[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-339152-105":59,"doc-detail-339152-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","a-rare-case-of-synchronous-double-primary-hepatocellular-carcinoma-and-intrahepatic-cholangiocarcinoma-a-case-report","A rare case of synchronous double primary hepatocellular carcinoma and intrahepatic cholangiocarcinoma - A case report","","Synchronous hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC) are two primary liver cancers, and their simultaneous independent occurrence is rare. The report describes a 77-year-old woman with two suspected hepatic tumors, assessed by dynamic CT, EOB-MRI, and PET/CT, followed by surgical resection. Pathology confirmed ICC in one lesion and HCC in another, and postoperative adjuvant chemotherapy was given with no recurrence after one year.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/a-rare-case-of-synchronous-double-primary-hepatocellular-carcinoma-and-intrahepatic-cholangiocarcinoma-a-case-report/339152/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/a-rare-case-of-synchronous-double-primary-hepatocellular-carcinoma-and-intrahepatic-cholangiocarcinoma-a-case-report/339152.png","ImageObject",300,407,{"name":92,"@type":93},"Olivia Brown","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-29","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":44},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What makes this case unusual?","Question",{"text":112,"@type":113},"It documents synchronous double primary liver cancer, with independent HCC and ICC occurring at the same time, which is uncommon.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How were the two liver lesions evaluated preoperatively?",{"text":117,"@type":113},"Dynamic CT and ethoxybenzyl-magnetic resonance imaging identified two lesions, and PET/CT assessed their uptake characteristics.",{"name":119,"@type":110,"acceptedAnswer":120},"What was the outcome after treatment?",{"text":121,"@type":113},"Surgical resection confirmed the diagnoses, followed by adjuvant chemotherapy, and no recurrence was observed one year later.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},339152,1790089824,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":44,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":29,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144},16904993612988,"https://ap-avatar.wpscdn.com/davatar_a8503ba1806abce46bf441b54a3ca4cd","International Journal of Surgery Case Reports 118 (2024) 109599  \nContents lists available at ScienceDirect  \nInternational Journal of Surgery Case Reports  \njournal [homepage:](homepage: www.elsevier.com/locate/ijscr)[ www.elsevier.com/locate/ijscr](homepage: www.elsevier.com/locate/ijscr)  \nCase report  \nA rare case of synchronous double primary hepatocellular carcinoma and intrahepatic cholangiocarcinoma: A case report  \nTakahiro Fukuda a, Takashi Onoea, *, Naoki Tanimine a, Rie Yamamoto b, Kazuya Kuraokab, Hirotaka Tashiro a  \na Department of Surgery, National Hospital Organization, Kure Medical Center, 3-1 Aoyama-cho, Kure, Hiroshima 737-0023, Japan b Department of Pathology, National Hospital Organization, Kure Medical Center, 3-1 Aoyama-cho, Kure, Hiroshima 737-0023, Japan  \nA R T I C L E I N F O  \nKeywords:  \nHepatocellular carcinoma  \nIntrahepatic cholangiocarcinoma  \nDouble primary liver cancer  \nPositron emission tomography-computed tomography  \nPostoperative adjuvant chemotherapy  \nA B S T R A C T  \nIntroduction: Hepatocellular carcinoma (HCC) and intrahepatic cholangiocarcinoma (ICC) are two primary liver cancers. Synchronous occurrence of both types is rare. Here, we present a case of synchronous, double primary liver cancer in a patient who underwent successful surgical resection.  \nPresentation of a case: A 77-year-old woman presented with two suspected liver tumors. Dynamic computed tomography (CT) and ethoxybenzyl-magnetic resonance imaging revealed two lesions, one in hepatic segments S8/4 and another in S5. Positron emission tomography (PET)/CT scans revealed an elevated maximum standardized uptake value (SUVmax) of 5.7 in the S8/4 tumor, and no elevation in the S5 tumor. The S8/4 tumor was diagnosed as either ICC or mixed-type liver cancer, while the S5 tumor was confirmed HCC. Surgical resection confirmed the diagnosis, while pathology identified the S8/4 tumor as ICC and the S5 tumor as HCC. Two months post-operation, the patient received adjuvant chemotherapy and completed eight courses with no recurrence one year later.  \nDiscussion: Synchronous double-primary HCC and ICC is uncommon and exhibits diagnostic and therapeutic challenges. Notably, PET-CT scans can differentiate between the two cancers, with HCC typically showing similar uptake to the background liver tissue, whereas ICC is often found with higher accumulation. This highlights the potential utility of PET/CT in preoperative diagnoses and the potential benefit of postoperative adjuvant chemotherapy in patients with double primary HCC and ICC.  \nConclusion: We report a successful case of synchronous double primary liver cancer, emphasizing the potential role of PET/CT in preoperative differentiation, and the efficacy of postoperative adjuvant chemotherapy.  \n1. Introduction  \nHepatocellular carcinomas (HCC) and intrahepatic cholangiocarcinomas (ICC) are distinct primary liver cancers. Simultaneous presence in the same patient is defined as synchronous double primary liver cancer. While some reports have described cases of combined HCCICC within a single tumor, double primary HCC and ICC (dpHCC-ICC), where both cancers exist separately within the liver, are rare. Jung et al. estimated its prevalence as only 0.23 % of all primary liver cancers [1].  \nHere, we report a case of dpHCC-ICC in a patient who was successfully treated with liver resection. This case is reported in accordance with the Surgical Case Report (SCARE) 2023 criteria [2].  \n2. Presentation of case  \nA 77-year-old woman with chronic hepatitis B, not receiving nucleic acid analog therapy, was referred to our department after follow-up imaging revealed two liver tumors. Laboratory tests revealed normal  \nAbbreviations: 18F-FDG, 18F-fluorodeoxyglucose; CA19-9, carbohydrate antigen 19-9; CEA, carcinoembryonic antigen; CT, computed tomography; DCP, des-γ-carboxy prothrombin; dpHCC-ICC, double primary HCC and ICC; EOB-MRI, ethoxybenzyl-magnetic resonance imaging; HBV, hepatitis B vir","cbCain1STnZB2G9M","https://ap.wps.com/l/cbCain1STnZB2G9M","pdf",5713314,"English","# Introduction\n# Presentation of case\n# Discussion\n# Conclusion","[{\"question\":\"What makes this case unusual?\",\"answer\":\"It documents synchronous double primary liver cancer, with independent HCC and ICC occurring at the same time, which is uncommon.\"},{\"question\":\"How were the two liver lesions evaluated preoperatively?\",\"answer\":\"Dynamic CT and ethoxybenzyl-magnetic resonance imaging identified two lesions, and PET/CT assessed their uptake characteristics.\"},{\"question\":\"What was the outcome after treatment?\",\"answer\":\"Surgical resection confirmed the diagnoses, followed by adjuvant chemotherapy, and no recurrence was observed one year later.\"}]","A rare case of synchronous double primary hepatocellular carcinoma and intrahepatic cholangiocarcinoma - A case report | PDF",1790028248,15]