[{"data":1,"prerenderedAt":-1},["ShallowReactive",2],{"doc-seo-341265-105":3,"detail-sidebar-cat-0-en-105":81,"doc-detail-341265-en":131},{"code":4,"msg":5,"data":6},0,"ok",{"site_id":7,"language":8,"slug":9,"title":10,"keywords":11,"description":12,"schema_data":13,"social_meta":74,"head_meta":76,"extra_data":78,"updated_unix":80},105,"en","a-post-international-gastrointestinal-cancersconference-igicc-position-statements","A Post-International Gastrointestinal Cancers’Conference (IGICC) Position Statements","","Hepatocellular carcinoma (HCC) is the most prevalent primary liver tumor, strongly linked to chronic liver diseases such as cirrhosis. Global burden data place HCC among the leading cancers worldwide, with Asia accounting for most cases and a higher incidence in men. Key risks include viral infections, alcohol misuse, steatotic liver disease, and genetic predisposition, with many patients diagnosed at late stages. Advanced HCC management depends on disease stage and patient condition, and may involve curative liver resection, ablation, or transplantation, or non-curative systemic/arterial approaches, plus multidisciplinary care and combination immunotherapy strategies.",{"@graph":14,"@context":73},[15,34,56],{"@type":16,"itemListElement":17},"BreadcrumbList",[18,23,27,31],{"item":19,"name":20,"@type":21,"position":22},"https://docshare.wps.com","Home","ListItem",1,{"item":24,"name":25,"@type":21,"position":26},"https://docshare.wps.com/document/","Document",2,{"item":28,"name":29,"@type":21,"position":30},"https://docshare.wps.com/document/healthcare/","Healthcare",3,{"item":32,"name":10,"@type":21,"position":33},"https://docshare.wps.com/document/a-post-international-gastrointestinal-cancersconference-igicc-position-statements/341265/",4,{"url":32,"name":10,"@type":35,"image":36,"author":41,"headline":10,"publisher":44,"fileFormat":47,"inLanguage":8,"description":12,"dateModified":48,"datePublished":49,"encodingFormat":47,"isAccessibleForFree":50,"interactionStatistic":51},"DigitalDocument",{"url":37,"@type":38,"width":39,"height":40},"https://docshare.wps.com/thumbnails/a-post-international-gastrointestinal-cancersconference-igicc-position-statements/341265.png","ImageObject",300,407,{"name":42,"@type":43},"Violet","Person",{"url":19,"name":45,"@type":46},"DocShare","Organization","application/pdf","2026-10-31","2026-09-22",true,{"@type":52,"interactionType":53,"userInteractionCount":55},"InteractionCounter",{"@type":54},"ViewAction",13,{"@type":57,"mainEntity":58},"FAQPage",[59,65,69],{"name":60,"@type":61,"acceptedAnswer":62},"What are the main associations and risk factors for hepatocellular carcinoma (HCC)?","Question",{"text":63,"@type":64},"HCC is often associated with chronic liver diseases, particularly cirrhosis, and is linked to chronic viral infections, excessive alcohol intake, steatotic liver disease, and genetic/family predispositions.","Answer",{"name":66,"@type":61,"acceptedAnswer":67},"How is treatment selection for advanced HCC determined?",{"text":68,"@type":64},"Treatment selection depends on disease stage and the patient’s medical status, including pre-existing liver conditions, etiology, portal hypertension, and portal vein thrombosis.",{"name":70,"@type":61,"acceptedAnswer":71},"What treatment options may be considered for different HCC scenarios?",{"text":72,"@type":64},"Potentially curative approaches include liver resection, ablation, or transplantation. For inoperable lesions, arterially directed therapy or systemic treatment may be used, and external beam radiation therapy can be considered in specific