[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-453410-105":3,"detail-sidebar-cat-0-en-105":81,"doc-detail-453410-en":130},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","a-rare-case-of-gastric-glomangioma-mimicking-a-gastrointestinal-stromal-tumor-gist","A Rare Case of Gastric Glomangioma Mimicking a Gastrointestinal Stromal Tumor (GIST)","","Glomus tumors are rare mesenchymal neoplasms usually found in peripheral soft tissues; gastric involvement is uncommon and can create diagnostic uncertainty. This case report describes a 61-year-old woman with epigastric pain, nausea, and bloating. Endoscopy and endoscopic ultrasonography identified a submucosal gastric lesion resembling a gastrointestinal stromal tumor, leading to surgical excision. Histopathology confirmed gastric glomus tumor, with complete removal and negative margins. The postoperative course was uneventful, highlighting the need to include glomus tumors in differential diagnosis when imaging overlaps with GIST.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/a-rare-case-of-gastric-glomangioma-mimicking-a-gastrointestinal-stromal-tumor-gist/453410/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/a-rare-case-of-gastric-glomangioma-mimicking-a-gastrointestinal-stromal-tumor-gist/453410.png","ImageObject",300,407,{"name":42,"@type":43},"Oliver","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-30","2026-09-30",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",10,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"Why was the gastric glomangioma mistaken for a GIST?","Question",{"text":63,"@type":64},"The submucosal gastric lesion appeared similar to a gastrointestinal stromal tumor on endoscopy and endoscopic ultrasonography, creating diagnostic overlap.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"What diagnostic approach confirmed the final diagnosis?",{"text":68,"@type":64},"Histopathological evaluation confirmed a gastric glomus tumor, and immunohistochemical features are described as supportive in glomus tumors (SMA positive, CD117 and DOG1 negative).",{"name":70,"@type":61,"acceptedAnswer":71},"What treatment was performed and what was the outcome?",{"text":72,"@type":64},"Surgical excision was performed with complete removal and negative margins. The postoperative course was uneventful, with no complications during follow-up.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},453410,1790768979,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,110,115,120,123,126],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":107,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":108,"slug":109},7,40,"healthcare",{"id":111,"doc_module":4,"doc_module_name":25,"category_name":112,"show_sort_weight":113,"slug":114},8,"Research & Report",30,"research-report",{"id":116,"doc_module":4,"doc_module_name":25,"category_name":117,"show_sort_weight":118,"slug":119},9,"Religion & Spirituality",20,"religion-spirituality",{"id":118,"doc_module":4,"doc_module_name":25,"category_name":121,"show_sort_weight":118,"slug":122},"World Cup","world-cup",{"id":55,"doc_module":4,"doc_module_name":25,"category_name":124,"show_sort_weight":55,"slug":125},"Lifestyle","lifestyle",{"id":127,"doc_module":4,"doc_module_name":25,"category_name":128,"show_sort_weight":97,"slug":129},19,"General","general",{"code":4,"msg":82,"data":131},{"doc_id":79,"user_id":132,"nickname":42,"user_avatar":133,"doc_module":4,"category_id":107,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":111,"language":139,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":12,"update_tm":143,"read_time":118,"preview_page_count":4},8796095461610,"https://ap-avatar.wpscdn.com/davatar_276721f389ce27ea32af1340a28f341c","Review began 10/25/2025  \nReview ended 12/02/2025  \nPublished 12/07/2025  \n© Copyright 2025  \nYugruk et al. This is an open access article distributed under the terms of the Creative Commons Attribution License CC-BY 4.0. , which permits unrestricted use , distribution , and reproduction in any medium , provided the original author and source are credited.  \nDOI: 10.7759/cureus.98666  \nOpen Access Case Report  \nA Rare Case of Gastric Glomangioma Mimicking a Gastrointestinal Stromal Tumor (GIST)  \nAhmet Yugruk 1 , Altan Aydın 1, Orhan Semerci 2  \n1. Department of General Surgery, Kanuni Training and Research Hospital-Trabzon Provincial Health Directorate, Republic of Turkey Ministry of Health, Trabzon, TUR 2. Department of Pathology, Kanuni Training and Research Hospital-Trabzon Provincial Health Directorate, Republic of Turkey Ministry of Health, Trabzon, TUR  \nCorresponding author: Ahmet Yugruk, [dr.ahmetyugruk33@gmail.com](dr.ahmetyugruk33@gmail.com)  \nAbstract  \nGlomus tumors are rare mesenchymal neoplasms originating from modified smooth muscle cells involved in thermoregulation. Although typically located in peripheral soft tissues, their presence in the stomach is uncommon and may lead to diagnostic difficulties. This report presents a rare case of gastric glomangioma that clinically and radiologically mimicked a gastrointestinal stromal tumor. A 61-year-old woman presented in July 2024 with a three-month history of epigastric pain, nausea, and abdominal bloating. Upper gastrointestinal endoscopy revealed a submucosal lesion at the incisura angularis resembling a stromal tumor. Endoscopic ultrasonography demonstrated a well-circumscribed, submucosal, iso-hypoechoic mass measuring 19.5×11 .3 mm. Due to persistent symptoms, surgical excision was performed, and the mass was completely removed with negative margins. Histopathological evaluation confirmed the diagnosis of a gastric glomus tumor. The postoperative course was uneventful, and no complications were observed during follow-up. This case emphasizes the importance of including glomus tumors in the differential diagnosis of subepithelial gastric lesions, particularly when imaging findings overlap with more common entities. Increased clinical awareness may improve preoperative diagnostic accuracy and support appropriate management strategies.  \nCategories: General Surgery, Radiology, Pathology  \nKeywords: diagnostic pitfalls, gastric benign neoplasm, gastric glomangioma, gastric glomus, gist, immunohistochemistry, mesenchymal tumor  \nIntroduction  \nGlomus tumors are rare mesenchymal neoplasms arising from glomus bodies, which are specialized arteriovenous anastomoses involved in thermoregulation [1] . Although they are typically found in peripheral soft tissues, including the subungual regions, their occurrence in visceral organs, particularly within the gastrointestinal tract, is extremely rare. To date, fewer than 200 cases of gastric glomus tumors have been reported in the literature, underscoring their exceptional rarity. They account for approximately 1% of all glomus tumors and are most commonly located in the antrum [2,3] . Clinically, these tumors may present with nonspecific symptoms, such as epigastric pain, dyspepsia, nausea, vomiting, and upper gastrointestinal bleeding. Due to their submucosal localization and overlapping imaging characteristics, these tumors are frequently misdiagnosed as the more common gastrointestinal stromal tumors (GISTs) [4] . Distinguishing between these entities is crucial, as their management and prognosis differ significantly. Immunohistochemical profiling plays a pivotal role in diagnosis, as glomus tumors typically show positivity for smooth muscle actin (SMA) and negativity for cluster of differentiation 117 (CD117) and discovered on GIST-1 (DOG1) [5] . Complete surgical resection with negative margins remains the mainstay of treatment and serves both diagnostic and curative purposes. This study contributes to the limited lit","cbCaig4lkUqY6xRG","https://ap.wps.com/l/cbCaig4lkUqY6xRG","pdf",5597498,"English","# Abstract\n# Introduction\n# Case Presentation\n## Laboratory Findings\n## Endoscopy and Imaging\n# How to Cite This Article","[{\"question\":\"Why was the gastric glomangioma mistaken for a GIST?\",\"answer\":\"The submucosal gastric lesion appeared similar to a gastrointestinal stromal tumor on endoscopy and endoscopic ultrasonography, creating diagnostic overlap.\"},{\"question\":\"What diagnostic approach confirmed the final diagnosis?\",\"answer\":\"Histopathological evaluation confirmed a gastric glomus tumor, and immunohistochemical features are described as supportive in glomus tumors (SMA positive, CD117 and DOG1 negative).\"},{\"question\":\"What treatment was performed and what was the outcome?\",\"answer\":\"Surgical excision was performed with complete removal and negative margins. The postoperative course was uneventful, with no complications during follow-up.\"}]","A Rare Case of Gastric Glomangioma Mimicking a Gastrointestinal Stromal Tumor (GIST) | PDF",1790738811]