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Because such paired primary carcinomas are rare, clinicians should recognize the scenario to select an optimal treatment strategy.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/a-rare-case-of-synchronous-primary-gallbladder-and-sigmoid-colon-neoplasms/382128/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/a-rare-case-of-synchronous-primary-gallbladder-and-sigmoid-colon-neoplasms/382128.png","ImageObject",300,407,{"name":42,"@type":43},"MrHarris58","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-11-02","2026-09-24",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",15,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"How rare are synchronous primary gallbladder and sigmoid colon tumors?","Question",{"text":63,"@type":64},"Synchronous tumors in both the colon and the gallbladder are extremely infrequent, with only very few cases reported in the literature.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"What was the key finding in the surgical specimen?",{"text":68,"@type":64},"The surgical specimen showed sigmoid colon cancer with an incidental synchronous gallbladder cancer confirmed on histopathological examination.",{"name":70,"@type":61,"acceptedAnswer":71},"Why is clinician awareness important in this case?",{"text":72,"@type":64},"Because synchronous gallbladder and colonic carcinomas are rare, awareness helps physicians choose an optimal course of treatment rather than misclassifying the second tumor.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},382128,1790386629,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,110,115,120,123,127],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":107,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":108,"slug":109},7,40,"healthcare",{"id":111,"doc_module":4,"doc_module_name":25,"category_name":112,"show_sort_weight":113,"slug":114},8,"Research & Report",30,"research-report",{"id":116,"doc_module":4,"doc_module_name":25,"category_name":117,"show_sort_weight":118,"slug":119},9,"Religion & Spirituality",20,"religion-spirituality",{"id":118,"doc_module":4,"doc_module_name":25,"category_name":121,"show_sort_weight":118,"slug":122},"World Cup","world-cup",{"id":124,"doc_module":4,"doc_module_name":25,"category_name":125,"show_sort_weight":124,"slug":126},10,"Lifestyle","lifestyle",{"id":128,"doc_module":4,"doc_module_name":25,"category_name":129,"show_sort_weight":97,"slug":130},19,"General","general",{"code":4,"msg":82,"data":132},{"doc_id":79,"user_id":133,"nickname":42,"user_avatar":134,"doc_module":4,"category_id":107,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":97,"language":140,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":12,"update_tm":144,"read_time":145},687212988360,"https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c","Open Access Case  \nReport DOI: 10.7759/cureus.34445  \nReview began 01/17/2023  \nReview ended 01/25/2023  \nPublished 01/31/2023  \n© Copyright 2023  \nGalanis et al. This is an open access article distributed under the terms of the Creative Commons Attribution License CC-BY 4.0. , which permits unrestricted use , distribution , and reproduction in any medium , provided the original author and source are credited.  \nA Rare Case of Synchronous Primary Gallbladder and Sigmoid Colon Neoplasms  \nIlias Galanis 1 , Ioannis Lintzeris 1 , Magdalini Simou 1 , Georgios Stylianidis 1  \n1. 2nd Department of Surgery, Evangelismos General Hospital, Athens, GRC Corresponding author: Ilias Galanis, [iliasg100@gmail.com](iliasg100@gmail.com)  \nAbstract  \nColorectal cancer is considered the third most common cancer worldwide. On the other hand, gallbladder cancer is rare. Synchronous tumors in both the colon and the gallbladder are extremely infrequent. Herein, we report the case of a female patient with sigmoid colon cancer and incidental detection of synchronous gallbladder cancer on histopathological examination of the surgical specimen. As synchronous gallbladder and colonic carcinomas are rare, physicians should be aware of these so that an optimal course of treatment can be chosen.  \nCategories: Gastroenterology, General Surgery, Oncology  \nKeywords: biliary tract cancer, sigmoid cancer, synchronous cancers, gallbladder cancer, colonic cancer  \nIntroduction  \nColorectal cancer is the third most frequent type of cancer and accounts for approximately 1 out of 10 deaths caused by cancer. Gallbladder cancer is a rare type of malignancy, the fifth most common among the malignancies of the gastrointestinal tract [1] . Synchronous cancers, especially between the colon and the gallbladder, are extremely rare, with only very few cases reported in literature.  \nThe main risk factors for the development of multiple primary cancers are genetic, immunological, environmental and iatrogenic [2] . According to Horii et al., microsatellite instabilities, due to mutations in mismatch repair genes, play a major role in the development of synchronous cancers [3] . For this reason, patients suffering from Lynch syndrome and Peutz-Jeghers syndrome are at a higher risk of synchronous billiary tract and colonic cancers [4] . Patients who have previously undergone chemotherapy or radiotherapy are also at a high risk [2] . Despite the fact that they have long been recognized as a clinical entity, the treatment and prognosis of synchronous cancers remain controversial among physicians [1] . Here, we present the case of a 75-year-old female with synchronous primary sigmoid colon and gallbladder cancer.  \nCase Presentation  \nA 75-year-old female patient presented to our surgical department due to abdominal pain and hematochezia. Her past medical history included hypertension, diabetes mellitus, hypercholesterolemia and dementia. The patient was hemodynamically stable. Digital rectal examination revealed blood loss.  \nLaboratory tests indicated low hemoglobin (10 .5 mg/dl), which was the only positive laboratory finding. Colonoscopy revealed a large polypoid mass of the sigmoid colon (30 cm away from the anal verge), obstructing the lumen (Figure 1) . Multiple biopsies of this lesion were taken and showed a moderately differentiated adenocarcinoma. Computed tomography of the abdomen showed the lesion of the sigmoid colon and many enlarged lymph nodes alongside the left common iliac artery (Figures 2, 3) . It also revealed a gallbladder with signs of inflammation and a 2.2-cm gallstone (Figure 4) .  \nHow to cite this article  \nGalanis I, Lintzeris I, Simou M , et al. (January 31 , 2023) A Rare Case of Synchronous Primary Gallbladder and Sigmoid Colon Neoplasms. Cureus 15(1): e34445. DOI 10.7759/cureus.34445  \nFIGURE 1 : Sigmoid lesion almost obstructing the lumen  \nFIGURE 2: CT scan revealing distended colonic (sigmoid) loops  \nFIGURE 3: CT scan revealing distended loops a","cbCaihCzEiNDrr5j","https://ap.wps.com/l/cbCaihCzEiNDrr5j","pdf",1146884,"English","# Abstract\n# Introduction\n# Case Presentation\n# Discussion","[{\"question\":\"How rare are synchronous primary gallbladder and sigmoid colon tumors?\",\"answer\":\"Synchronous tumors in both the colon and the gallbladder are extremely infrequent, with only very few cases reported in the literature.\"},{\"question\":\"What was the key finding in the surgical specimen?\",\"answer\":\"The surgical specimen showed sigmoid colon cancer with an incidental synchronous gallbladder cancer confirmed on histopathological examination.\"},{\"question\":\"Why is clinician awareness important in this case?\",\"answer\":\"Because synchronous gallbladder and colonic carcinomas are rare, awareness helps physicians choose an optimal course of treatment rather than misclassifying the second tumor.\"}]","A Rare Case of Synchronous Primary Gallbladder and Sigmoid Colon Neoplasms | PDF",1790249207,13]