cases.","https://schema.org",{"og:url":32,"og:type":75,"og:title":10,"og:site_name":45,"og:description":12},"article",{"robots":77,"canonical":32},"index,follow",{"doc_id":79,"site_id":7},341265,1790548433,{"code":4,"msg":82,"data":83},"success",[84,88,92,96,101,106,110,115,120,123,127],{"id":22,"doc_module":4,"doc_module_name":25,"category_name":85,"show_sort_weight":86,"slug":87},"Story & Novel",90,"story-novel",{"id":26,"doc_module":4,"doc_module_name":25,"category_name":89,"show_sort_weight":90,"slug":91},"Literature",80,"literature",{"id":33,"doc_module":4,"doc_module_name":25,"category_name":93,"show_sort_weight":94,"slug":95},"Exam",70,"exam",{"id":97,"doc_module":4,"doc_module_name":25,"category_name":98,"show_sort_weight":99,"slug":100},5,"Comic",60,"comic",{"id":102,"doc_module":4,"doc_module_name":25,"category_name":103,"show_sort_weight":104,"slug":105},6,"Technology",50,"technology",{"id":107,"doc_module":4,"doc_module_name":25,"category_name":29,"show_sort_weight":108,"slug":109},7,40,"healthcare",{"id":111,"doc_module":4,"doc_module_name":25,"category_name":112,"show_sort_weight":113,"slug":114},8,"Research & Report",30,"research-report",{"id":116,"doc_module":4,"doc_module_name":25,"category_name":117,"show_sort_weight":118,"slug":119},9,"Religion & Spirituality",20,"religion-spirituality",{"id":118,"doc_module":4,"doc_module_name":25,"category_name":121,"show_sort_weight":118,"slug":122},"World Cup","world-cup",{"id":124,"doc_module":4,"doc_module_name":25,"category_name":125,"show_sort_weight":124,"slug":126},10,"Lifestyle","lifestyle",{"id":128,"doc_module":4,"doc_module_name":25,"category_name":129,"show_sort_weight":97,"slug":130},19,"General","general",{"code":4,"msg":82,"data":132},{"doc_id":79,"user_id":133,"nickname":42,"user_avatar":134,"doc_module":4,"category_id":107,"category_name":29,"doc_title":10,"doc_description":12,"doc_content":135,"file_id":136,"file_url":137,"file_type":138,"file_size":139,"view_count":55,"is_deleted":4,"is_public":22,"is_downloadable":22,"audit_status":22,"page_count":140,"language":141,"language_code":8,"site_id":7,"html_lang":8,"table_of_contents":142,"faqs":143,"seo_title":144,"seo_description":12,"update_tm":145,"read_time":146},4398048950312,"https://ap-avatar.wpscdn.com/avatar/400002538284de19e3c?_k=1778320343897328908","Journal of Hepatocellular Carcinoma Dovepress  \nopen access to scientific and medical research  \n Open Access Full Text Article EXPERT OPINION  \nA Post-International Gastrointestinal Cancers’Conference (IGICC) Position Statements  \nSuayib Yalcin 1 , Sahin Lacin 2 , Ahmed Omar Kaseb 3 , Bora Peynircioğlu4 , Murat Cantasdemir 5 , Barbaros Erhan Çil 6 , Pervin Hurmuz 7 , Ahmet Bülent Doğrul8 , Murat Fani Bozkurt9 , Hüseyin Abali 10 , Okan Akhan4 , Halis Şimşek 11 , Berksoy Sahin 12 , Faruk N Aykan 13 , İdris Yücel 14 , Gürkan Tellioğlu 15 , Fatih Selçukbiricik2 , Philip A Philip 16  \n1Department of Medical Oncology, Hacettepe University Faculty of Medicine, Ankara, Turkey; 2Department of Medical Oncology, Koç University Faculty of Medicine, İstanbul, Turkey; 3Department of Gastrointestinal Medical Oncology, University of Texas, MD Anderson Cancer Center, Houston, TX, USA; 4Department of Radiology, Hacettepe University Faculty of Medicine, Ankara, Turkey; 5Department of Radiology, Memorial Şişli Hospital,İstanbul, Turkey; 6Department of Radiology, Koç University Faculty of Medicine, İstanbul, Turkey; 7Department of Radiation Oncology, Hacettepe University Faculty of Medicine, Ankara, Turkey; 8Department of General Surgery, Hacettepe University Faculty of Medicine, Ankara, Turkey; 9Department of Nuclear Medicine, Hacettepe University Faculty of Medicine, Ankara, Turkey; 10Department of Medical Oncology, Bahrain Oncology Center, Muharraq, Bahrain; 11Department of Gastroenterology, Hacettepe