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This case report describes a 65-year-old male who, after surgery for laryngeal cancer, received five cycles of cisplatin and radiotherapy. During follow-up PET-CT, a newly developed right breast mass showed increased fluoro-D-glucose uptake. Ultrasound identified a hypoechoic retroareolar lesion with irregular borders, and mammography showed no calcifications. Biopsy indicated that the neuroendocrine laryngeal cancer subtype was compatible with breast metastasis.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/a-rare-case-isolated-metastasis-of-laryngeal-cancer-to-the-breast-in-a-male-patient/417369/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/a-rare-case-isolated-metastasis-of-laryngeal-cancer-to-the-breast-in-a-male-patient/417369.png","ImageObject",300,407,{"name":92,"@type":93},"acoobca","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-10-30","2026-09-28",true,{"@type":102,"interactionType":103,"userInteractionCount":34},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"Why are breast metastases from laryngeal cancer considered rare?","Question",{"text":112,"@type":113},"Distant organ metastasis from laryngeal cancer is described as extremely rare, and metastasis specifically to the breast is exceptionally uncommon.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"What imaging findings supported the diagnosis in this patient?",{"text":117,"@type":113},"Follow-up PET-CT showed a newly developed right breast mass with increased FDG uptake, and ultrasound demonstrated a hypoechoic retroareolar lesion with irregular borders; mammography did not show calcifications.",{"name":119,"@type":110,"acceptedAnswer":120},"How was the breast lesion ultimately confirmed?",{"text":121,"@type":113},"Pathological evaluation after biopsy demonstrated that the neuroendocrine type of laryngeal cancer was compatible with breast metastasis.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},417369,1791092808,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":34,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":24,"language":139,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":140,"faqs":141,"seo_title":142,"seo_description":67,"update_tm":143,"read_time":144,"preview_page_count":4},3985747870733,"https://ap-avatar.wpscdn.com/davatar_a8503ba1806abce46bf441b54a3ca4cd","| Case Report |\n| --- |\n|  |\n\nA Rare Case: Isolated Metastasis of Laryngeal Cancer to the  \nBreast in a Male Patient  \nAydan Arslan1*, Yusuf Ağaçkaya1, Duygu Demirtaş1, Büsra Niğdelioğlu2, İlker Akin3, Ayşe Mavi4  \n1Department of Radiology, University of Health Sciences Ümraniye Training and Research Hospital, Istanbul, Turkey, 2Department of Medical Oncology, University of Health Sciences Ümraniye Training and Research Hospital, Istanbul, Turkey, 3Department of Pathology, University of Health Sciences Ümraniye Training and Research Hospital, Istanbul, Turkey, 4Department of Nuclear Medicine, University of Health Sciences Ümraniye Training and Research Hospital, Istanbul, Turkey  \nAbstract  \nLaryngeal cancer is one of the common cancer types, and distant organ metastasis is extremely rare. We present a 65‑year‑old male patient who received five cycles of cisplatin and radiotherapy after surgery for laryngeal cancer. In the positron emission tomography‑computed tomography examination performed during the follow‑up, we observed a newly developed mass with increased fluoro‑D‑glucose uptake in the right breast. A hypoechoic lesion with irregular borders of approximately 17 mm × 11 mm × 17 mm was observed in the retroareolar region of the right breast in ultrasound. Calcification was not observed in mammography. In the pathological evaluation after biopsy, it was seen that the neuroendocrine type of laryngeal cancer was compatible with breast metastasis. Although rare, metastases to the breast should be kept in mind in cases with a primary tumor.  \nKeywords: Breast metastasis, laryngeal cancer, magnetic resonance imaging, male breast metastasis, positron emission tomography‑computed tomography  \nIntroductIon  \nNowadays, larynx cancer is one of the common cancer types and can be a source of morbidity and mortality. [1] In the last three decades, according to a study, the incidence and prevalence of the disease have increased from 12% to 24% .[1] According to the American Cancer Society, approximately 12,380 new laryngeal cancer cases were detected in the United States in 2023 (9900 in men and 2480 in women) . Laryngeal cancer is more common in males than females.[1,2] Most patients diagnosed with laryngeal cancer are 55 years or older, with an overall average age of 66.[1,2] The etiology of laryngeal cancer involves many factors, including smoking and alcohol consumption as the leading causes, along with anatomical malformations, gastroesophageal reflux, exposure to hot substances, certain viral infections, chemicals, and ionizing radiation.[1,2]  \nThe main symptom of laryngeal cancer is hoarseness. The most common type of laryngeal cancer is squamous cell carcinoma. [3] However, there may be other rare forms of  \nReceived: 21‑04‑2024 Revised: 09‑07‑2024 Accepted: 10‑07‑2024 Available Online: 18‑12‑2024  \n\n| Access this article online |  |\n| --- | --- |\n| Quick Response Code:\u003Cbr>| Website:\u003Cbr>[https://journals.lww.com/jmut](https://journals.lww.com/jmut) |\n|  | DOI:\u003Cbr>10.4103/jmu.jmu_45_24 |\n\nlaryngeal cancer, such as adenocarcinomas, sarcomas, lymphoma, and neuroendocrine tumors. [3] Neuroendocrine tumors ofthe larynx are quite rare, comprising approximately 1% of all types of laryngeal tumors.[4]  \nWhile distant organ metastasis of laryngeal cancer is not very common, according to the conducted study, distant organ metastasis was observed in approximately 19% of all cases.[5] The lung is the organ where laryngeal cancer most frequently metastasizes.[5]  \nMetastasis of laryngeal cancer in the breast is extremely rare. In fact, this case report represents the first case in English literature to our knowledge. In this case report, we present the case of a male patient with a neuroendocrine type of laryngeal cancer who developed isolated breast metastasis.  \nAddress for correspondence: Dr. Aydan Arslan,  \nDepartment of Radiology, University of Health Sciences İstanbul Ümraniye Training and Research Hospital, Selimiye, Tıbbiye Cd No: ","cbCaim3jot84Oy2Y","https://ap.wps.com/l/cbCaim3jot84Oy2Y","pdf",1472668,"English","# Abstract\n# Introduction\n## Epidemiology, risk factors, and clinical features\n# Case Report\n## Patient history and diagnostic workup","[{\"question\":\"Why are breast metastases from laryngeal cancer considered rare?\",\"answer\":\"Distant organ metastasis from laryngeal cancer is described as extremely rare, and metastasis specifically to the breast is exceptionally uncommon.\"},{\"question\":\"What imaging findings supported the diagnosis in this patient?\",\"answer\":\"Follow-up PET-CT showed a newly developed right breast mass with increased FDG uptake, and ultrasound demonstrated a hypoechoic retroareolar lesion with irregular borders; mammography did not show calcifications.\"},{\"question\":\"How was the breast lesion ultimately confirmed?\",\"answer\":\"Pathological evaluation after biopsy demonstrated that the neuroendocrine type of laryngeal cancer was compatible with breast metastasis.\"}]","A Rare Case - Isolated Metastasis of Laryngeal Cancer to the Breast in a Male Patient | PDF",1790608995,13]