[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"detail-sidebar-cat-0-en-105":3,"doc-seo-461791-105":59,"doc-detail-461791-en":130},{"code":4,"msg":5,"data":6},0,"success",[7,13,18,23,28,33,38,43,48,51,55],{"id":8,"doc_module":4,"doc_module_name":9,"category_name":10,"show_sort_weight":11,"slug":12},1,"Document","Story & Novel",90,"story-novel",{"id":14,"doc_module":4,"doc_module_name":9,"category_name":15,"show_sort_weight":16,"slug":17},2,"Literature",80,"literature",{"id":19,"doc_module":4,"doc_module_name":9,"category_name":20,"show_sort_weight":21,"slug":22},4,"Exam",70,"exam",{"id":24,"doc_module":4,"doc_module_name":9,"category_name":25,"show_sort_weight":26,"slug":27},5,"Comic",60,"comic",{"id":29,"doc_module":4,"doc_module_name":9,"category_name":30,"show_sort_weight":31,"slug":32},6,"Technology",50,"technology",{"id":34,"doc_module":4,"doc_module_name":9,"category_name":35,"show_sort_weight":36,"slug":37},7,"Healthcare",40,"healthcare",{"id":39,"doc_module":4,"doc_module_name":9,"category_name":40,"show_sort_weight":41,"slug":42},8,"Research & Report",30,"research-report",{"id":44,"doc_module":4,"doc_module_name":9,"category_name":45,"show_sort_weight":46,"slug":47},9,"Religion & Spirituality",20,"religion-spirituality",{"id":46,"doc_module":4,"doc_module_name":9,"category_name":49,"show_sort_weight":46,"slug":50},"World Cup","world-cup",{"id":52,"doc_module":4,"doc_module_name":9,"category_name":53,"show_sort_weight":52,"slug":54},10,"Lifestyle","lifestyle",{"id":56,"doc_module":4,"doc_module_name":9,"category_name":57,"show_sort_weight":24,"slug":58},19,"General","general",{"code":4,"msg":60,"data":61},"ok",{"site_id":62,"language":63,"slug":64,"title":65,"keywords":66,"description":67,"schema_data":68,"social_meta":123,"head_meta":125,"extra_data":127,"updated_unix":129},105,"en","a-presentation-of-fungating-nevoid-basal-cell-carcinoma-syndrome-open-access-case-report","A Presentation of Fungating Nevoid Basal Cell Carcinoma Syndrome - Open Access Case Report","","Gorlin syndrome, also known as nevoid basal cell carcinoma syndrome (NBCCS), is a rare autosomal dominant disorder characterized by multiple basal cell carcinomas (BCCs) developing at young ages. This open access case report presents a young adult Caucasian female with complex social and medical history, where social determinants influenced her management and treatment plan. A chronic nonhealing BCC progressed into an ulcerative fungating mass, leading to left arm amputation and BCC recurrence at the amputation site, treated with ED&C, Mohs surgery, and cemiplimab immunotherapy.",{"@graph":69,"@context":122},[70,84,105],{"@type":71,"itemListElement":72},"BreadcrumbList",[73,77,79,82],{"item":74,"name":75,"@type":76,"position":8},"https://docshare.wps.com","Home","ListItem",{"item":78,"name":9,"@type":76,"position":14},"https://docshare.wps.com/document/",{"item":80,"name":35,"@type":76,"position":81},"https://docshare.wps.com/document/healthcare/",3,{"item":83,"name":65,"@type":76,"position":19},"https://docshare.wps.com/document/a-presentation-of-fungating-nevoid-basal-cell-carcinoma-syndrome-open-access-case-report/461791/",{"url":83,"name":65,"@type":85,"image":86,"author":91,"headline":65,"publisher":94,"fileFormat":97,"inLanguage":63,"description":67,"dateModified":98,"datePublished":99,"encodingFormat":97,"isAccessibleForFree":100,"interactionStatistic":101},"DigitalDocument",{"url":87,"@type":88,"width":89,"height":90},"https://docshare.wps.com/thumbnails/a-presentation-of-fungating-nevoid-basal-cell-carcinoma-syndrome-open-access-case-report/461791.png","ImageObject",300,407,{"name":92,"@type":93},"Logic","Person",{"url":74,"name":95,"@type":96},"DocShare","Organization","application/pdf","2026-11-07","2026-09-30",true,{"@type":102,"interactionType":103,"userInteractionCount":14},"InteractionCounter",{"@type":104},"ViewAction",{"@type":106,"mainEntity":107},"FAQPage",[108,114,118],{"name":109,"@type":110,"acceptedAnswer":111},"What