University Faculty of Medicine, Ankara, Turkey; 12Department of Medical Oncology, Cukurova University Faculty of Medicine, Adana, Türkiye; 13Department of Medical Oncology, Istinye University Faculty of Medicine Bahçeşehir Liv Hospital, İstanbul, Turkey; 14Medicana International Hospital Samsun, Department of Medical Oncology, Samsun, Turkey; 15Department of General Surgery, Koç University Faculty of Medicine, İstanbul, Turkey; 16Department of Medicine, Division of Hematology-Oncology, Karmanos Cancer Institute, Wayne State University, Detroit, MI, USA  \nCorrespondence: Sahin Lacin, Email [sahin.lacin@hotmail.com](sahin.lacin@hotmail.com)  \n\n| Abstract: Hepatocellular carcinoma (HCC), the most prevalent liver tumor, is usually linked with chronic liver diseases, particularly cirrhosis. As per the 2020 statistics, this cancer ranks 6th in the list of most common cancers worldwide and is the third primary source of cancer-related deaths. Asia holds the record for the highest occurrence of HCC. HCC is found three times more frequently in men than in women. The primary risk factors for HCC include chronic viral infections, excessive alcohol intake, steatotic liver disease conditions, as well as genetic and family predispositions. Roughly 40–50% of patients are identified in the late stages of the disease. Recently, there have been significant advancements in the treatment methods for advanced HCC. The selection of treatment for HCC hinges on the stage of the disease and the patient’s medical status. Factors such as pre-existing liver conditions, etiology, portal hypertension, and portal vein thrombosis need critical evaluation, monitoring, and appropriate treatment. Depending on the patient and the characteristics of the disease, liver resection, ablation, or transplantation may be deemed potentially curative. For inoperable lesions, arterially directed therapy might be an option, or systemic treatment might be deemed more suitable. In specific cases, the recommendation might extend to external beam radiation therapy. For all individuals, a comprehensive, multidisciplinary approach should be adopted when considering HCC treatment options. The main treatment strategies for advanced HCC patients are typically combination treatments such as immunotherapy and anti-VEGFR inhibitor, or a combination of immunotherapy and immunotherapy where appropriate, as a first-line treatment. Furthermore, some TKIs and immune checkpoint inhibitors may be used as single ","cbCaive6TVPenTCf","https://ap.wps.com/l/cbCaive6TVPenTCf","pdf",681025,22,"English","# Introduction\n## Risk factors and epidemiology\n## Treatment strategies for advanced HCC","[{\"question\":\"What are the main associations and risk factors for hepatocellular carcinoma (HCC)?\",\"answer\":\"HCC is often associated with chronic liver diseases, particularly cirrhosis, and is linked to chronic viral infections, excessive alcohol intake, steatotic liver disease, and genetic/family predispositions.\"},{\"question\":\"How is treatment selection for advanced HCC determined?\",\"answer\":\"Treatment selection depends on disease stage and the patient’s medical status, including pre-existing liver conditions, etiology, portal hypertension, and portal vein thrombosis.\"},{\"question\":\"What treatment options may be considered for different HCC scenarios?\",\"answer\":\"Potentially curative approaches include liver resection, ablation, or transplantation. For inoperable lesions, arterially directed therapy or systemic treatment may be used, and external beam radiation therapy can be considered in specific cases.\"}]","A Post-International Gastrointestinal Cancers’Conference (IGICC) Position Statements | PDF",1790041205,55]