal and p53 normal groups?",{"text":122,"@type":114},"The p53 abnormal group showed significantly higher rates of recurrent disease status and mortality, along with worse progression-free survival; overall survival also showed a poorer trend.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},329332,1790159978,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":39,"category_name":40,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":44,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145,"preview_page_count":4},1374391974468,"https://ap-avatar.wpscdn.com/davatar_29158cc5080c5b710cf443261637dec0","J Gynecol Oncol. 2024 Nov;35(6):e78 [https://doi.org/10.3802/jgo.2024.35.e78](https://doi.org/10.3802/jgo.2024.35.e78)[ ](https://doi.org/10.3802/jgo.2024.35.e78)pISSN 2005-0380·eISSN 2005-0399  \nOriginal Article  \nReceived: Nov 6, 2023  \nRevised: Feb 4, 2024  \nAccepted: Feb 25, 2024  \nPublished online: Mar 22, 2024  \nCorrespondence to  \nJen-Ruei Chen  \nDepartment of Obstetrics & Gynecology, MacKay Memorial Hospital, No. 92, Sec. 2, Chung-Sang North Rd, Chung-Sang Dist. Taipei 10464, Taiwan, Republic of China.  \nEmail: [justyray@mmh.org.tw](justyray@mmh.org.tw)[ ](justyray@mmh.org.tw)[cremaster4471@gmail.com](cremaster4471@gmail.com)  \n© 2024. Asian Society of Gynecologic Oncology, Korean Society of Gynecologic Oncology, and Japan Society of Gynecologic Oncology  \nThis is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License ([https://](https://)[ ](https://)[creativecommons.org/licenses/by-nc/4.0/](creativecommons.org/licenses/by-nc/4.0/)) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.  \nORCID iDs  \nYu-Wei Chang  [https://orcid.org/0009-0008-1587-1075](https://orcid.org/0009-0008-1587-1075)[ ](https://orcid.org/0009-0008-1587-1075)Hsiao-Li Kuo  [https://orcid.org/0009-0004-6336-807X](https://orcid.org/0009-0004-6336-807X)[ ](https://orcid.org/0009-0004-6336-807X)Tzu-Chien Chen  [https://orcid.org/0000-0001-6338-7079](https://orcid.org/0000-0001-6338-7079)[ ](https://orcid.org/0000-0001-6338-7079)Jessica Chen  [https://orcid.org/0009-0001-4999-2704](https://orcid.org/0009-0001-4999-2704)[ ](https://orcid.org/0009-0001-4999-2704)Ling Lim  [https://orcid.org/0000-0001-7555-6394](https://orcid.org/0000-0001-7555-6394)[ ](https://orcid.org/0000-0001-7555-6394)[Kung-LiahngWang](Kung-LiahngWang)  [https://orcid.org/0000-0002-9439-0622](https://orcid.org/0000-0002-9439-0622)[ ](https://orcid.org/0000-0002-9439-0622)Jen-Ruei Chen  [https://orcid.org/0000-0001-8475-8705](https://orcid.org/0000-0001-8475-8705)  \nAbnormal p53 expression is associated with poor outcomes in grade I or II, stage I, endometrioid carcinoma:  \na retrospective single-institute study  \nYu-Wei Chang ,1 Hsiao-Li Kuo ,2 Tzu-Chien Chen ,3 Jessica Chen ,4 Ling Lim ,4 Kung-Liahng Wang ,1,5 Jen-Ruei Chen  1,5,6  \n1Department of Obstetrics & Gynecology, MacKay Memorial Hospital, Taipei, Taiwan 2Department of Nursing, MacKay Memorial Hospital, Taipei, Taiwan  \n3Department of Obstetrics & Gynecology, MacKay Memorial Hospital, Hsinchu Branch, Hsinchu, Taiwan 4Department of Obstetrics & Gynecology, MacKay Memorial Hospital, Tamsui Branch, New Taipei City, Taiwan  \n5Department of General Education, MacKay Junior College of Medicine, Nursing and Management, New Taipei City, Taiwan  \n6Department of Medicine, MacKay Medical College, New Taipei City, Taiwan  \nABSTRACT  \nObjective: The Cancer Genome Atlas study revealed an association between copy-number high (p53 abnormal) genetic mutation and poor prognosis in endometrial cancer in 2013. This retrospective study investigated outcomes in patients with abnormal p53 expression and stage I, low-grade endometrial endometrioid carcinoma (EEC) .  \nMethods: We enrolled women with stage I, grade 1 or 2 EEC who received comprehensive staging and adjuvant therapy between January 2019 and December 2022 at MacKay Memorial Hospital, Taipei, Taiwan. Pathologists interpreted immunohistochemistry stains of cancerous tissues to detect p53 mutation. We compared recurrence, survival, progressionfree survival, and overall survival between p53 abnormal and p53 normal groups.  \nResults: Of the 115 patients included, 26 had pathologically confirmed abnormal p53 expression. Of these 26 patients, five (19.2%) experienced recurrence, and two died due to disease progression. By contrast, no patients in the normal p53 group experienced disease recurrence or died due to disease progression. Significant intergrou","cbCaiplHLPeEBUGT","https://ap.wps.com/l/cbCaiplHLPeEBUGT","pdf",2112917,"English","# Abstract\n## Objective\n## Methods\n## Results\n## Conclusion\n# Synopsis and Introduction","[{\"question\":\"What patient population was analyzed in the study?\",\"answer\":\"Women with stage I, grade 1 or 2 endometrial endometrioid carcinoma who received comprehensive staging and adjuvant therapy between January 2019 and December 2022 were included.\"},{\"question\":\"How was p53 abnormality determined?\",\"answer\":\"Pathologists interpreted immunohistochemistry staining of cancerous tissues to detect p53 abnormality.\"},{\"question\":\"What outcomes differed between p53 abnormal and p53 normal groups?\",\"answer\":\"The p53 abnormal group showed significantly higher rates of recurrent disease status and mortality, along with worse progression-free survival; overall survival also showed a poorer trend.\"}]","Abnormal p53 expression is associated with poor outcomes in grade I or II, stage I, endometrioid carcinoma - a retrospective single-institute study | PDF",1789983701,23]