is Gorlin syndrome (NBCCS) and what genetic pathway is involved?","Question",{"text":112,"@type":113},"Gorlin syndrome, also known as nevoid basal cell carcinoma syndrome (NBCCS), is a rare autosomal dominant condition marked by numerous basal cell carcinomas. It arises from mutations that disrupt the Hedgehog signaling pathway, most frequently involving PTCH1, PTCH2, and SUFU.","Answer",{"name":115,"@type":110,"acceptedAnswer":116},"How is a diagnosis of NBCCS established in this report?",{"text":117,"@type":113},"A diagnosis can be established using one major criterion with molecular confirmation, two major criteria, or one major and two minor criteria. The report also summarizes major and minor diagnostic criteria and notes specific patient status for each.",{"name":119,"@type":110,"acceptedAnswer":120},"What treatments were used for the fungating BCC in the case patient?",{"text":121,"@type":113},"The patient’s lesions were targeted using a combination of electrodessication and curettage (ED&C), Mohs surgery, and cemiplimab immunotherapy.","https://schema.org",{"og:url":83,"og:type":124,"og:title":65,"og:site_name":95,"og:description":67},"article",{"robots":126,"canonical":83},"index,follow",{"doc_id":128,"site_id":62},461791,1790762422,{"code":4,"msg":5,"data":131},{"doc_id":128,"user_id":132,"nickname":92,"user_avatar":133,"doc_module":4,"category_id":34,"category_name":35,"doc_title":65,"doc_description":67,"doc_content":134,"file_id":135,"file_url":136,"file_type":137,"file_size":138,"view_count":14,"is_deleted":4,"is_public":8,"is_downloadable":8,"audit_status":8,"page_count":139,"language":140,"language_code":63,"site_id":62,"html_lang":63,"table_of_contents":141,"faqs":142,"seo_title":143,"seo_description":67,"update_tm":129,"read_time":144,"preview_page_count":4},1099513958762,"https://ap-avatar.wpscdn.com/avatar/1000023916a998db790?x-image-process=image/resize,m_fixed,w_180,h_180&k=1784791008015729253","Review began 09/29/2025  \nReview ended 10/30/2025  \nPublished 12/08/2025  \n© Copyright 2025  \nOgunremi et al. This is an open access article distributed under the terms of the Creative Commons Attribution License CCBY 4.0. , which permits unrestricted use , distribution , and reproduction in any medium , provided the original author and source are credited.  \nDOI: 10.7759/cureus.98759  \nOpen Access Case Report  \nA Presentation of Fungating Nevoid Basal Cell Carcinoma Syndrome  \nOluwafunke O. Ogunremi 1, Brant Hannahs 1, Kirstin Hockhausen 2  \n1. Department of Internal Medicine, University of South Dakota Sanford School of Medicine, Rapid City, USA 2. Department of Dermatology, University of South Dakota Sanford School of Medicine, Rapid City, USA  \nCorresponding author: Oluwafunke O. Ogunremi, [oluwafunke.ogunremi@coyotes.usd.edu](oluwafunke.ogunremi@coyotes.usd.edu)  \nAbstract  \nGorlin syndrome, also known as nevoid basal cell carcinoma syndrome (NBCCS), is a rare autosomal dominant disease marked by the development of numerous basal cell carcinomas (BCC) that tend to occur at young ages. Here the authors detail a case of a young adult Caucasian female with both a complex social and medical history. These social determinants of health played a significant role during her management and treatment plan. Although the patient had many eruptions of BCC throughout her body, one chronic, nonhealing BCC lesion located amidst a shoulder wound would eventually turn into an ulcerative fungating mass, resulting in amputation of the left arm with recurrence of the BCC at the site of amputation. The patient’s lesions were targeted with a combination of electrodessication and curettage (ED&C), Mohs surgery, and cemiplimab immunotherapy.  \nCategories: Palliative Care, Internal Medicine, Dermatology  \nKeywords: basal cell carcinoma variants, basal cell nevus syndrome, bcns, gorlin syndrome, nbccs, nevoid basal cell carcinoma syndrome  \nIntroduction  \nGorlin syndrome, also known as nevoid basal cell carcinoma syndrome (NBCCS), is a rare autosomal dominant disease marked by the development of numerous basal cell carcinomas (BCCs) that tends to occur between puberty and age 35 [1] . In the United States, the prevalence of Gorlin syndrome is one in 31,000, with an equal male-to-female ratio [2] . This condition arises from mutations that disrupt the Hedgehog signaling pathway, most frequently involving the patched 1 (PTCH1), patched 2 (PTCH2), and suppressor offused homolog (SUFU) genes [3] . These mutations result in constitutive activation of the pathway, promoting unchecked proliferation and tumor growth [4] .  \nWe report a case of Gorlin syndrome in a middle-aged adult female patient, whose diagnosis was established following extensive workup. This case highlights the importance of a multidisciplinary approach and a high index of suspicion when evaluating patients with compatible clinical features.  \nCase Presentation  \nA diagnosis of NBCCS can be established based on any of the following: (1) one major criterion with molecular confirmation; (2) two major criteria; or (3) one major and two minor criteria (Tables 1, 2) [5] .  \nHow to cite this article  \nOgunremi O O , Hannahs B , Hockhausen K (December 08 , 2025) A Presentation of Fungating Nevoid Basal Cell Carcinoma Syndrome. Cureus 17(12): e98759. DOI 10.7759/cureus.98759  \nMajor Criteria  \nOne basal cell carcinoma (BCC) under the age of 20 years  \nMultiple BCCs  \nOdontogenic keratocyst of the jaw proven by histology in an individual younger than 20 years  \nTwo or more palmar or plantar pits  \nLamellar (sheet-like) calcification of the falx cerebri or clear evidence of calcification in an individual younger than age of 20 years  \nChildhood medulloblastoma  \nFirst-degree relative with NBCCS  \nPresent or  \nAbsent  \nUnknown  \nPresent  \nAbsent  \nPresent*  \nAbsent  \nAbsent  \nAbsent  \nTABLE 1 : Major Diagnostic Criteria of NBCCS and Patient Status  \nMajor diagnostic criteria for NBCCS and diagnos","cbCaieACxxO0apCB","https://ap.wps.com/l/cbCaieACxxO0apCB","pdf",9521652,13,"English","# Abstract\n# Introduction\n# Case Presentation\n## Major Diagnostic Criteria\n## Minor Diagnostic Criteria\n# Evaluation, Diagnosis, and Treatment","[{\"question\":\"What is Gorlin syndrome (NBCCS) and what genetic pathway is involved?\",\"answer\":\"Gorlin syndrome, also known as nevoid basal cell carcinoma syndrome (NBCCS), is a rare autosomal dominant condition marked by numerous basal cell carcinomas. It arises from mutations that disrupt the Hedgehog signaling pathway, most frequently involving PTCH1, PTCH2, and SUFU.\"},{\"question\":\"How is a diagnosis of NBCCS established in this report?\",\"answer\":\"A diagnosis can be established using one major criterion with molecular confirmation, two major criteria, or one major and two minor criteria. The report also summarizes major and minor diagnostic criteria and notes specific patient status for each.\"},{\"question\":\"What treatments were used for the fungating BCC in the case patient?\",\"answer\":\"The patient’s lesions were targeted using a combination of electrodessication and curettage (ED\\u0026C), Mohs surgery, and cemiplimab immunotherapy.\"}]","A Presentation of Fungating Nevoid Basal Cell Carcinoma Syndrome - Open Access Case Report | PDF",33]