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This study evaluates the real-world performance and safety of Plinest, a CE-marked class III injectable PN High Purification Technology (PN HPT) device (40 mg/2 mL). Sixty-six adult patients received intradermal PN HPT injections in up to three facial areas across three sessions. Clinician outcomes showed 100% visible facial improvement with 53.5% rated “marked” or “excellent,” while neck and décolleté results improved in over 93% and 88% of cases, respectively. No serious adverse events occurred.",{"@graph":69,"@context":123},[70,84,106],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/a-real-life-assessment-of-injectable-polynucleotides-high-purification-technology-in-aesthetic-medicine-for-skin-rejuvenation/420987/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/a-real-life-assessment-of-injectable-polynucleotides-high-purification-technology-in-aesthetic-medicine-for-skin-rejuvenation/420987.png","ImageObject",300,407,{"name":92,"@type":93},"Aria","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-30","2026-09-28",true,{"@type":102,"interactionType":103,"userInteractionCount":105},"InteractionCounter",{"@type":104},"ViewAction",13,{"@type":107,"mainEntity":108},"FAQPage",[109,115,119],{"name":110,"@type":111,"acceptedAnswer":112},"What is PN High Purification Technology (PN HPT) and how is it used in aesthetic medicine?","Question",{"text":113,"@type":114},"PN HPT refers to highly purified polynucleotides formulated for intradermal injection. It is designed to restore hydration, elasticity, and overall tissue quality, targeting visible signs of aging.","Answer",{"name":116,"@type":111,"acceptedAnswer":117},"How was Plinest evaluated in this real-life assessment?",{"text":118,"@type":114},"The study was observational and included 66 adult patients. Participants received intradermal PN HPT injections across three sessions, with treatment administered in up to three areas: face, neck, and décolleté.",{"name":120,"@type":111,"acceptedAnswer":121},"What were the key performance and safety findings?",{"text":122,"@type":114},"Clinicians reported visible improvement in 100% of facial treatments, with 53.5% rated as “marked” or “excellent.” Improvements were also seen in the neck and décolleté in over 93% and 88% of cases, and no serious adverse events occurred.","https://schema.org",{"og:url":83,"og:type":125,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":127,"canonical":83},"index,follow",{"doc_id":129,"site_id":62},420987,1790767543,{"code":4,"msg":5,"data":132},{"doc_id":129,"user_id":133,"nickname":92,"user_avatar":134,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":105,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":44,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":144,"read_time":145,"preview_page_count":4},2336464648322,"https://ap-avatar.wpscdn.com/avatar/2200025388227c56fec?_k=1778556882303663488","Journal of Cosmetic Dermatology  \nORIGINAL ARTICLE  OPEN ACCESS   \nA Real-Life Assessment of Injectable Polynucleotides High Purification Technology in Aesthetic Medicine for Skin Rejuvenation  \nLanza Eliana1  | Perna Anna2 | Bizzarri Stefania3 | Santoro Concetta4 | Cerutti Luisa5  | Dybala Agnieszka6 | Brunoro Andrea7  | Boffi Laura8 | Prussia Carolina9 | Saretta Simone10   \n1Estederm, Catania, Italy | 2Studio Perna, Napoli, Italy | 3Villa Alba, Rome, Italy | 4Ini villa alba centro storico, Rome, Italy | 5Università Sapienza Roma, Rome, Italy | 6Centro Medico Polispecialistico Analysis, Terracina, Italy | 7Beauty Formula Milano, Milan, Italy | 8Bovisio Polimedica Bovisio Masciago,  \nItaly | 9Medical Statistics Consultant, Locarno, Switzerland | 10Medicina Estetica Zazzaron, Treviso, Italy Correspondence: Lanza Eliana ([elylanza@hotmail.it](elylanza@hotmail.it))  \nReceived: 8 July 2025 | Revised: 15 October 2025 | Accepted: 24 October 2025  \nFunding: This study was not supported by any external funding. Mastelli Srl covered only the publication costs.  \nKeywords: PN HPT | polynucleotides | Polynucleotides High Purification Technology | skin quality | skin rejuvenation  \nABSTRACT  \nBackground: Polynucleotides (PN) are innovative polymers that improve skin hydration and elasticity, serving as alternatives to traditional dermal fillers. Medical devices based on PN High Purification Technology (PN HPT) represent a new generation of injectable products designed to restore hydration, elasticity, and overall tissue quality. PN HPT is known for its clinical versatility and excellent tolerability.  \nAims: To assess the real-world performance and safety of Plinest (40 mg/2 mL of PN HPT in a 2 mL pre-filled syringe), a CEmarked class III medical device for skin rejuvenation of the face, neck, and décolleté .  \nMethods: This observational clinical data collection involved 66 adult patients, each of whom could receive treatment in up to three areas (face, neck, décolleté) . Patients underwent three sessions of intradermal PN HPT injections. A total of 106 questionnaires were collected: 47 for the face, 33 for the neck, and 26 for the décolleté . Performance was evaluated using the Global Clinical Improvement Scale (GCI-S) and Global Aesthetic Improvement Scale (GAIS). Safety was monitored through spontaneous adverse event (AE) reporting.  \nResults: Clinician-reported outcomes showed visible improvement in 100% of facial treatments, with 53.5% rated as “marked” or“excellent.” In the neck and décolleté areas, moderate to significant improvements were observed in over 93% and 88% of cases, respectively. Patient satisfaction ranged from 97% to 100% . No serious AEs occurred.  \nConclusions: PN HPT demonstrated a favorable tolerability and performance profile in real-life aesthetic practice, supporting its role in improving skin quality and reducing signs of aging.  \n1 | Introduction  \nSkin aging is a multifactorial biological process influenced by intrinsic factors, such as chronological aging and genetic predisposition, as well as extrinsic factors, including environmental  \npollution and lifestyle habits [1] . The visible effects of this process—namely, loss of elasticity, increased skin roughness, thinning of the dermis, and the appearance of fine lines—are particularly evident in exposed areas like the face, neck, and décolleté . These regions are not only more vulnerable to  \nThis is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.  \n© 2026 The Author(s). Journal of Cosmetic Dermatology published by Wiley Periodicals LLC.  \nJournal of Cosmetic Dermatology, 2026; 25:e70532 1 of 9  \n[https://doi.org/10.1111/jocd.70532](https://doi.org/10.1111/jocd.70532)  \nphysiological aging and environmental damage but also play a crucial role in social perception, making them prime targets for aesthetic intervent","cbCaivnPPzzVD6EU","https://ap.wps.com/l/cbCaivnPPzzVD6EU","pdf",387450,"English","# Introduction\n# Background on Polynucleotides and PN HPT\n# Device and Indication (Plinest)\n# Study Design and Methods\n## Patient population and treatment areas\n## Outcome measures and safety monitoring\n# Results\n## Clinician-rated improvement\n## Patient satisfaction and safety\n# Conclusions","[{\"question\":\"What is PN High Purification Technology (PN HPT) and how is it used in aesthetic medicine?\",\"answer\":\"PN HPT refers to highly purified polynucleotides formulated for intradermal injection. It is designed to restore hydration, elasticity, and overall tissue quality, targeting visible signs of aging.\"},{\"question\":\"How was Plinest evaluated in this real-life assessment?\",\"answer\":\"The study was observational and included 66 adult patients. Participants received intradermal PN HPT injections across three sessions, with treatment administered in up to three areas: face, neck, and décolleté.\"},{\"question\":\"What were the key performance and safety findings?\",\"answer\":\"Clinicians reported visible improvement in 100% of facial treatments, with 53.5% rated as “marked” or “excellent.” Improvements were also seen in the neck and décolleté in over 93% and 88% of cases, and no serious adverse events occurred.\"}]","A Real-Life Assessment of Injectable Polynucleotides High Purification Technology in Aesthetic Medicine for Skin Rejuvenation | PDF",1790623346,23]