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It outlines introduction topics, including definitions, scope, history, and movement of toxicants, then expands to biochemical and molecular methods, analytical toxicant analysis, and quality assurance principles. 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All rights reserved.  \nPublished by John Wiley & Sons, Inc., Hoboken, New Jersey.  \nPublished simultaneously in Canada.  \nNo part of this publication may be reproduced, stored in a retrieval system, or transmitted in any form or by any means, electronic, mechanical, photocopying, recording, scanning, or otherwise, except as permitted under Section 107 or 108 of the 1976 United States Copyright Act, without either the prior written permission of the Publisher, or authorization through payment of the appropriate per-copy fee to the Copyright Clearance Center, Inc., 222 Rosewood Drive, Danvers, MA 01923, 978-750-8400, fax 978-646-8600, or on the web [at www.copyright.com. Requests](at www.copyright.com. Requests) to the Publisher for permission should be addressed to the Permissions Department, John Wiley & Sons, Inc., 111 River Street, Hoboken, NJ 07030,(201) 748-6011, fax (201) 748-6008 .  \nLimit of Liability/Disclaimer of Warranty: While the publisher and author have used their best efforts in preparing this book, they make no representations or warranties with respect to the accuracy or completeness of the contents of this book and specifically disclaim any implied warranties of merchantability or fitness for a particular purpose. No warranty may be created or extended by sales representatives or written sales materials. The advice and strategies contained herein may not be suitable for your situation. You should consult with a professional where appropriate. Neither the publisher nor author shall be liable for any loss of profit or any other commercial damages, including but not limited to special, incidental, consequential, or other damages.  \nFor general information on our other products and services please contact our Customer Care  \n[Department within the U.S. at](Department within the U.S. at) 877-762-2974, outside [the U.S. at 317-572-3993](the U.S. at 317-572-3993) or fax 317-572-4002.  \nWiley also publishes its books in a variety of electronic formats. Some content that appears in print, however, may not be available in electronic format.  \nLibrary of Congress Cataloging-in-Publication Data:  \nHodgson, Ernest, 1932–  \nA textbook of modern toxicology / Ernest Hodgson.—3rd ed.  \n[p. cm](p. cm).  \nIncludes bibliographical references and index.  \nISBN 0-471-26508-X  \n1. Toxicology. I. Title.  \nRA1211.H62 2004  \n615.9—dc22 2003017524  \nPrinted in the United States of America.  \n10 9 8 7 6 5 4 3 2 1  \n CONTENTS  \nPreface xix  \nContributors xxi  \nI Introduction 1  \n1 Introduction to Toxicology 3  \nErnest Hodgson  \n1.1 Definition and Scope, Relationship to Other Sciences, and History 3  \n1.1.1 Definition and Scope 3  \n1.1.2 Relationship to Other Sciences 8  \n1.1.3 A Brief History of Toxicology 8  \n1.2 Dose-Response Relationships 10  \n1.3 Sources of Toxic Compounds 10  \n1.3.1 Exposure Classes 11  \n1.3.2 Use Classes 11  \n1.4 Movement of Toxicants in the Environment 11  \nSuggested Reading 12  \n2 Introduction to Biochemical and Molecular Methods in Toxicology 13  \nErnest Hodgson, Gerald A. LeBlanc, Sharon A. Meyer, and Robert C. Smart  \n2.1 Introduction 13  \n2.2 Cell Culture Techniques 13  \n2.2.1 Suspension Cell Culture 14  \n2.2.2 Monolayer Cell Culture 14  \n2.2.3 Indicators of Toxicity in Cultured Cells 14  \n2.3 Molecular Techniques 16  \n2.3.1 Molecular Cloning 17  \n2.3.2 cDNA and Genomic Libraries 17  \n2.3.3 Northern and Southern Blot Analyses 18  \n2.3.4 Polymerase Chain Reaction (PCR) 18  \n2.3.5 Evaluation of Gene Expression, Regula","cbCaiqUnAoAqbYTg","https://ap.wps.com/l/cbCaiqUnAoAqbYTg","pdf",6634564,582,"English","# Contents\n## Preface\n## Contributors\n## I Introduction\n### 1 Introduction to Toxicology\n### 1.1 Definition and Scope, Relationship to Other Sciences, and History\n### 1.2 Dose-Response Relationships\n### 1.3 Sources of Toxic Compounds\n### 1.4 Movement of Toxicants in the Environment\n### 2 Introduction to Biochemical and Molecular Methods in Toxicology\n### 3 Toxicant Analysis and Quality Assurance Principles\n## II Classes of Toxicants\n### 4 Exposure Classes, Toxicants in Air, Water, Soil, Domestic and Occupational Settings\n### 5 Classes of Toxicants: Use Classes","[{\"question\":\"What topics are covered in the book’s Introduction section?\",\"answer\":\"The Introduction section covers toxicology definitions and scope, relationships to other sciences, a brief history, dose-response relationships, sources of toxic compounds, and the movement of toxicants in the environment.\"},{\"question\":\"How does the book approach biochemical and molecular methods in toxicology?\",\"answer\":\"It presents cell culture techniques and indicators of toxicity, followed by molecular techniques such as molecular cloning, cDNA/genomic libraries, Northern and Southern blot analyses, PCR, and evaluation of gene expression.\"},{\"question\":\"What does “quality assurance” include in toxicant analysis?\",\"answer\":\"The quality assurance portion outlines general policies for analytical laboratories, including SOPs, QA/QC manuals, procedural manuals, analytical methods files, LIMS, and specific QA and QC procedures.\"}]","A Textbook of Modern Toxicology - Third Edition - Preface to Contents | PDF",1789975584,1467]