[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-337579-105":3,"detail-sidebar-cat-0-en-105":77,"doc-detail-337579-en":127},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":70,"head_meta":72,"extra_data":74,"updated_unix":76},105,"en","a-rare-coexistence-cutaneous-lobular-carcinoma-with-pyoderma-gangrenosum","A Rare Coexistence - Cutaneous Lobular Carcinoma with Pyoderma Gangrenosum","","A rare case report describes an 84-year-old woman with recurrent cutaneous metastatic lobular carcinoma alongside pyoderma gangrenosum. After initial breast cancer diagnosis and mastectomy with remission, she developed bilateral lower-extremity ulcerations that worsened after wound debridement, later confirmed by biopsies as lobular carcinoma metastasis with PG pathology. The narrative highlights an unusual clinical course, emphasizing pathergy and the need for high suspicion when PG worsens with minimal trauma or coexisting malignancy.",{"@graph":14,"@context":69},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/a-rare-coexistence-cutaneous-lobular-carcinoma-with-pyoderma-gangrenosum/337579/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/a-rare-coexistence-cutaneous-lobular-carcinoma-with-pyoderma-gangrenosum/337579.png","ImageObject",300,407,{"name":42,"@type":43},"Lucas Martin","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-28","2026-09-21",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",12,{"@type":57,"mainEntity":58},"FAQPage",[59,65],{"name":60,"@type":61,"acceptedAnswer":62},"Why is pathergy important in interpreting this patient’s symptoms?","Question",{"text":63,"@type":64},"The case describes worsening of pyoderma gangrenosum with debridement, consistent with pathergy, an exaggerated immune response by the skin to minimal trauma, which should raise clinical suspicion.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"What key conclusion does the report draw about the relationship between PG and malignancy?",{"text":68,"@type":64},"The report concludes that PG may present uniquely and worsen in conjunction with metastatic malignancy, showing a concurrent cutaneous manifestation of lobular carcinoma and PG.","https://schema.org",{"og:url":32,"og:type":71,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":73,"canonical":32},"index,follow",{"doc_id":75,"site_id":7},337579,1790111439,{"code":4,"msg":78,"data":79},"success",[80,84,88,92,97,102,106,111,116,119,123],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":81,"show_sort_weight":82,"slug":83},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Exam",70,"exam",{"id":93,"doc_module":4,"doc_module_name":25,"category_name":94,"show_sort_weight":95,"slug":96},5,"Comic",60,"comic",{"id":98,"doc_module":4,"doc_module_name":25,"category_name":99,"show_sort_weight":100,"slug":101},6,"Technology",50,"technology",{"id":103,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":104,"slug":105},7,40,"healthcare",{"id":107,"doc_module":4,"doc_module_name":25,"category_name":108,"show_sort_weight":109,"slug":110},8,"Research & Report",30,"research-report",{"id":112,"doc_module":4,"doc_module_name":25,"category_name":113,"show_sort_weight":114,"slug":115},9,"Religion & Spirituality",20,"religion-spirituality",{"id":114,"doc_module":4,"doc_module_name":25,"category_name":117,"show_sort_weight":114,"slug":118},"World Cup","world-cup",{"id":120,"doc_module":4,"doc_module_name":25,"category_name":121,"show_sort_weight":120,"slug":122},10,"Lifestyle","lifestyle",{"id":124,"doc_module":4,"doc_module_name":25,"category_name":125,"show_sort_weight":93,"slug":126},19,"General","general",{"code":4,"msg":78,"data":128},{"doc_id":75,"user_id":129,"nickname":42,"user_avatar":130,"doc_module":4,"category_id":103,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":131,"file_id":132,"file_url":133,"file_type":134,"file_size":135,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":93,"language":136,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":137,"faqs":138,"seo_title":139,"seo_description":12,"update_tm":140,"read_time":141},8796095360427,"https://ap-avatar.wpscdn.com/davatar_994ba38a5ba835b3df7d355c54d3ed8d","e-ISSN 1941-5923  \n© Am J Case Rep, 2024; 25: e942488 DOI: 10. 