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This report describes a 73-year-old man with progressive fatigue, dyspnea, and weight loss over nine months, followed by leg blood clots. Imaging showed pleural and pericardial fluid collections, and pathology found malignant cells in pericardial fluid. Anticoagulant therapy and palliative care led to improvement after one month, highlighting thrombosis and effusions as potential tumor-related clues.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/a-rare-case-of-pancreatic-adenocarcinoma-accompanied-by-venous-thrombosis-pleural-and-pericardial-effusions/330378/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/a-rare-case-of-pancreatic-adenocarcinoma-accompanied-by-venous-thrombosis-pleural-and-pericardial-effusions/330378.png","ImageObject",300,407,{"name":92,"@type":93},"Olivia Brown","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-27","2026-09-21",true,{"@type":102,"interactionType":103,"userInteractionCount":39},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What symptoms were reported in the 73-year-old patient before the diagnosis was suspected?","Question",{"text":112,"@type":113},"He had fatigue, shortness of breath, and weight loss over nine months, with recent blood clots in his legs.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How were pleural and pericardial effusions evaluated in this case?",{"text":117,"@type":113},"Chest imaging showed pleural and pericardial fluid, both were drained, and pathology revealed malignant cells in the pericardial fluid while pleural fluid was negative.",{"name":119,"@type":110,"acceptedAnswer":120},"What was the treatment approach and what outcome was reported after one month?",{"text":121,"@type":113},"The patient received anticoagulant treatment and palliative care, resulting in improvement after one month.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},330378,1790095174,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":39,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":19,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":52},16904993612988,"https://ap-avatar.wpscdn.com/davatar_a8503ba1806abce46bf441b54a3ca4cd","’Case Report  \nA rare case of pancreatic adenocarcinoma accompanied by venous thrombosis, pleural and pericardial effusions  \nHusam Shawakh, MSa,* , Hassan Bdeiwi, MSa , Rashed Aljundi, MSa , Fateh Kashkash, MDb , Abdullah Khoury, MDb  \nIntroduction: Pancreatic cancer is a deadly type of cancer with few symptoms until metastasis. It poses a high risk of cancerassociated thrombosis.  \nCase presentation: A 73-year-old male presented with fatigue, shortness of breath, weight loss since 9 months, and blood clots recently in his legs. Chest radiography revealed fluid accumulation in pleural and pericardial cavities. Later, a fluid examination revealed the presence of malignant cells in the pericardial fluid. After immunological tests and an upper gastrointestinal endoscopy were performed, a pancreatic tumour was suspected. The patient was administered anticoagulant treatment and palliative care, which resulted in improvement after one month.  \nDiscussion: Pancreatic adenocarcinoma is a highly aggressive cancer with a strong tendency to metastasize, leading to pericardialand pleural effusion, thrombophlebitis, and poor prognosis.  \nConclusion: This case indicates that venous thrombosis, pleural and pericardial effusions could be symptoms related to a pancreatic tumour.  \nKeywords: case report, pancreatic adenocarcinoma, pericardial effusions, pleural effusions, venous thrombosis  \nIntroduction  \nPancreatic cancer, which accounts for only 2% of all cancers, isone of the deadliest types of cancers, causing 5% of cancerrelated deaths. During the development and progression of pancreatic cancer, most patients do not experience any symptoms until they develop metastasis. The most common type of pancreatic cancer is pancreatic ductal adenocarcinoma (PDAC)[1] .  \nThe symptoms of PDAC can vary and include weight loss, abdominal pain, jaundice, and anorexia. Patients with pancreatic cancer may experience gastrointestinal bleeding as a complication[2] .  \nMalignancy of the pancreas is a well-known cause of clinically significant vascular thrombosis. This can lead to a 7–28 times higher risk of venous thromboembolism across all types of cancers. Pancreatic cancer is one of the malignancies that poses the highest risk of cancer-associated thrombosis (CAT) among all  \n[3]  \ncancers .  \naUniversity of Aleppo, Faculty of Medicine and bDepartment of Pulmonology, Aleppo  \nUniversity Hospital, University of Aleppo, Faculty of Medicine, Aleppo, Syria Sponsorships or competing interests that maybe relevant to content are disclosed atthe end of this article.  \n*Corresponding author. Address: Faculty of Medicine, University of Aleppo, Aleppo, Syria. Tel.: +963 991 [373 906. E-mail: hosam.n21@gmail.com](373 906. E-mail: hosam.n21@gmail.com) (H. Shawakh).  \nCopyright © 2024 The Author(s). Published by Wolters Kluwer Health, Inc. This is an open access article distributed under the Creative Commons Attribution-ShareAlike License 4.0, which allows others to remix, tweak, and build upon the work, even for commercial purposes, as long as the author is credited and the new creations are licensed under the identical terms.  \nAnnals of Medicine & Surgery (2024) 86:2277–2280  \nReceived 18 December 2023; Accepted 17 February 2024  \nPublished online 28 February 2024  \n[http://dx.doi.org/10.1097/MS9.0000000000001870](http://dx.doi.org/10.1097/MS9.0000000000001870)  \nHIGHLIGHTS  \n• The trio of pericardial effusion, thrombophlebitis, and pleural effusion can be indicative of pancreatic cancer  \n• The fact that the pleural fluid is free of tumour cells does not rule out the spread of the tumour in other body fluids.  \n• Also the tumour is stage 4, It is possible to find malignant cells in the pericardial fluid only and not in the pleural fluid.  \nWe report here a rare case of pancreatic cancer accompanied by arterial and venous thrombosis, pericardial effusion, and pleural effusion. These findings are rare to present together and tobe representative of a pancreatic cancer.  \nCase","cbCaia1ZTcjw6Wg5","https://ap.wps.com/l/cbCaia1ZTcjw6Wg5","pdf",378910,"English","# Introduction\n# Case presentation\n# Discussion\n# Conclusion\n# Highlights","[{\"question\":\"What symptoms were reported in the 73-year-old patient before the diagnosis was suspected?\",\"answer\":\"He had fatigue, shortness of breath, and weight loss over nine months, with recent blood clots in his legs.\"},{\"question\":\"How were pleural and pericardial effusions evaluated in this case?\",\"answer\":\"Chest imaging showed pleural and pericardial fluid, both were drained, and pathology revealed malignant cells in the pericardial fluid while pleural fluid was negative.\"},{\"question\":\"What was the treatment approach and what outcome was reported after one month?\",\"answer\":\"The patient received anticoagulant treatment and palliative care, resulting in improvement after one month.\"}]","A rare case of pancreatic adenocarcinoma accompanied by venous thrombosis, pleural and pericardial effusions | PDF",1789988552]