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This case report describes a 29-year-old male with recurrent constipation and anal discomfort, initially diagnosed with SRUS by colonoscopy and pathology. Persistent symptoms despite long-term mesalazine led to discovery of mucinous adenocarcinoma shortly thereafter. Surgical resection plus adjuvant FOLFOX chemotherapy controlled disease progression, with immunohistochemistry showing MLH1, MSH2, MSH6, PMS2, and HER2 positivity.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/a-rare-case-report-of-mucinous-adenocarcinoma-exacerbated-by-long-standing-solitary-rectal-ulcer-syndrome/328442/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/a-rare-case-report-of-mucinous-adenocarcinoma-exacerbated-by-long-standing-solitary-rectal-ulcer-syndrome/328442.png","ImageObject",300,407,{"name":92,"@type":93},"Liam","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-27","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":44},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is the main clinical problem described in this case report?","Question",{"text":112,"@type":113},"The report describes a rare rapid progression from solitary rectal ulcer syndrome (SRUS) to mucinous adenocarcinoma.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How was SRUS initially diagnosed and how did the condition evolve?",{"text":117,"@type":113},"SRUS was diagnosed based on colonoscopy findings and pathological examination. Despite long-term mesalazine therapy, symptoms persisted and later evaluation revealed mucinous adenocarcinoma development within a short period.",{"name":119,"@type":110,"acceptedAnswer":120},"What treatment was used after cancer was identified?",{"text":121,"@type":113},"The patient underwent surgical resection, followed by postoperative adjuvant FOLFOX chemotherapy, which effectively controlled cancer progression.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},328442,1790015128,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":44,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":34,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144},8796095461564,"https://ap-avatar.wpscdn.com/davatar_155a257f0dc6eb9ab79c44ca47cae57d","Case Report  \nA rare case report of mucinous adenocarcinoma exacerbated by long-standing solitary rectal ulcer syndrome  \nQirong Tan 1,2\\#, Jiaxin Zhou3\\#, Ke Zhao4, Shaoyan Lian4, Jieying Li4, Yuanyan Huang4, Chuhui Qiu4, Jiang He5, Chaoqun Liu4,6  \n1Department of Family Medicine, the University of Hong Kong-Shenzhen Hospital, Shenzhen, China; 2Geriatric Medicine, The Sixth Affiliated Hospital of Sun Yat-sen University, Guangzhou, China; 3International School, Jinan University, Guangzhou, China; 4Department of Nutrition, School of Medicine, Jinan University, Guangzhou, China; 5Department of Mathematics and Physics, School of Biomedical Engineering, Southern Medical University, Guangzhou, China; 6Disease Control and Prevention Institute of Jinan University, Jinan University, Guangzhou, China Contributions: (I) Conception and design: Q Tan, J Zhou; (II) Administrative support: K Zhao, S Lian, J Li; (III) Provision of study materials or patients: Q Tan, C Liu; (IV) Collection and assembly of data: Y Huang, C Qiu, J He; (V) Data analysis and interpretation: Q Tan, J Zhou; (VI)  \nManuscript writing: All authors; (VII) Final approval of manuscript: All authors.  \n\\#These authors contributed equally to this work.  \nCorrespondence to: Chaoqun Liu, PhD. Department of Nutrition, School of Medicine, Jinan University, Huangpu West Road No. 601, Guangzhou 510632, China; Disease Control and Prevention Institute of Jinan University, Jinan University, Guangzhou, China. Email: [chaoqunliu@jnu.edu.cn](chaoqunliu@jnu.edu.cn); Jiang He, PhD. Department of Mathematics and Physics, School of Biomedical Engineering, Southern Medical University, Shatai Road No. 1838, Guangzhou 510515, [China. Email: hejiang01@smu.edu.cn](China. Email: hejiang01@smu.edu.cn).  \nBackground: Solitary rectal ulcer syndrome (SRUS) is a rare chronic rectal lesion with potential for malignant transformation, although cases of rapid progression to mucinous adenocarcinoma are infrequent.  \nThis case report highlights such an instance in a 29-year-old male patient, emphasizing the importance of  \nvigilance among clinicians for detecting canceration in SRUS patients.  \nCase Description: The patient presented with recurrent constipation and anal discomfort, initially diagnosed with SRUS based on colonoscopy and pathological examination. Despite long-term mesalazine treatment, symptoms persisted, and subsequent evaluation revealed the development of mucinousadenocarcinoma within a short period. Surgical resection, combined with adjuvant FOLFOX chemotherapy, effectively controlled cancer progression. Immunohistochemical analysis showed positive expression of MLH1(+), MSH2(+), MSH6(+), PMS2(+), and HER2(+), providing molecular insights into SRUS-associated  \nmucinous adenocarcinoma.  \nConclusions: This case underscores the need for increased awareness among clinicians regarding the potential for cancerous transformation in SRUS patients. Early detection and intervention are crucial for improving outcomes in SRUS-associated malignancies. Furthermore, this case adds to existing literature by presenting a rare instance of SRUS progressing rapidly to mucinous adenocarcinoma, highlighting the significance of regular monitoring and timely intervention in such cases. Further research is warranted to elucidate underlying mechanisms and risk factors, guiding future clinical practice and treatment strategies.  \nKeywords: Solitary rectal ulcer syndrome (SRUS); mucinous adenocarcinoma; colonoscopy; case report  \nReceived: 23 November 2023; Accepted: 31 March 2024; Published online: 24 May 2024.  \ndoi: 10.21037/acr-23-207  \nView this article at: [https://dx.doi.org/10.21037/acr-23-207](https://dx.doi.org/10.21037/acr-23-207)  \n© AME Case Reports. All rights reserved. AME Case Rep 2024;8:63 | [https://dx.doi.org/10.21037/acr-23-207](https://dx.doi.org/10.21037/acr-23-207)  \nPage 2 of 7 AME Case Reports, 2024  \nIntroduction  \nSolitary rectal ulcer syndrome (SRUS) is an unusual and long-lasting di","cbCairIHHytEHgUa","https://ap.wps.com/l/cbCairIHHytEHgUa","pdf",1257750,"English","# Case Report\n## Case Description\n## Conclusions\n# Introduction\n# Highlight box\n## Key findings\n## What is known and what is new?\n## What is the implication, and what should change now?","[{\"question\":\"What is the main clinical problem described in this case report?\",\"answer\":\"The report describes a rare rapid progression from solitary rectal ulcer syndrome (SRUS) to mucinous adenocarcinoma.\"},{\"question\":\"How was SRUS initially diagnosed and how did the condition evolve?\",\"answer\":\"SRUS was diagnosed based on colonoscopy findings and pathological examination. Despite long-term mesalazine therapy, symptoms persisted and later evaluation revealed mucinous adenocarcinoma development within a short period.\"},{\"question\":\"What treatment was used after cancer was identified?\",\"answer\":\"The patient underwent surgical resection, followed by postoperative adjuvant FOLFOX chemotherapy, which effectively controlled cancer progression.\"}]","A rare case report of mucinous adenocarcinoma exacerbated by long-standing solitary rectal ulcer syndrome | PDF",1789979799,18]