12659/AJCR.942488  \nReceived: 2023.09.09  \nAccepted: 2024.01.09  \nAvailable online: 2024.01.24  \nPublished: 2024.03.12  \nAuthors’ Contribution: Study Design A  \nData Collection B Statistical Analysis C Data Interpretation D Manuscript Preparation E Literature Search F Funds Collection G  \nABCDEF  \nABCDEF BD  \nABCDEF  \nCorresponding Author: Financial support: Conflict of interest:  \nA Rare Coexistence: Cutaneous Lobular Carcinoma with Pyoderma Gangrenosum  \n1 Sarah Sutton   \n1 Kathryn Haran  \n2 Amanda Mullins  \n3 Cindy Lamerson  \nCindy Lamerson, e-mail: [saxkw@sbcglobal.net](saxkw@sbcglobal.net)  \nNone declared  \nNone declared  \n1 School of Medicine, University of Nevada, Reno, NV, USA  \n2 Department of Dermatopathology, Diagnostic Pathology Medial Group, Sacramento, CA, USA  \n3 Department of Dermatology, Nevada Center for Dermatology, Reno, NV, USA  \nPatient: Female, 84-year-old  \nFinal Diagnosis: Pyoderma gangrenosum  \nSymptoms: Erythematous • friable • bleeding ulcers with a well-defined border  \nClinical Procedure: —  \nSpecialty: Dermatology  \nObjective: Unusual clinical course  \nBackground: Pyoderma gangrenosum (PG) is a neutrophilic inflammatory disease associated with inflammatory and autoimmune conditions and malignancies. Previously identified links between PG and cancer have included hematological malignancies, solid-organ tumors such as gastric adenocarcinoma, and breast cancer. While specific histologic subtypes of breast cancer such as ductal carcinoma have been associated with PG of the extremities, the literature is limited on the association between PG and cutaneous metastatic lobular carcinoma.  \nCase Report: We describe the case of an 84-year-old woman with recurrent cutaneous metastatic lobular carcinoma of the left anterior chest with concurrent pyoderma gangrenosum on her bilateral lower extremities. The patient was initially diagnosed with lobular carcinoma of the breast and underwent a left breast mastectomy and was inremission. One year later, she developed 2 lower-extremity ulcerations, which at the time were attributed to an injury and underlying venous stasis. She was referred to a wound care clinic, where the lesions worsened with surgical debridement. Six years later, she presented to the dermatology clinic with a rash on her chest wall and worsening of the ulcerations on her ankles bilaterally. Biopsies revealed lobular carcinoma metastatic to the skin of her anterior chest wall and histopathology consistent with pyoderma gangrenosum on her ankles.  \nConclusions: This case demonstrates a unique presentation of worsening pyoderma gangrenosum due to metastatic malignancy in conjunction with a cutaneous manifestation of lobular carcinoma.  \nKeywords: Breast Carcinoma In Situ • Dermatology • Pyoderma Gangrenosum  \nFull-text PDF: [https://www.amjcaserep.com/abstract/index/idArt/942488](https://www.amjcaserep.com/abstract/index/idArt/942488)  \n1604  —  4  19  \nPublisher’s note: All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers. Any product that may be evaluated in this article, or claim that may be made by its manufacturer, is not guaranteed or endorsed by the publisher  \nThis work is licensed under Creative Common AttributionNonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)  \ne942488-1  \nIndexed in: [PMC] [PubMed] [Emerging Sources Citation Index (ESCI)][Web of Science by Clarivate]  \nSutton [S. et](S. et) al:  \nSimultaneous pyoderma gangrenosum with cutaneous metastatic lobular carcinoma © Am J Case Rep, 2024; 25: e942488  \nBackground  \nPyoderma gangrenosum (PG) is a rare ulcerative condition with a poorly understood pathogenesis. Up to 50% of reported cases of PG are associated with concurrent systemic conditions such as rheumatoid arthritis, ulcerative colitis, Crohn’s disease,","cbCairrKCH6BnHZL","https://ap.wps.com/l/cbCairrKCH6BnHZL","pdf",1161930,"English","# Background\n## Case Report\n# Conclusions","[{\"question\":\"Why is pathergy important in interpreting this patient’s symptoms?\",\"answer\":\"The case describes worsening of pyoderma gangrenosum with debridement, consistent with pathergy, an exaggerated immune response by the skin to minimal trauma, which should raise clinical suspicion.\"},{\"question\":\"What key conclusion does the report draw about the relationship between PG and malignancy?\",\"answer\":\"The report concludes that PG may present uniquely and worsen in conjunction with metastatic malignancy, showing a concurrent cutaneous manifestation of lobular carcinoma and PG.\"}]","A Rare Coexistence - Cutaneous Lobular Carcinoma with Pyoderma Gangrenosum | PDF",1790019672,13]